gene

RPN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

27Outgoing

16Incoming

0Experiments

0Debates

Summary

RPN1 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates, regulates. Associated with Cancer, Inflammation, Neuropathy. Connected to 18 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RPN1
Full Name	Ribophorin I
Chromosome	3q26.33
Protein Type	Transferase
Function	is a core component of the rough endoplasmic reticulum (ER).
Primary Expression	Ubiquitous, Rough ER, Pancreas
Pathways	Mitophagy
UniProt ID	P46976
NCBI Gene ID	6184
Ensembl ID	ENSG00000166788
OMIM	180478
GeneCards	RPN1
Human Protein Atlas	RPN1
Associated Diseases	ALS, dementia, frontotemporal, Neuropathy
Interactions	ATG14, BCL-2, CANCER, INFLAMMATION, LC3B, MAP1LC3B
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPN1 — AlphaFold P46976 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPN1 Gene

gene · 806 words

→

Pathway Diagram

graph TD
    RPN1["RPN1"]
    neurodegeneration{"neurodegeneration"}
    RPN1 -->|"implicated_in"| neurodegeneration
    AUTOPHAGY["AUTOPHAGY"]
    RPN1 -->|"implicated_in"| AUTOPHAGY
    PARKIN["PARKIN"]
    RPN1 -->|"regulates"| PARKIN
    Neuropathy{"Neuropathy"}
    RPN1 -->|"implicated_in"| Neuropathy
    Autophagy["Autophagy"]
    RPN1 -->|"implicated_in"| Autophagy
    Mitophagy["Mitophagy"]
    RPN1 -->|"regulates"| Mitophagy
    Differentiation["Differentiation"]
    RPN1 -->|"implicated_in"| Differentiation
    Unfolded_Protein_Response["Unfolded Protein Response"]
    RPN1 -->|"implicated_in"| Unfolded_Protein_Response
    Cancer{"Cancer"}
    RPN1 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    RPN1 -->|"activates"| Inflammation
    PINK1["PINK1"]
    PINK1 -->|"regulates"| RPN1
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| RPN1
    AMPK["AMPK"]
    AMPK -->|"implicated_in"| RPN1
    RPL26["RPL26"]
    RPL26 -->|"regulates"| RPN1
    RPN2["RPN2"]
    RPN2 -->|"activates"| RPN1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| RPN1
    CANCER["CANCER"]
    CANCER -->|"activates"| RPN1
    BCL_2["BCL-2"]
    BCL_2 -->|"activates"| RPN1
    style RPN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (27)

Target	Relation	Type	Str
OST-A	interacts_with	entity	0.80
cotranslational translocation	involved_in	process	0.80
Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Neuropathy	implicated_in	disease	0.65
PARKIN	regulates	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
Autophagy	implicated_in	pathway	0.60
Mitophagy	regulates	pathway	0.60
Differentiation	implicated_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Unfolded Protein Response	implicated_in	pathway	0.60
dementia	associated_with	disease	0.60
ALS	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
SQSTM1	activates	gene	0.60
UFM1	activates	gene	0.60
UVRAG	activates	gene	0.60
UFD1	activates	gene	0.60
VCP	activates	gene	0.60
UFL1	activates	gene	0.60
SQSTM1	co_expressed_with	gene	0.50
UFD1	co_expressed_with	protein	0.50

Incoming (16)

Source	Relation	Type	Str
LC3B	activates	gene	0.60
NPL4	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AMPK	implicated_in	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60
BCL-2	activates	gene	0.60
RPN2	activates	gene	0.60
ATG14	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PIK3C3	activates	gene	0.60
RPL26	activates	gene	0.60
PINK1	regulates	gene	0.60
RPL26	regulates	gene	0.60
PIK3C3	co_expressed_with	gene	0.50
RPL26	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPN1 in their description or question text

No additional research found