gene

RPL26

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

29Outgoing

13Incoming

0Experiments

0Debates

Summary

RPL26 encodes ribosomal protein L26, a component of the 60S ribosomal subunit involved in protein synthesis and extra-ribosomal p53 translation regulation. Dysfunction linked to Diamond-Blackfan anemia, cancers, and neurodegenerative diseases including ALS and Alzheimer disease.

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🧬 Gene Info

Gene Symbol	RPL26
Chromosome	17p13.1.
Protein Type	Transferase
Function	Protein synthesis: RPL26 participates in the peptidyl transferase reaction
Molecular Weight	16.6 kDa
Amino Acids	145 aa
Pathways	Mitophagy
Ensembl ID	ENSG00000137038
GeneCards	RPL26
Human Protein Atlas	RPL26
Associated Diseases	ALS, dementia, frontotemporal, Neonatal Sepsis, Neuropathy
Interactions	ATG14, LC3B, MAP1LC3B, NPL4, PIK3C3, RPN1
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPL26

gene · 1666 words

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Pathway Diagram

graph TD
    RPL26["RPL26"]
    neurodegeneration{"neurodegeneration"}
    RPL26 -->|"implicated_in"| neurodegeneration
    RPN1["RPN1"]
    RPL26 -->|"regulates"| RPN1
    AUTOPHAGY["AUTOPHAGY"]
    RPL26 -->|"implicated_in"| AUTOPHAGY
    PARKIN["PARKIN"]
    RPL26 -->|"regulates"| PARKIN
    Neuropathy{"Neuropathy"}
    RPL26 -->|"implicated_in"| Neuropathy
    Autophagy["Autophagy"]
    RPL26 -->|"implicated_in"| Autophagy
    Mitophagy["Mitophagy"]
    RPL26 -->|"regulates"| Mitophagy
    Differentiation["Differentiation"]
    RPL26 -->|"implicated_in"| Differentiation
    Unfolded_Protein_Response["Unfolded Protein Response"]
    RPL26 -->|"implicated_in"| Unfolded_Protein_Response
    Sin1(["Sin1"])
    RPL26 -->|"binds"| Sin1
    mTORC2(["mTORC2"])
    RPL26 -->|"activates"| mTORC2
    Cell_Growth(["Cell Growth"])
    RPL26 -->|"regulates"| Cell_Growth
    Neonatal_Sepsis(["Neonatal Sepsis"])
    RPL26 -->|"associated_with"| Neonatal_Sepsis
    PINK1["PINK1"]
    PINK1 -->|"regulates"| RPL26
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| RPL26
    AMPK["AMPK"]
    AMPK -->|"implicated_in"| RPL26
    UFM1["UFM1"]
    UFM1 -->|"binds"| RPL26
    UREL["UREL"]
    UREL -->|"binds"| RPL26
    Diamond_Blackfan_Anemia_Syndrome(["Diamond-Blackfan Anemia Syndrome"])
    Diamond_Blackfan_Anemia_Syndrome -->|"associated_with"| RPL26
    style RPL26 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (29)

Target	Relation	Type	Str
Sin1	binds	protein	0.80
mTORC2	activates	pathway	0.80
Cell Growth	regulates	phenotype	0.80
Neuropathy	implicated_in	disease	0.65
AUTOPHAGY	implicated_in	gene	0.60
Autophagy	implicated_in	pathway	0.60
Mitophagy	regulates	pathway	0.60
Differentiation	implicated_in	pathway	0.60
Unfolded Protein Response	implicated_in	pathway	0.60
RPN1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
frontotemporal dementia	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
frontotemporal	associated_with	disease	0.60
UFD1	activates	gene	0.60
UFL1	activates	gene	0.60
ALS	activates	disease	0.60
Neonatal Sepsis	associated_with	disease	0.60
RPN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
UFM1	activates	gene	0.60
UVRAG	activates	gene	0.60
VCP	activates	gene	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
SQSTM1	co_expressed_with	gene	0.50
RPN1	co_expressed_with	gene	0.50

Incoming (13)

Source	Relation	Type	Str
UFM1	binds	protein	0.80
UREL	binds	protein	0.80
Diamond-Blackfan Anemia Syndrome	associated_with	disease	0.80
ATG14	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PIK3C3	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AMPK	implicated_in	gene	0.60
LC3B	activates	gene	0.60
NPL4	activates	gene	0.60
PINK1	regulates	gene	0.60
NPL4	co_expressed_with	protein	0.50
PIK3C3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPL26 in their description or question text

No additional research found