gene

UFM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UFM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

UFM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Aging, Als, Cancer. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UFM1
Full Name	Ubiquitin-like Modifier 1
Function	encodes a ubiquitin-like protein that undergoes unique post-translational modification through ufmylation.
Subcellular Localization	- Cytoplasm, particularly near the ER
Amino Acids	83 aa
Pathways	Autophagy
GeneCards	UFM1
Human Protein Atlas	UFM1
UFM1	The ubiquitin-like modifier itself, encoded by the UFM1 gene
UFC1 (UFM1-conjugating enzyme 1)	An E1-like enzyme that activates UFM1 in an ATP-dependent manner
UFL1 (UFM1 ligase 1)	An E3-like enzyme that facilitates transfer of UFM1 to target proteins
Associated Diseases	Als, Alzheimer, Cancer, dementia, frontotemporal
Interactions	AMPK, ASC1, ATG14, AUTOPHAGY, BECN1, FERROPTOSIS
KG Connections	91 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UFM1["UFM1"]
    Cancer{"Cancer"}
    UFM1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    UFM1 -->|"activates"| Tumor
    UFM1 -->|"regulates"| Cancer
    Als{"Als"}
    UFM1 -->|"regulates"| Als
    UFM1 -->|"interacts with"| Als
    Aging{"Aging"}
    UFM1 -->|"interacts with"| Aging
    UFM1 -->|"interacts with"| Cancer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    UFM1 -->|"interacts with"| Multiple_Sclerosis
    UFM1 -->|"therapeutic target"| Cancer
    UFM1 -->|"expressed in"| Tumor
    ATXN3["ATXN3"]
    UFM1 -->|"regulates"| ATXN3
    BECN1["BECN1"]
    UFM1 -->|"activates"| BECN1
    GENES["GENES"]
    GENES -->|"activates"| UFM1
    LC3B["LC3B"]
    LC3B -->|"regulates"| UFM1
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"regulates"| UFM1
    VCP["VCP"]
    VCP -->|"activates"| UFM1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| UFM1
    AND["AND"]
    AND -->|"associated with"| UFM1
    style UFM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
ASC1	modulates	protein	0.95
Breast Cancer Development	contributes_to	disease	0.90
ASC1	modifies	protein	0.90
ESR1	regulates	protein	0.88
Breast Cancer	involved_in	disease	0.85
RPL26	binds	protein	0.80
Als	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Pyroptosis	interacts_with	pathway	0.60
Unfolded Protein Response	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
Ubiquitin	therapeutic_target	protein	0.60
Ras	activates	protein	0.60
UBIQUITIN	associated_with	gene	0.60
PYROPTOSIS	interacts_with	gene	0.60
Inflammasome	interacts_with	pathway	0.60
GENES	activates	gene	0.60
ATXN3	regulates	gene	0.60
CANCER	associated_with	gene	0.60
BECN1	activates	gene	0.60
Autophagy	activates	pathway	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
NLRP3	interacts_with	gene	0.60
MAVS	associated_with	gene	0.60
SLC7A11	expressed_in	gene	0.60
UVRAG	activates	gene	0.60
LC3B	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
frontotemporal	associated_with	disease	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60

Incoming (32)

Source	Relation	Type	Str
ASC1	associated_with	gene	0.90
UBA5	activates	enzyme	0.85
NPL4	activates	gene	0.60
UFD1	activates	gene	0.60
ATG7	regulates	gene	0.60
ATG14	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PIK3C3	activates	gene	0.60
RPL26	activates	gene	0.60
RPN1	activates	gene	0.60
UFL1	activates	gene	0.60
SQSTM1	activates	gene	0.60
LC3B	activates	gene	0.60
CANCER	activates	entity	0.60
MAP1LC3B	regulates	gene	0.60
VCP	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
BECN1	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
LC3B	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
UBIQUITIN	therapeutic_target	entity	0.60
TAU	associated_with	gene	0.60
AND	contributes_to	gene	0.60
ASC1	activates	gene	0.60
NADH	inhibits	gene	0.60
GENES	contributes_to	gene	0.60
UFD1	co_expressed_with	protein	0.50
UFL1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UFM1 in their description or question text

No additional research found