| Gene Symbol | P53PROTEIN |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | signals The protein functions as a homotetramer, with each monomer containing 3 |
| Amino Acids | 4477 aa |
| GeneCards | P53PROTEIN |
| Human Protein Atlas | P53PROTEIN |
| N-terminal Transactivation Domain (TAD) | Contains two subdomains (TAD1, TAD2) for transcriptional activation |
| Proline-Rich Domain (PRD) | Mediates protein-protein interactions |
| Central DNA-Binding Domain (DBD) | Binds to p53 response elements (p53 RE) as a tetramer |
| Oligomerization Domain (OD) | Forms tetramers essential for DNA binding |
| C-terminal Regulatory Domain (CTD) | Modulates DNA binding and contains nuclear localization signals |
| Cell Cycle Arrest | Activates p21 to halt cell cycle progression |
| [Apoptosis](/entities/apoptosis) | Induces pro-apoptotic genes (BAX, PUMA, NOXA) |
| DNA Repair | Upregulates DNA repair proteins |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | APR-246, chemotherapy, Emodin, MDM2 antagonist Nutlin-3, rapamycin, RAPAMYCIN |
| Interactions | ACAT1, ACETYL-COA, ACOX1, ACSL4, Actin, ACVR2A |
| KG Connections | 2555 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!