protein

MRE11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MRE11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

0Experiments

0Debates

Summary

MRE11 is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with Als, Ataxia, Cancer. Connected to 46 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MRE11
Full Name	MRE11 Homolog, Double Strand Break Repair Nuclease
Chromosome	11q21
Function	MRE11 is a key player in the recognition and processing of DNA double-strand breaks (DSBs), the most cytotoxic form of DNA damage.
Primary Expression	neurons and glia throughout the CNS - High expression in proliferating neural progenitor cells - Essential for genomic stability in neural development
Molecular Weight	81 kDa
Pathways	Immune Response, autophagy pathway
UniProt ID	P43146
Ensembl ID	ENSG00000020922
GeneCards	MRE11
Human Protein Atlas	MRE11
Endonuclease Activity	Cuts DNA internally at damage sites
Exonuclease Activity	Removes nucleotides from DNA ends
Hairpin Opening	Resolves hairpin and loop structures
End Resection	Processes DNA ends for homologous recombination
Associated Diseases	Als, Ataxia, Cancer, Colorectal Cancer, Gastric Cancer, Infection
Interactions	AND, APOPTOSIS, ATM, BAX, Bcl-2, BCL-2
KG Connections	81 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MRE11 — AlphaFold P43146 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MRE11["MRE11"]
    Ataxia{"Ataxia"}
    MRE11 -->|"activates"| Ataxia
    Senescence{"Senescence"}
    MRE11 -->|"interacts with"| Senescence
    Ms{"Ms"}
    MRE11 -->|"interacts with"| Ms
    ATM["ATM"]
    MRE11 -->|"activates"| ATM
    Immune_Response(["Immune Response"])
    MRE11 -->|"activates"| Immune_Response
    MUTYH["MUTYH"]
    MRE11 -->|"interacts with"| MUTYH
    SAMHD1["SAMHD1"]
    MRE11 -->|"interacts with"| SAMHD1
    NBS1["NBS1"]
    MRE11 -->|"interacts with"| NBS1
    LMNA["LMNA"]
    MRE11 -->|"interacts with"| LMNA
    WRN["WRN"]
    MRE11 -->|"interacts with"| WRN
    MDM2["MDM2"]
    MRE11 -->|"interacts with"| MDM2
    CTC1["CTC1"]
    MRE11 -->|"interacts with"| CTC1
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| MRE11
    VCP["VCP"]
    VCP -->|"interacts with"| MRE11
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| MRE11
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| MRE11
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| MRE11
    P53["P53"]
    P53 -->|"interacts with"| MRE11
    POT1["POT1"]
    POT1 -->|"interacts with"| MRE11
    style MRE11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Ataxia	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Infection	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Senescence	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ataxia	activates	disease	0.65
NBS1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
WRN	interacts_with	gene	0.60
MDM2	interacts_with	gene	0.60
CTC1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SYN1	associated_with	gene	0.60
CHEK1	associated_with	gene	0.60
CHMP6	associated_with	gene	0.60
EIF4EBP1	associated_with	gene	0.60
SLC2A1	associated_with	gene	0.60
HDAC8	inhibits	gene	0.60
BAX	inhibits	gene	0.60
Rb	inhibits	protein	0.60
Bcl-2	inhibits	protein	0.60
Immune Response	activates	pathway	0.60
ATM	activates	gene	0.60
Complement	interacts_with	pathway	0.60
MUTYH	interacts_with	gene	0.60
SAMHD1	interacts_with	gene	0.60
MSH6	associated_with	gene	0.60
HDAC2	associated_with	gene	0.60
PMS2	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	regulates	gene	0.60
DNA	associated_with	gene	0.60
Dna Repair	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Microrna	associated_with	pathway	0.60
Mismatch Repair	associated_with	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Epigenetic	associated_with	pathway	0.60
MSH2	associated_with	gene	0.60
MSH3	associated_with	gene	0.60
MLH1	associated_with	gene	0.60
DNA	inhibits	gene	0.60
P53	expressed_in	gene	0.60
Epithelial	inhibits	cell_type	0.60
P21	expressed_in	protein	0.60

Incoming (27)

Source	Relation	Type	Str
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	associated_with	gene	0.60
ARID1A	associated_with	gene	0.60
ACVR2A	associated_with	gene	0.60
ATM	activates	gene	0.60
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
MDC1	associated_with	gene	0.60
ATR	associated_with	gene	0.60
TREX1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
NEIL1	interacts_with	gene	0.60
POLD1	interacts_with	gene	0.60
POT1	interacts_with	gene	0.60
ATR	regulates	gene	0.60
AND	associated_with	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
DNA	regulates	gene	0.60
PARP1	inhibits	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
BCL-2	inhibits	gene	0.60
P21	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MRE11 in their description or question text

No additional research found