protein

CHEK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHEK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

42Outgoing

31Incoming

0Experiments

0Debates

Summary

CHEK1 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Cancer, Ms. Connected to 25 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CHEK1
Full Name	Checkpoint Kinase 1
Chromosome	11q24.2
Protein Type	Serine/Threonine Kinase
Function	CHEK1 (Checkpoint Kinase 1) is a serine/threonine kinase that plays a central role in the DNA damage response (DDR).
Molecular Weight	56 kDa
Amino Acids	476 aa
Pathways	Akt, Pi3K
UniProt ID	CHEK1
Ensembl ID	ENSG00000149554
OMIM	604603
GeneCards	CHEK1
Human Protein Atlas	CHEK1
DNA Damage Checkpoint	Halts cell cycle progression for DNA repair
Replication Fork Stability	Prevents replication fork collapse
Associated Diseases	Als, Ataxia, Infection
Known Drugs/Compounds	Thiabendazole
Interactions	AND, CANCER, CDK1, CDK2, DNA, Egfr
KG Connections	73 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CHEK1 Gene

gene · 501 words

→

CHEK1 Protein

protein · 636 words

→

Pathway Diagram

graph TD
    CHEK1["CHEK1"]
    Cancer{"Cancer"}
    CHEK1 -->|"regulates"| Cancer
    Ms{"Ms"}
    CHEK1 -->|"regulates"| Ms
    MTOR["MTOR"]
    CHEK1 -->|"associated with"| MTOR
    PIK3CA["PIK3CA"]
    CHEK1 -->|"associated with"| PIK3CA
    GSK3B["GSK3B"]
    CHEK1 -->|"associated with"| GSK3B
    AKT["AKT"]
    CHEK1 -->|"regulates"| AKT
    PARP1["PARP1"]
    CHEK1 -->|"associated with"| PARP1
    Pi3K(["Pi3K"])
    CHEK1 -->|"regulates"| Pi3K
    Akt(["Akt"])
    CHEK1 -->|"regulates"| Akt
    Mtor(["Mtor"])
    CHEK1 -->|"associated with"| Mtor
    CANCER["CANCER"]
    CHEK1 -->|"regulates"| CANCER
    CASP3["CASP3"]
    CHEK1 -->|"associated with"| CASP3
    CDK4["CDK4"]
    CDK4 -->|"associated with"| CHEK1
    CASP3 -->|"associated with"| CHEK1
    PI3K["PI3K"]
    PI3K -->|"regulates"| CHEK1
    ABL1["ABL1"]
    ABL1 -->|"associated with"| CHEK1
    ESR1["ESR1"]
    ESR1 -->|"associated with"| CHEK1
    GENES["GENES"]
    GENES -->|"associated with"| CHEK1
    PIK3CA -->|"associated with"| CHEK1
    PARP1 -->|"associated with"| CHEK1
    MTOR -->|"associated with"| CHEK1
    style CHEK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
CDK1	interacts_with	gene	0.60
CDK2	interacts_with	gene	0.60
Pi3K	regulates	pathway	0.60
CANCER	regulates	gene	0.60
Akt	regulates	pathway	0.60
ABL1	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
MTOR	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
AKT	regulates	gene	0.60
PARP1	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
CHMP6	associated_with	gene	0.60
EIF4EBP1	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
SLC2A1	associated_with	gene	0.60
AND	interacts_with	gene	0.60
P53	therapeutic_target	gene	0.60
Egfr	interacts_with	protein	0.60
DNA	associated_with	gene	0.60
EGFR	interacts_with	gene	0.60
ENDOSOME	associated_with	gene	0.60
Cell Cycle	therapeutic_target	pathway	0.60
Cell Cycle	activates	pathway	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
App	therapeutic_target	protein	0.60
P53	activates	gene	0.60

Incoming (31)

Source	Relation	Type	Str
Thiabendazole	binds	drug	0.85
CANCER	activates	gene	0.60
P53	activates	gene	0.60
GSK3B	associated_with	gene	0.60
EGFR	interacts_with	gene	0.60
GENES	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
PIK3CA	associated_with	gene	0.60
PARP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
MDC1	associated_with	gene	0.60
ATR	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	regulates	gene	0.60
MICROTUBULES	associated_with	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
CDK4	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
PI3K	regulates	gene	0.60
ESR1	associated_with	gene	0.60
CDK1	interacts_with	gene	0.60
ABL1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CDK2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHEK1 in their description or question text

No additional research found