gene

MMP9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1873Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

MMP9 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALI, ALS, AMI. Connected to 884 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP9
Chromosome	20q12-13
Protein Family	Matrix metalloproteinase family ( gelatinase B)
Protein Type	Protease
Target Class	Protease
Function	Small molecule zinc-chelating inhibitors or antibody-based inhibition
Mechanism of Action	Small molecule zinc-chelating inhibitors or antibody-based inhibition
Primary Expression	Secreted, extracellular space, neutrophil granules
Druggability	Medium (0.54)
Clinical Stage	Phase III
Molecular Weight	92 kDa (pro-MMP9), 82 kDa (active)
Amino Acids	20 aa
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
UniProt ID	P14780
GeneCards	MMP9
Human Protein Atlas	MMP9
Associated Diseases	acute-on-chronic liver failure, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Andrographis paniculata, curcumin, CURCUMIN, doxycycline, Genistein, GENISTEIN
Interactions	ABCD1, ABCD2, ADAM15, ADAMTS1, AEP, AGING
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	1873 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — MMP9 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1GKC — X-ray / Cryo-EM

🔮 AI Predicted Structure

P14780 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    MMP9(["MMP9"])
    Inflammation["Inflammation"]
    Als["Als"]
    Aging["Aging"]
    Coronary_Artery_Disease["Coronary Artery Disease"]
    Luteolin["Luteolin"]
    neutrophil_extracellular_traps("neutrophil extracellular traps")
    necroptosis("necroptosis")
    autophagy("autophagy")
    h_1acdd55e["h-1acdd55e"]
    MMP9_IN_1{"MMP9-IN-1"}
    GATA4(["GATA4"])
    Akt_Mtor["Akt/Mtor"]
    Mapk["Mapk"]

    MMP9 -->|"therapeutic target"| Inflammation
    MMP9 -->|"activates"| Als
    MMP9 -->|"therapeutic target"| Als
    MMP9 -->|"therapeutic target"| Aging
    MMP9 -->|"biomarker for"| Coronary_Artery_Disease
    Luteolin -.->|"downregulates"| MMP9
    MMP9 -->|"participates in"| neutrophil_extracellular_traps
    MMP9 -->|"associated with"| necroptosis
    MMP9 -.->|"inhibits"| autophagy
    h_1acdd55e -->|"therapeutic target"| MMP9
    MMP9_IN_1 -.->|"inhibits"| MMP9
    GATA4 -.->|"inhibits"| MMP9
    Akt_Mtor -->|"upregulates"| MMP9
    h_1acdd55e -->|"targets gene"| MMP9
    MMP9 -->|"therapeutic target"| Mapk

    style MMP9 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1154)

Target	Relation	Type	Str
Inflammation	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	0.95
Als	activates	disease	0.95
extracellular matrix degradation	mediates	process	0.95
Aging	therapeutic_target	disease	0.95
Coronary Artery Disease	biomarker_for	disease	0.95
cell migration	promotes	process	0.90
glycocalyx	degrades	process	0.90
necroptosis	associated_with	phenotype	0.90
neutrophil extracellular traps	participates_in	phenotype	0.90
autophagy	inhibits	phenotype	0.90
AKT	therapeutic_target	gene	0.90
Autophagy	activates	pathway	0.90
Mapk	therapeutic_target	pathway	0.90
Bone Loss	involved_in	phenotype	0.85
Cancer	therapeutic_target	disease	0.85
Brain Edema	associated_with	phenotype	0.85
Breast Cancer	biomarker_for	disease	0.85
Blood-Brain Barrier Integrity	associated_with	phenotype	0.85
Inflammation	activates	disease	0.85
Cell Metastasis	involved_in	process	0.85
Cancer	activates	disease	0.85
Cancer	inhibits	disease	0.85
vascular barrier integrity	suppresses	phenotype	0.85
Cell Migration	promotes	process	0.85
Type 2 Diabetes Mellitus	biomarker_for	disease	0.80
AQP4	inhibits	protein	0.80
Blood-Brain Barrier Function	associated_with	process	0.80
Non-Small-Cell Lung Cancer	involved_in	disease	0.80
neural stem cells	regulates	cell_type	0.80
neural stem cells	interacts_with	cell_type	0.80
acute-on-chronic liver failure	associated_with	disease	0.80
mortality	contributes_to	phenotype	0.80
Apoptosis	activates	pathway	0.80
NLRP3	activates	protein	0.80
Metastasis	therapeutic_target	pathway	0.80
extracellular matrix	remodels	structure	0.80
CANCER	inhibits	gene	0.80
APOPTOSIS	activates	gene	0.80
CANCER	activates	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80
AUTOPHAGY	activates	gene	0.80
Neurodegeneration	activates	disease	0.75
Cancer	associated_with	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Breast Cancer	inhibits	disease	0.75

Incoming (719)

Source	Relation	Type	Str
genes-mmp9	documents	wiki_page	1.00
Luteolin	downregulates	compound	0.95
MMP2	co_mentioned_with	gene	0.90
Akt/Mtor	upregulates	pathway	0.90
HB147	downregulates	compound	0.90
h-1acdd55e	targets_gene	hypothesis	0.90
Litebamine	downregulates	compound	0.90
GATA4	inhibits	protein	0.90
MMP9-IN-1	inhibits	drug	0.90
Timp-1	inhibits	protein	0.90
Hu-Loaded Exosomes	downregulates	compound	0.90
GENES	therapeutic_target	gene	0.90
TNF	therapeutic_target	gene	0.90
NFKB1	upregulates	protein	0.85
CURCUMIN	targets	drug	0.85
FB23	downregulates	drug	0.85
AKT/MTOR Signaling Pathway	upregulates	pathway	0.85
H3K56Ac	regulates	biomarker	0.85
cardamom nanoemulsion	downregulates	compound	0.85
H3K27Ac	regulates	biomarker	0.85
Genistein	binds	compound	0.85
IL1B	upregulates	protein	0.85
IL-6	associated_with	gene	0.82
TNF	upregulates	pathway	0.80
Qingqi Liangying formula	downregulates	drug	0.80
C9ORF72	upregulates	gene	0.80
Andrographis paniculata	inhibits	drug	0.80
UVB	contributes_to	drug	0.80
h-1acdd55e	targets	hypothesis	0.80
p65	activates	protein	0.80
NDRG2	upregulates	gene	0.80
IL-6	interacts_with	protein	0.80
PI3K	therapeutic_target	gene	0.80
AKT1	therapeutic_target	gene	0.80
GENES	implicated_in	gene	0.80
MMP2	inhibits	gene	0.80
INFLAMMATION	activates	gene	0.80
TNF	associated_with	gene	0.74
IL-1B	associated_with	gene	0.74
IRN	inhibits	drug	0.72
LUTEOLIN	regulates	drug	0.72
MMP9_IN1	inhibits	drug	0.72
STAT3	regulates	protein	0.72
OSTEOCLASTS	expressed_in	cell_type	0.72
IGF1	associated_with	gene	0.70
APP	targets	gene	0.70
CGAS	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
ASTROCYTE	expresses	cell_type	0.70
MMP2	expresses	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

MMP9

Understanding Entity Pages

Summary

Wiki Pages (3)

MMP9 Protein

MMP9 Protein

MMP9 Gene

Pathway Diagram

Outgoing (1154)

Incoming (719)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Can circadian interventions reverse microglial priming independent of sleep disr

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senolytic therapy for age-related neurodegeneration

Experiments (0)

Related Papers (0)

Debates (3)

Can circadian interventions reverse microglial priming independent of sleep disr

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc