concept

PI3K/AKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1944Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PI3K/AKT is a concept in neurodegeneration research. Key relationships include: regulates, inhibits, protects against. Associated with Alzheimer's disease, cerebral ischemia-reperfusion injury. Connected to 28 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PI3K/AKT
Key Genes/Proteins	ABCB1, ACSL4, AKT, AMPK, ANGPT1, ANXA1
Related Diseases	Adult Dermatomyositis, Alzheimer's disease

Wiki Pages (1)

Knowledge base pages for this entity

PI3K/AKT/mTOR Signaling Pathway in Neurodegeneration

mechanism · 1115 words

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Pathway Diagram

graph TD
    PI3K_AKT["PI3K/AKT"]
    PI3K_AKT -->|"activates"| neuronal_survival["neuronal survival"]
    PI3K_AKT -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    PI3K_AKT -->|"activates"| oxidative_stress_resistance["oxidative stress resistance"]
    PI3K_AKT -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT -->|"regulates"| mTOR["mTOR"]
    PI3K_AKT -.protects against.-> oxidative_stress["oxidative stress"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| autophagy["autophagy"]
    NF2["NF2"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rg1["Ginsenoside Rg1"] -->|"activates"| PI3K_AKT
    acupuncture["acupuncture"] -->|"regulates"| PI3K_AKT
    CCL21["CCL21"] -->|"activates"| PI3K_AKT
    AMPK["AMPK"] -->|"interacts"| PI3K_AKT
    merlin["merlin"] -->|"regulates"| PI3K_AKT
    Rb1["Rb1"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rb1["Ginsenoside Rb1"] -->|"activates"| PI3K_AKT
    THBS2["THBS2"] -->|"regulates"| PI3K_AKT

Outgoing (274)

Target	Relation	Type	Str
ischemic stroke	regulates	disease	0.95
Aerobic Glycolysis	promotes	process	0.95
Cancer	activates	disease	0.95
NRF2	activates	protein	0.95
osteoblast pyroptosis	inhibits	process	0.92
Renal Tubular Epithelial Cell Apoptosis	mediates	process	0.92
MTOR	activates	gene	0.90
Hemorrhagic Stroke	implicated_in	disease	0.90
Polystyrene Microplastics	inhibits	compound	0.90
Programmed Cell Death	regulates	process	0.90
Inflammation	regulates	process	0.90
Cardiomyocyte apoptosis	inhibits	process	0.90
Autophagy	regulates	process	0.90
Lipid Metabolism	regulates	process	0.90
glucose metabolism	regulates	process	0.90
Cellular Survival	regulates	process	0.90
Proteostasis	regulates	process	0.90
PKM2	phosphorylates	protein	0.90
HK2	phosphorylates	protein	0.90
GLUT1	phosphorylates	protein	0.90
SLC2A1	phosphorylates	gene	0.90
cell migration	promotes	process	0.90
cell proliferation	promotes	process	0.90
PFKFB3	phosphorylates	gene	0.90
depression	therapeutic_target	disease	0.90
cell invasion	promotes	process	0.90
emotion-related brain regions	expressed_in	brain_region	0.88
APOPTOSIS	regulates	process	0.88
Dermatomyositis	upregulates	disease	0.88
Apoptosis	inhibits	process	0.88
Epithelial-Mesenchymal Transition	regulates	process	0.85
Apoptosis	inhibits	process	0.85
Cytokines	regulates	compound	0.85
Blood-Brain Barrier Integrity	regulates	process	0.85
HIF1A	regulates	gene	0.85
GSK3	regulates	protein	0.85
FOXO	regulates	protein	0.85
VASCULAR BARRIER FUNCTION	promotes	biological_process	0.85
MTOR	regulates	gene	0.85
MYC	regulates	gene	0.85
MTORC1	regulates	protein	0.85
mTOR	activates	protein	0.85
rheumatoid arthritis	associated_with	disease	0.85
PENTOSE PHOSPHATE PATHWAY	regulates	entity	0.85
LIPID SYNTHESIS	regulates	entity	0.85
OXIDATIVE STRESS	regulates	entity	0.85
Lithium Neurotoxicity	involved_in	process	0.85
Adult Dermatomyositis	upregulates	disease	0.85
neurogenesis	regulates	process	0.85
oxidative stress	modulates	process	0.85

Incoming (1670)

Source	Relation	Type	Str
Cancer	associated_with	disease	1.00
AKT	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
MTOR	associated_with	gene	1.00
CANCER	associated_with	gene	1.00
APOPTOSIS	inhibits	gene	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
TNF	activates	gene	1.00
BCL-2	therapeutic_target	gene	1.00
ERK	inhibits	gene	1.00
PI3K	therapeutic_target	gene	1.00
TNF-Α	activates	gene	1.00
PI3K	inhibits	gene	1.00
NF-ΚB	activates	gene	1.00
Als	inhibits	disease	1.00
Cancer	regulates	disease	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
INFLAMMATION	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
AKT	inhibits	gene	1.00
Aging	activates	disease	1.00
APOPTOSIS	regulates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
Inflammation	activates	disease	1.00
Tumor	inhibits	disease	1.00
AKT	therapeutic_target	gene	1.00
CANCER	inhibits	gene	1.00
NRF2	activates	gene	1.00
Cancer	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	regulates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Breast Cancer	therapeutic_target	disease	1.00
Neuroinflammation	activates	disease	1.00
EGFR	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
GENES	inhibits	gene	1.00
PI3K	activates	gene	1.00
Tumor	activates	disease	1.00
AKT	activates	gene	1.00
HIF	activates	gene	1.00
CANCER	activates	gene	1.00
Carcinoma	activates	disease	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
DNA	activates	gene	1.00

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT in their description or question text

No additional research found