gene

NRXN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRXN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

45Outgoing

30Incoming

0Experiments

0Debates

Summary

NRXN3 is a gene implicated in neurodegeneration research. Key relationships include: protects against, inhibits, implicated in. Associated with Als, Inflammation, Neurodegeneration. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRXN3
Chromosome	14q31.1.
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	cerebral cortex (layer 2/3 pyramidal neurons), hippocampus (CA1-CA3, dentate gyrus), striatum (
Molecular Weight	180 kDa
Exons	24
Pathways	Oxidative Stress, Sod1
GeneCards	NRXN3
Human Protein Atlas	NRXN3
Associated Diseases	ALS, Alzheimer
Interactions	Bdnf, BDNF, CAT, COX4I1, CYCS, GENES
KG Connections	75 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NRXN3 Gene

gene · 639 words

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NRXN3 Protein

protein · 816 words

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Pathway Diagram

graph TD
    NRXN3["NRXN3"]
    ALS["ALS"]
    NEURODEGENERATION["Neurodegeneration"]
    NEUROINFLAMMATION["Neuroinflammation"]
    OXIDATIVE_STRESS["Oxidative Stress"]
    BDNF["BDNF"]
    SOD1["SOD1"]
    SOD2["SOD2"]
    NLGN2["NLGN2"]
    PSD95["PSD95"]
    PRKAA1["PRKAA1 (AMPK)"]
    PDHA1["PDHA1"]
    CYCS["CYCS (Cytochrome C)"]
    CREB["CREB"]
    SYNAPTIC_FUNCTION["Synaptic Function"]
    MITOCHONDRIAL_DYSFUNCTION["Mitochondrial Dysfunction"]
    
    NRXN3 -->|"protects against"| ALS
    NRXN3 -->|"protects against"| NEURODEGENERATION
    NRXN3 -->|"protects against"| NEUROINFLAMMATION
    NRXN3 -->|"inhibits"| OXIDATIVE_STRESS
    NRXN3 -->|"inhibits"| BDNF
    NRXN3 -->|"inhibits"| SOD1
    NRXN3 -->|"protects"| SOD2
    NRXN3 -->|"interacts with"| NLGN2
    NRXN3 -->|"protects"| PSD95
    NRXN3 -->|"inhibits"| PRKAA1
    NRXN3 -->|"inhibits"| PDHA1
    NRXN3 -->|"inhibits"| CYCS
    NRXN3 -->|"protects"| CREB
    
    NLGN2 -->|"maintains"| SYNAPTIC_FUNCTION
    PSD95 -->|"supports"| SYNAPTIC_FUNCTION
    PDHA1 -->|"contributes to"| MITOCHONDRIAL_DYSFUNCTION
    CYCS -->|"triggers"| MITOCHONDRIAL_DYSFUNCTION
    OXIDATIVE_STRESS -->|"promotes"| NEUROINFLAMMATION
    MITOCHONDRIAL_DYSFUNCTION -->|"leads to"| NEURODEGENERATION
    
    style NRXN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style SOD2 fill:#1b5e20
    style PSD95 fill:#1b5e20
    style CREB fill:#1b5e20
    style SYNAPTIC_FUNCTION fill:#1b5e20
    style ALS fill:#7d4200
    style NEURODEGENERATION fill:#7d4200
    style NEUROINFLAMMATION fill:#ef5350
    style OXIDATIVE_STRESS fill:#ef5350
    style MITOCHONDRIAL_DYSFUNCTION fill:#ef5350
    style BDNF fill:#4a1a6b
    style SOD1 fill:#4a1a6b
    style NLGN2 fill:#4a1a6b
    style PRKAA1 fill:#4a1a6b
    style PDHA1 fill:#4a1a6b
    style CYCS fill:#4a1a6b

Outgoing (45)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Rb	inhibits	protein	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
NRXN1	regulates	gene	0.60
Presenilin	regulates	protein	0.60
Bdnf	inhibits	protein	0.60
NLGN2	inhibits	gene	0.60
PSD95	protects_against	gene	0.60
CYCS	inhibits	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
AKT	protects_against	gene	0.60
NLGN1	interacts_with	protein	0.60
major depressive disorder	contributes_to	disease	0.60
NRXN2	regulates	gene	0.60
NLGN1	regulates	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GENES	inhibits	gene	0.60
CREB	protects_against	gene	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PER	protects_against	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
PDHA1	inhibits	gene	0.60
Sod1	inhibits	pathway	0.60
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NRXN1	interacts_with	protein	0.50
oxidative stress	inhibits	phenotype	0.50

Incoming (30)

Source	Relation	Type	Str
SLC2A1	inhibits	gene	0.60
NRXN2	regulates	gene	0.60
NRXN1	regulates	gene	0.60
NLGN2	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
AKT	protects_against	gene	0.60
BDNF	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
CYCS	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
PKM	inhibits	gene	0.60
GLUT4	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
SLC2A2	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
COX4I1	inhibits	gene	0.60
NLGN1	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
CAT	inhibits	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
PER	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
NLGN1	interacts_with	gene	0.55
NRXN1	interacts_with	gene	0.55
NRXN2	interacts_with	gene	0.50
PRKAA1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRXN3 in their description or question text

No additional research found