gene

NPM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

295Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

2Debates

Summary

Nucleophosmin - a multifunctional nucleolar phosphoprotein involved in ribosome biogenesis, DNA repair, p53 regulation, and nucleolar stress response in neurodegeneration

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🧬 Gene Info

Gene Symbol	NPM1
Aliases	Nucleophosmin
Chromosome	5q35.1
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule modulators of nucleolar function and protein interactions
Mechanism of Action	Small molecule modulators of nucleolar function and protein interactions
Subcellular Localization	, shuttling between the nucleolus, nucleoplasm, and cytoplasm in response to cellular stress conditions. This traffickin
Druggability	Low (0.30)
Clinical Stage	Phase III
Molecular Weight	37 kDa
Amino Acids	294 aa
Exons	12
Pathways	Apoptosis
UniProt ID	A0A7I2V5J8
Ensembl ID	ENSG00000126016
GeneCards	NPM1
Human Protein Atlas	NPM1
Associated Diseases	Acute Myeloid Leukemia, Als, cancer
Known Drugs/Compounds	NSC348884
Interactions	AMYOTROPHIC LATERAL SCLEROSIS, AND, ARHGEF2, ARID1A, C9ORF72, CANCER
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Nucleolar Stress Response Normalization
KG Connections	295 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NPM1 — AlphaFold A0A7I2V5J8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NPM1 Gene

gene · 983 words

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Pathway Diagram

graph TD
    NPM1["NPM1"]
    NPM1 -->|"binds"| DNA["DNA"]
    NPM1 -.biomarker for.-> Leukemia["Leukemia"]
    NPM1 -.biomarker for.-> Ms["Ms"]
    NPM1 -->|"expressed in"| Als["Als"]
    NPM1 -->|"target for"| Cancer["Cancer"]
    NPM1 -->|"activates"| Tumor["Tumor"]
    h_ecacd219["h-ecacd219"] -->|"target for"| NPM1
    XPO1["XPO1"] -->|"inhibits"| NPM1
    GENES["GENES"] -->|"expressed in"| NPM1
    NLRC5["NLRC5"] -->|"activates"| NPM1
    IRF1["IRF1"] -->|"activates"| NPM1
    CIITA["CIITA"] -->|"activates"| NPM1
    DNA -->|"activates"| NPM1
    CD8["CD8"] -->|"activates"| NPM1
    NOTCH2NLC["NOTCH2NLC"] -->|"activates"| NPM1

Outgoing (228)

Target	Relation	Type	Str
Antigen Presentation	inhibits	process	0.95
Acute Myeloid Leukemia	causes	disease	0.95
Tumor Progression	associated_with	process	0.95
Immune Evasion	associated_with	process	0.95
Acute Myeloid Leukemia	associated_with	disease	0.95
neuronal viability	regulates	phenotype	0.90
Cd8+ T Cell Activation	inhibits	process	0.90
cytoplasmic delocalization	causes	process	0.90
Cd8+ T Cell Infiltration	inhibits	process	0.90
Nucleus	transports	cell_type	0.90
IRF1	associated_with	protein	0.90
AML Development	involved_in	process	0.90
Cytoplasm	transports	cell_type	0.90
AML Progression	involved_in	process	0.90
Myeloid cell	expressed_in	cell_type	0.88
Acute Myeloid Leukemia	therapeutic_target	disease	0.88
cell proliferation	regulates	process	0.85
Survival Rate	correlates_with	phenotype	0.85
ribosome biogenesis	regulates	process	0.85
Tumor Microenvironment Reprogramming	regulates	process	0.85
IRF1	interacts_with	protein	0.85
AML progression	contributes_to	process	0.85
Immunosuppressive Cell Infiltration	promotes	process	0.85
nucleolus	expressed_in	cell_type	0.85
MHC-I	downregulates	protein	0.85
MHC-II	downregulates	protein	0.85
Nucleophosmin Function	mediates	process	0.85
Leukemic cell development	involved_in	process	0.82
genomic stability	regulates	process	0.80
embryonic development	associated_with	process	0.80
neurodegeneration	regulates	process	0.80
Measurable Residual Disease	biomarker_for	phenotype	0.80
preleukemic clonal hematopoiesis	involved_in	process	0.80
Cancer	biomarker_for	disease	0.80
OTHER MUTATIONS	interacts_with	gene	0.80
Treatment response in AML	associated_with	phenotype	0.80
neurodegenerative diseases	therapeutic_target	disease	0.80
Preleukemic Clonal Hematopoiesis	associated_with	process	0.80
Measurable Residual Disease	associated_with	biomarker	0.80
Tumor Microenvironment Reprogramming	modulates	process	0.80
Cell Nuclear Function	involved_in	process	0.80
Tumor Antigen Presentation	inhibits	process	0.80
AML prognosis	modulates	phenotype	0.80
nucleolar_function	regulates	pathway	0.80
Nucleolar function	regulates	process	0.78
cancer	associated_with	disease	0.75
programmed cell death	regulates	process	0.75
HOX GENES	regulates	gene	0.75
Patient Survival	correlates_with	phenotype	0.75
DNA	binds	entity	0.70

Incoming (67)

Source	Relation	Type	Str
h-ecacd219	targets	hypothesis	0.90
DNA	activates	gene	0.60
GENES	expressed_in	gene	0.60
GENES	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
CANCER	associated_with	entity	0.60
RNA	associated_with	gene	0.60
NLRC5	activates	gene	0.60
IRF1	activates	gene	0.60
CIITA	activates	gene	0.60
CD8	activates	gene	0.60
NOTCH2NLC	activates	gene	0.60
ENO1	associated_with	gene	0.60
IRF1	interacts_with	entity	0.60
ARID1A	activates	gene	0.60
ARID1A	expressed_in	gene	0.60
HNRNPA1	interacts_with	gene	0.60
MLL	inhibits	gene	0.60
MHC-I	activates	gene	0.60
IRF2BP2	associated_with	gene	0.60
G3BP1	activates	gene	0.60
LMNA	interacts_with	gene	0.60
RNA	regulates	gene	0.60
angiogenesis	activates	process	0.60
CANCER	causes	gene	0.60
IRF2BP2	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ALS	therapeutic_target	gene	0.60
XPO1	inhibits	gene	0.60
MYC	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
PRDX1	interacts_with	gene	0.60
ARHGEF2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
ARHGEF2	associated_with	entity	0.60
LMNA	associated_with	entity	0.60
DNA	regulates	gene	0.60
DNA	interacts_with	gene	0.60
AND	activates	gene	0.60
AND	causes	gene	0.60
CR1	activates	gene	0.60
CR1	associated_with	gene	0.60
KDM5B	activates	gene	0.60
KMT2A	inhibits	gene	0.60
FUS	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Nucleolar Stress Response Normalization	0.653	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
NPM1 knockout tumor progression study in syngeneic mice	validation	cancer	0.900	0.00	syngeneic mice with subcutaneo	proposed	N/A
NPM1-IRF1 protein interaction validation	exploratory	cancer	0.900	0.00	cultured cells	proposed	N/A
In vitro T-cell killing assay with OVA-presenting tumor cells	exploratory	cancer	0.800	0.00	OVA-presenting tumor cells and	proposed	N/A
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	completed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629]	Wang X, Chai Y, Quan Y, Wang J, Song J,	J Hematol Oncol	2024	1
Significance of NPM1 Gene Mutations in AML. [PMID:34576201]	Hindley A, Catherwood MA, McMullin MF, M	Int J Mol Sci	2021	1
NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823]	Falini B, Brunetti L, Sportoletti P, Mar	Blood	2020	1
Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633]	Pfister JA, D'Mello SR	Exp Biol Med (Maywood)	2015	1
Functions of the histone chaperone nucleolin in diseases. [PMID:17484127]	Storck S, Shukla M, Dimitrov S, Bouvet P	Subcell Biochem	2007	1
Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypome [PMID:41035402]	Short NJ, Loghavi S, Yilmaz M, Karrar O,	Haematologica	2026	0
A Unified Model: Chromatin-Bound Multicomponent Condensates. [PMID:41481253]	Lau BK, Haarer EL, Ahn JH, Wang GG	Cancer Res	2026	0
Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to [PMID:41923577]	Bruzzese A, Vigna E, Martino EA, Caserta	Eur J Haematol	2026	0
Response to Comment on: "Prognostic implications of myelodysplasia-related gene [PMID:41924903]	Chang YS, Hou HA	Haematologica	2026	0
Fibrillarin: bridging ribosome biogenesis and apoptosis in cellular stress and d [PMID:41518572]	["Zhang Z", "Zhang M", "Cao Z", "Zhao H"	Apoptosis : an international j	2026	0
Probing condensate microenvironments with a micropeptide killswitch. [PMID:40468084]	Zhang Y, Stöppelkamp I, Fernandez-Pernas	Nature	2025	0
Functions of the native NPM1 protein and its leukemic mutant. [PMID:39690184]	Falini B, Sorcini D, Perriello VM, Sport	Leukemia	2025	0
Spatial resolution of cellular senescence dynamics in human colorectal liver met [PMID:37157887]	["Garbarino O", "Lambroia L", "Basso G",	Aging cell	2023	0
Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of [PMID:34134693]	["Beji S", "D'Agostino M", "Gambini E",	BMC biology	2021	0
The nucleolus functions as a phase-separated protein quality control compartment [PMID:31296649]	Frottin F, Schueder F, Tiwary S, Gupta R	Science (New York, N.Y.)	2019	0
Small nucleoli are a cellular hallmark of longevity. [PMID:28853436]	["Tiku V", "Jain C", "Raz Y", "Nakamura	Nature communications	2017	0
Repression of rRNA transcription by PARIS contributes to Parkinson's disease. [PMID:25315684]	["Kang H", "Shin J"]	Neurobiology of disease	2015	0
How Parkinson's disease meets nucleolar stress. [PMID:24412806]	["Parlato R", "Liss B"]	Biochimica et biophysica acta	2014	0
Activation of an endogenous suicide response after perturbation of rRNA synthesi [PMID:19036968]	["Parlato R", "Kreiner G", "Erdmann G",	The Journal of neuroscience :	2008	0
Stress inhibits nucleocytoplasmic shuttling of heat shock protein hsc70. [PMID:15930140]	["Kodiha M", "Chu A", "Lazrak O", "Stoch	American journal of physiology	2005	0

Debates (2)

Multi-agent debates referencing this entity

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.72 · 2026-04-12

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.88 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NPM1 in their description or question text

No additional research found