gene

ATR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

3Experiments

1Debates

Summary

ATR is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATR
Protein Type	Kinase
Function	encodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011].
Pathways	mTOR, mtor, mTOR signaling, PI3K
GeneCards	ATR
Human Protein Atlas	ATR
Associated Diseases	Als, Ataxia, Cancer, Infection, Ms, Senescence
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AND, APOPTOSIS, ARID1A, ATG5, ATM
KG Connections	208 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    APE2["APE2"] -->|"participates in"| ATR["ATR"]
    ATM["ATM"] -->|"interacts with"| ATR["ATR"]
    ATR["ATR"] -->|"activates"| Fibrosis["Fibrosis"]
    ATR["ATR"] -->|"associated with"| Cancer["Cancer"]
    ATR["ATR"] -->|"associated with"| Als["Als"]
    ATR["ATR"] -->|"associated with"| Ataxia["Ataxia"]
    ATR["ATR"] -->|"activates"| Cardiac["Cardiac"]
    ATR["ATR"] -->|"associated with"| Ms["Ms"]
    ATR["ATR"] -->|"regulates"| Aging["Aging"]
    ATR["ATR"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ATR["ATR"] -->|"regulates"| Als["Als"]
    ATR["ATR"] -->|"regulates"| Cancer["Cancer"]
    style APE2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ATR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ATM fill:#006494,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (144)

Target	Relation	Type	Str
RFWD3	phosphorylates	gene	0.85
Cancer	inhibits	disease	0.75
Tumor	regulates	disease	0.75
Als	regulates	disease	0.75
CANCER	inhibits	gene	0.70
Infection	associated_with	disease	0.65
Breast Cancer	inhibits	disease	0.65
Senescence	implicated_in	disease	0.65
Longevity	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ataxia	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Ms	associated_with	disease	0.65
Senescence	contributes_to	disease	0.65
BRCA2	regulates	gene	0.60
ATM	regulates	gene	0.60
ATM	therapeutic_target	gene	0.60
AIM2	contributes_to	gene	0.60
ATM	interacts_with	gene	0.60
FANCC	interacts_with	gene	0.60
FANCE	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
PP2A	activates	gene	0.60
BCL2	activates	gene	0.60
DNA	associated_with	gene	0.60
Oxidative Stress	activates	pathway	0.60
Inflammasome	contributes_to	pathway	0.60
Er Stress	contributes_to	pathway	0.60
Neuron	contributes_to	cell_type	0.60
Apoptosis	associated_with	pathway	0.60
ATM	associated_with	gene	0.60
HNRNPH1	regulates	gene	0.60
Mtor	inhibits	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
Immune Checkpoint	inhibits	pathway	0.60
CANCER	therapeutic_target	gene	0.60

Incoming (64)

Source	Relation	Type	Str
APE2	participates_in	gene	0.90
ATM	interacts_with	protein	0.70
DNA	interacts_with	gene	0.60
CGAS-STING	contributes_to	gene	0.60
FANCI	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60
P53	regulates	gene	0.60
CANCER	regulates	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
ATM	phosphorylates	gene	0.60
ARID1A	inhibits	gene	0.60
PI3K	regulates	gene	0.60
ATM	regulates	gene	0.60
NBN	associated_with	gene	0.60
TPX2	inhibits	gene	0.60
ATM	inhibits	gene	0.60
MDC1	associated_with	gene	0.60
DNA	inhibits	gene	0.60
RNA	activates	gene	0.60
P53	inhibits	gene	0.60
P21	inhibits	gene	0.60
ATM	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
TIGAR	inhibits	gene	0.60
FANCC	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
FANCE	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
ATG5	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
ERK	inhibits	gene	0.60
KRAS	regulates	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AND	inhibits	gene	0.60
RAD54	activates	gene	0.60
VCP	activates	gene	0.60
RAD51	activates	gene	0.60
FNDC5	activates	gene	0.60
SIRT6	regulates	gene	0.60
PARP1	regulates	gene	0.60
HNRNPA1	regulates	gene	0.60
MYC	regulates	gene	0.60
DDX5	regulates	gene	0.60
PIN1	regulates	gene	0.60
BRCA1	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In	0.709	neurodegeneration	Perivascular spaces and glymphatic clear
Extracellular Matrix Stiffness Modulation	0.691	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Age-Stratified Ketone Dosing Matrix	0.452	metabolic neuroscience	What determines the optimal timing and d

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microglial activation by bEVs via Piezo1	exploratory	Alzheimer's disease	0.900	0.00	microglia (in vivo and in vitr	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690]	Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G	Fish Shellfish Immunol	2025	1
Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284]	Xu Q, Ma L, Streuer A, Altrock E, Schmit	Cell Commun Signal	2025	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920]	Sun H, Wu Z, Zhang Y, Liu C, Gao D et al	Osteoarthritis Cartilage	2026	0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513]	Ma J, Xie N, Wang Z, Liang X, Han Y et a	Adv Sci (Weinh)	2026	0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798]	Zhang M, Ge Y, Wang Z, Li H, Wang G et a	Neurosci Biobehav Rev	2026	0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045]	Pillai EK, Mukherjee S, Gampl N, McGinn	Nat Mater	2026	0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354]	Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a	MedComm (2020)	2026	0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265]	["Li R", "Xia J", "Shi C", "Zhang K", "Q	Journal of advanced research	2026	0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938]	Wang H, Gou Z, Chen S, Lu L	The International journal of n	2026	0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420]	Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li	Frontiers in molecular bioscie	2025	0
Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked [PMID:40465757]	["Ventura-Antunes L", "Nackenoff A", "Ro	Alzheimer's & dementia : the j	2025	0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683]	Gupta T, Singh TG, Singh R	Molecular biology reports	2025	0
LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic [PMID:39260063]	["Jiang D", "Zhao J", "Zheng J", "Zhao Y	Redox biology	2024	0
Cardiomyocyte senescence and the potential therapeutic role of senolytics in the [PMID:39119147]	["Zhai P", "Sadoshima J"]	The journal of cardiovascular	2024	0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281]	Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi	Cell	2024	0

Debates (1)

Multi-agent debates referencing this entity

The authors explicitly state that the effects of these novel genes (MATR3, CHCHD

closed · Rounds: 4 · Score: 0.71 · 2026-04-14

Related Research

Hypotheses and analyses mentioning ATR in their description or question text

No additional research found

ATR

Understanding Entity Pages

Summary

Wiki Pages (10)

ATR Gene

ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-Linked

MATR3 Protein

ATRX Protein

MATR3 Gene

ATRIP

ATR Protein

HEATR1 Protein

HEATR1 Gene

MATRIN3 Protein