gene

MMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

794Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MMP2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 317 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP2
Full Name	Matrix Metallopeptidase 2
Chromosome	16q13
Protein Type	Protease
Target Class	Protease
Function	MMP-2 (gelatinase A) degrades gelatin (denatured collagen), type IV collagen, and elastin.
Mechanism of Action	Small molecule zinc-chelating inhibitors of metalloprotease activity
Primary Expression	neurons, astrocytes, microglia, and endothelial cells where it regulates synaptic plasticity, blood-brain
Druggability	Medium (0.46)
Clinical Stage	Phase III
Molecular Weight	73.9 kDa
Amino Acids	660 aa
Pathways	Akt, Amyloid, Nf-Κb, Pi3K, Sleep-Wake Cycle
UniProt ID	P08253
Ensembl ID	ENSG00000196547
GeneCards	MMP2
Human Protein Atlas	MMP2
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Melatonin
Interactions	ADAMTS1, AEP, AGING, AGO2, AKT, AKT1
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	794 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MMP2 — AlphaFold P08253 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MMP2 Gene

gene · 515 words

→

MMP2 Protein

protein · 871 words

→

Pathway Diagram

graph TD
    MMP2["MMP2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    MMP2["MMP2"] -->|"interacts"| MMP9["MMP9"]
    MMP2["MMP2"] -->|"co discussed"| C3["C3"]
    MMP2["MMP2"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    MMP2["MMP2"] -->|"co discussed"| DNASE2["DNASE2"]
    MMP2["MMP2"] -->|"co discussed"| STING1["STING1"]
    MMP9_1["MMP9"] -->|"interacts"| MMP2["MMP2"]
    MMP9_2["MMP9"] -->|"co discussed"| MMP2["MMP2"]
    SLC7A11["SLC7A11"] -->|"co discussed"| MMP2["MMP2"]
    AQP4["AQP4"] -->|"co discussed"| MMP2["MMP2"]
    style MMP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (445)

Target	Relation	Type	Str
extracellular matrix degradation	mediates	process	0.95
cell migration	promotes	process	0.90
MMP9	associated_with	gene	0.90
glomerular endothelial ultrastructure	degrades	process	0.85
Cell Migration	promotes	process	0.85
Cancer	therapeutic_target	disease	0.85
Alzheimer's Disease	associated_with	disease	0.85
Breast Cancer	biomarker_for	disease	0.85
Brain Edema	associated_with	phenotype	0.85
Cerebral Cortex	expressed_in	brain_region	0.80
Non-Small-Cell Lung Cancer	involved_in	disease	0.80
interstitial fibrosis and tubular atrophy	contributes_to	phenotype	0.80
endothelial barrier integrity	suppresses	process	0.80
Blood-Brain Barrier Function	associated_with	process	0.80
MMP9	inhibits	gene	0.80
perineuronal nets	degrades	structure	0.80
Tumor	inhibits	disease	0.75
Alzheimer'S Disease	associated_with	disease	0.75
Tumor	activates	disease	0.75
ECM_DEGRADATION	regulates	phenotype	0.72
MMP9	expressed_in	gene	0.70
VEGF	activates	gene	0.70
SIRT1	inhibits	gene	0.70
NRF2	inhibits	gene	0.70
RAGE	regulates	gene	0.70
MMP9	targets	gene	0.70
MMP9	biomarker_for	gene	0.70
RAGE	targets	gene	0.70
VEGF	expressed_in	gene	0.70
CANCER	targets	gene	0.70
neural stem cells	interacts_with	cell_type	0.70
NF-kB signaling	participates_in	pathway	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Wnt signaling	participates_in	pathway	0.70
TIMP2	inhibits	gene	0.70
neural stem cells	activates	cell_type	0.70
Melatonin	involved_in	drug	0.70
MMP9	treats	gene	0.70
Ms	inhibits	disease	0.65
Ms	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Stroke	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Aging	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Fibrosis	associated_with	disease	0.65

Incoming (349)

Source	Relation	Type	Str
Timp-1	inhibits	protein	0.90
h-1acdd55e	targets	hypothesis	0.90
Litebamine	downregulates	compound	0.90
Hu-Loaded Exosomes	downregulates	compound	0.90
HB68	downregulates	compound	0.90
Theranekron	downregulates	drug	0.88
cardamom nanoemulsion	downregulates	compound	0.85
FB23	downregulates	drug	0.85
NFKB1	upregulates	protein	0.85
Melatonin	targets	drug	0.80
PPARGC1A	inhibits	gene	0.80
IGF1	inhibits	gene	0.70
ENDOTHELIAL	associated_with	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
APP	targets	gene	0.70
STAT3	activates	gene	0.70
APOPTOSIS	regulates	phenotype	0.70
BAX	activates	gene	0.70
MICROGLIA	activates	cell_type	0.70
OXIDATIVE STRESS	causes	phenotype	0.70
MICROGLIA	regulates	cell_type	0.70
TIMP2	regulates	gene	0.70
TIMP2	activates	gene	0.70
YAP	regulates	protein	0.68
NF-KB	associated_with	protein	0.66
ALZHEIMER'S DISEASE	associated_with	gene	0.66
ERK	phosphorylates	gene	0.65
ERK	activates	gene	0.65
NRF2	targets	gene	0.65
SENESCENCE	inhibits	phenotype	0.65
KCNK2	regulates	gene	0.64
WWOX	activates	gene	0.60
VEGFA	therapeutic_target	gene	0.60
VIM	expressed_in	gene	0.60
PTGS2	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CXCL8	associated_with	gene	0.60
DNA	causes	gene	0.60
CYP1A1	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
INS	interacts_with	gene	0.60
ICAM1	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
AEP	activates	gene	0.60
DNA	disrupts	gene	0.60
CCND1	interacts_with	gene	0.60
DNA	regulates	gene	0.60
DNA	inhibits	gene	0.60
EXERCISE	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning MMP2 in their description or question text

No additional research found