gene

NLGN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

Summary

NLGN2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, protects against, associated with. Associated with Als, Anxiety, Inflammation. Connected to 51 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NLGN2
Full Name	Neuroligin 2
Chromosome	17p13.1
Function	Synapse Formation: Mediates formation of GABAergic and glycinergic synapses through interaction with presynaptic neurexins.
Subcellular Localization	**: Postsynaptic membranes, dendritic shafts
Molecular Weight	156 kDa
Amino Acids	411 aa
Exons	19
UniProt ID	Q9NZU5
NCBI Gene ID	54587
Ensembl ID	ENSG00000144048
OMIM	607629
GeneCards	NLGN2
Human Protein Atlas	NLGN2
Associated Diseases	Migraine
Interactions	ANXIETY, Bdnf, BDNF, CAT, COX4I1, CYCS
KG Connections	92 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NLGN2 — AlphaFold Q9NZU5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NLGN2 Gene

gene · 735 words

→

NLGN2 Protein

protein · 900 words

→

Pathway Diagram

graph TD
    NLGN2["NLGN2"]
    Als{"Als"}
    NLGN2 -->|"inhibits"| Als
    Anxiety{"Anxiety"}
    NLGN2 -->|"inhibits"| Anxiety
    Schizophrenia{"Schizophrenia"}
    NLGN2 -->|"inhibits"| Schizophrenia
    Ms{"Ms"}
    NLGN2 -->|"inhibits"| Ms
    Migraine{"Migraine"}
    NLGN2 -->|"associated with"| Migraine
    CDK4["CDK4"]
    NLGN2 -->|"associated with"| CDK4
    CHD4["CHD4"]
    NLGN2 -->|"associated with"| CHD4
    HMGCR["HMGCR"]
    NLGN2 -->|"associated with"| HMGCR
    TGFB3["TGFB3"]
    NLGN2 -->|"associated with"| TGFB3
    DISC1["DISC1"]
    NLGN2 -->|"inhibits"| DISC1
    AND["AND"]
    NLGN2 -->|"inhibits"| AND
    neurodegeneration["neurodegeneration"]
    NLGN2 -->|"implicated in"| neurodegeneration
    DISC1 -->|"inhibits"| NLGN2
    ERBB4["ERBB4"]
    ERBB4 -->|"inhibits"| NLGN2
    GENES["GENES"]
    GENES -->|"inhibits"| NLGN2
    GLUD1["GLUD1"]
    GLUD1 -->|"inhibits"| NLGN2
    NRG1["NRG1"]
    NRG1 -->|"inhibits"| NLGN2
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| NLGN2
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| NLGN2
    TP53["TP53"]
    TP53 -->|"associated with"| NLGN2
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| NLGN2
    FXN["FXN"]
    FXN -->|"associated with"| NLGN2
    EPHA5["EPHA5"]
    EPHA5 -->|"associated with"| NLGN2
    EP300["EP300"]
    EP300 -->|"associated with"| NLGN2
    style NLGN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
Anxiety	inhibits	disease	0.65
Schizophrenia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
ALS	protects_against	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Migraine	associated_with	disease	0.65
Neuron	inhibits	cell_type	0.60
Bdnf	inhibits	protein	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PER	protects_against	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
PSD95	protects_against	gene	0.60
CYCS	inhibits	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
AKT	protects_against	gene	0.60
PDHA1	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
NRXN3	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
Sod1	inhibits	pathway	0.60
PKM	inhibits	gene	0.60
CHD4	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
TGFB3	associated_with	gene	0.60
DISC1	inhibits	gene	0.60
CDK4	associated_with	gene	0.60
GEPHYRIN	interacts_with	gene	0.60
NLGN1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
PAX6	expressed_in	gene	0.60
SMARCA4	expressed_in	gene	0.60
SNAP25	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
GENES	inhibits	gene	0.60
Neuron	expressed_in	cell_type	0.55
SYNAPSE	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
NEURONS	inhibits	concept	0.50

Incoming (39)

Source	Relation	Type	Str
GENES	inhibits	gene	0.70
ANXIETY	inhibits	gene	0.60
ADNP	expressed_in	gene	0.60
NLGN1	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
PKM	inhibits	gene	0.60
GLUT4	protects_against	gene	0.60
PER	protects_against	gene	0.60
DISC1	inhibits	gene	0.60
ERBB4	inhibits	gene	0.60
GLUD1	inhibits	gene	0.60
NRG1	inhibits	gene	0.60
KCNK5	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
NR1D1	associated_with	gene	0.60
FXN	associated_with	gene	0.60
EPHA5	associated_with	gene	0.60
EP300	associated_with	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
CYCS	inhibits	gene	0.60
CREB	protects_against	gene	0.60
SYNAPSE	inhibits	gene	0.60
NRXN3	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NLGN1	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GEPHYRIN	interacts_with	gene	0.50
Sod1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLGN2 in their description or question text

No additional research found