concept

INSR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INSR
Key Genes/Proteins	ABCB1, ADH1B, AGING, AKT, AKT1, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER
Related Pathways	Akt

Wiki Pages (2)

Knowledge base pages for this entity

Insulin Receptor (INSR) Neurons

cell · 983 words

→

Insulin Receptor (INSR) Protein

protein · 631 words

→

Pathway Diagram

graph TD
    INSR["INSR"]
    INSR -->|"encodes"| Insulin_receptor["Insulin receptor"]
    INSR -->|"interacts"| Ms["Ms"]
    INSR -->|"interacts"| Cancer["Cancer"]
    INSR -->|"interacts"| Tumor["Tumor"]
    INSR -->|"inhibits"| Pancreatic_Cancer["Pancreatic Cancer"]
    INSR -->|"inhibits"| Diabetes["Diabetes"]
    INSR -->|"inhibits"| Inflammation["Inflammation"]
    INSR -->|"inhibits"| Obesity["Obesity"]
    IGF1["IGF1"] -->|"regulates"| INSR
    IGF1R["IGF1R"] -->|"regulates"| INSR
    PI3K["PI3K"] -->|"interacts"| INSR
    PIK3CA["PIK3CA"] -->|"interacts"| INSR
    MMP9["MMP9"] -->|"target for"| INSR
    PPARA["PPARA"] -->|"target for"| INSR
    RELA["RELA"] -->|"interacts"| INSR
    AKT1["AKT1"] -->|"target for"| INSR
    INFLAMMATION["INFLAMMATION"] -->|"inhibits"| INSR

Outgoing (80)

Target	Relation	Type	Str
Insulin receptor	encodes	protein	0.70
ALZHEIMER	associated_with	disease	0.70
Tumor	interacts_with	disease	0.65
ALS	protects_against	disease	0.65
Als	protects_against	disease	0.65
PI3K	regulates	gene	0.65
Alzheimer	protects_against	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
PI3K	treats	gene	0.65
PI3K	protects_against	gene	0.65
PI3K	targets	gene	0.65
Type 2 Diabetes	inhibits	disease	0.65
Pancreatic Cancer	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Type 2 Diabetes	expressed_in	disease	0.65
Insulin Resistance	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
PI3K	inhibits	gene	0.60
BDNF	expressed_in	gene	0.60
RAS	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
EXOSOMES	expressed_in	gene	0.60
Mapk	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
INSULIN RESISTANCE	expressed_in	gene	0.60
EXERCISE	expressed_in	gene	0.60
ALZHEIMER	protects_against	gene	0.60
GASTRODIN	activates	gene	0.60
Mapk	interacts_with	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CANCER	interacts_with	gene	0.60
Ngf	activates	protein	0.60
Pi3K	interacts_with	pathway	0.60
NGF	activates	gene	0.60
ROS	protects_against	gene	0.60
Pi3K/Akt	activates	pathway	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
PI3K	activates	gene	0.60

Incoming (41)

Source	Relation	Type	Str
NGF	targets	gene	0.65
DEMENTIA	expressed_in	gene	0.60
KRAS	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OVERVIEW	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
GASTRODIN	activates	gene	0.60
AKT	activates	gene	0.60
ALZHEIMER	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
NGF	activates	gene	0.60
ROS	protects_against	gene	0.60
AND	activates	gene	0.60
AKT	co_discussed	gene	0.60
ABCB1	activates	gene	0.60
APOD	activates	gene	0.60
COL4A1	activates	gene	0.60
IGF1	regulates	gene	0.60
IGF1R	regulates	gene	0.60
PI3K	interacts_with	gene	0.60
PIK3CA	interacts_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
IGF1R	therapeutic_target	gene	0.60
RELA	interacts_with	gene	0.60
AKT1	therapeutic_target	gene	0.60
ADH1B	regulates	gene	0.60
APOE	regulates	gene	0.60
FTO	regulates	gene	0.60
AQP5	biomarker_for	gene	0.60
CLCN1	causes	gene	0.55
DMPK	causes	gene	0.55
ATP2A1	protects_against	gene	0.55
CLCN1	protects_against	gene	0.55
OBESITY	associated_with	disease	0.50
NAFLD	associated_with	disease	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
Pi3K	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INSR in their description or question text

No additional research found