gene

ENO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

0Experiments

0Debates

Summary

ENO1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Breast Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ENO1
Full Name	Enolase 1 (Alpha-enolase)
Chromosome	1p36.23
Function	encodes a 433-amino acid protein (approximately 47 kDa).
Subcellular Localization	the cell surface
Molecular Weight	47 kDa
Amino Acids	433 aa
Pathways	Apoptosis, Autophagy, Glycolysis, Immune Response, Inflammasome
UniProt ID	P06733
NCBI Gene ID	2023
Ensembl ID	ENSG00000169064
OMIM	172430
GeneCards	ENO1
Human Protein Atlas	ENO1
N-terminal domain (aa 1-150)	Involved in dimerization and protein-protein interactions with various binding partners
Associated Diseases	Aging, Cancer, Carcinoma, Ms, Parkinson, Tumor
Interactions	AND, APOPTOSIS, ATP, CANCER, CD4, C-MYC
KG Connections	156 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ENO1 — AlphaFold P06733 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ENO1 Gene

gene · 1055 words

→

ENO1 Protein

protein · 777 words

→

Pathway Diagram

graph TD
    ENO1["ENO1"]
    glycolysis(["glycolysis"])
    ENO1 -->|"participates in"| glycolysis
    Aging{"Aging"}
    ENO1 -->|"associated with"| Aging
    Ms{"Ms"}
    ENO1 -->|"associated with"| Ms
    ENO1 -->|"biomarker for"| Ms
    Als{"Als"}
    ENO1 -->|"biomarker for"| Als
    Parkinson{"Parkinson"}
    ENO1 -->|"associated with"| Parkinson
    Cancer{"Cancer"}
    ENO1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    ENO1 -->|"associated with"| Tumor
    Carcinoma{"Carcinoma"}
    ENO1 -->|"associated with"| Carcinoma
    ENO1 -->|"regulates"| Ms
    DDX5["DDX5"]
    ENO1 -->|"associated with"| DDX5
    CD8["CD8"]
    ENO1 -->|"associated with"| CD8
    AGING["AGING"]
    AGING -->|"associated with"| ENO1
    PSMB9["PSMB9"]
    PSMB9 -->|"associated with"| ENO1
    style ENO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (109)

Target	Relation	Type	Str
glycolysis	participates_in	pathway	0.90
Glycolysis	regulates	pathway	0.70
Hepatocellular Carcinoma	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Infection	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Sepsis	activates	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Tumor	regulates	disease	0.65
Breast Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
HSPA1A	interacts_with	gene	0.60
FLT1	interacts_with	gene	0.60
HSPA8	interacts_with	gene	0.60
GPX4	biomarker_for	gene	0.60
DNAJA1	biomarker_for	gene	0.60
HK2	activates	gene	0.60
PDK1	activates	gene	0.60
MYC	activates	gene	0.60
Mitosis	activates	pathway	0.60
PDK3	activates	gene	0.60
Nf-Κb	associated_with	pathway	0.60
FERROPTOSIS	biomarker_for	gene	0.60
Ferroptosis	biomarker_for	pathway	0.60
Erk Signaling	activates	pathway	0.60
Differentiation	activates	pathway	0.60
MAP2K1	biomarker_for	gene	0.60
VCAM1	biomarker_for	gene	0.60
LMNA	biomarker_for	gene	0.60
GAPDH	interacts_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
Epigenetic	associated_with	pathway	0.60

Incoming (47)

Source	Relation	Type	Str
ANXA5	expressed_in	gene	0.60
CCND1	expressed_in	gene	0.60
PSMB9	associated_with	gene	0.60
AND	interacts_with	gene	0.60
LDHB	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
ERK	activates	gene	0.60
RAS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
DNA	activates	gene	0.60
LDHA	activates	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
GENES	activates	gene	0.60
GLUT1	activates	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
PGK1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
TKT	regulates	gene	0.60
FBP1	regulates	gene	0.60
TP53	regulates	gene	0.60
PDK1	regulates	gene	0.60
CD4	activates	gene	0.60
E2F1	activates	gene	0.60
GAPDH	interacts_with	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
HSPA4	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
MYC	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ROS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
ATP	inhibits	gene	0.60
CANCER	regulates	gene	0.60
GENES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENO1 in their description or question text

No additional research found