gene

P2RX7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

638Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

8Experiments

7Debates

Summary

P2RX7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 135 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX7
Full Name	Purinergic Receptor P2X Ligand-Gated Ion Channel 7
Chromosome	12
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Selective P2X7 receptor antagonists blocking ATP-gated ion channel
Mechanism of Action	Selective P2X7 receptor antagonists blocking ATP-gated ion channel
Druggability	High (0.80)
Clinical Stage	Phase II
Molecular Weight	68.6 kDa
Amino Acids	595 aa
Pathways	Glucose Metabolism, Lipid Metabolism, Phagocytosis, tau accumulation, tau propagation
UniProt ID	Q99572
NCBI Gene ID	10278
Ensembl ID	ENSG00000088038
OMIM	601636
GeneCards	P2RX7
Human Protein Atlas	P2RX7
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	therapeutic_target
Interactions	ACHE, AD, adora2b, ADORA2B, Alpha-Synuclein, ALPHA-SYNUCLEIN
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	P2RX7-Mediated Exosome Secretion Blockade
KG Connections	638 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — P2RX7 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5U1L — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q99572 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

P2RX7 Gene

gene · 2363 words

→

P2RX7 Protein

protein · 1727 words

→

Pathway Diagram

graph TD
    P2RX7["P2RX7"] -->|"associated"| neurodegeneration["neurodegeneration"]
    P2RX7["P2RX7"] -->|"interacts"| P2RY1["P2RY1"]
    P2RX7["P2RX7"] -->|"co discussed"| DGAT1["DGAT1"]
    P2RX7["P2RX7"] -->|"co discussed"| C3["C3"]
    P2RX7["P2RX7"] -->|"co discussed"| AQP4["AQP4"]
    P2RX7["P2RX7"] -->|"co discussed"| EPHB4["EPHB4"]
    P2RY1_1["P2RY1"] -->|"interacts"| P2RX7["P2RX7"]
    BMAL1["BMAL1"] -->|"co discussed"| P2RX7["P2RX7"]
    HK2["HK2"] -->|"co discussed"| P2RX7["P2RX7"]
    MIRO1["MIRO1"] -->|"co discussed"| P2RX7["P2RX7"]
    style P2RX7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (364)

Target	Relation	Type	Str
LUNG TISSUE	expressed_in	entity	0.95
UPREGULATES	upregulates	entity	0.95
Extracellular Vesicles	regulates	mechanism	0.95
Glucose Homeostasis	regulates	phenotype	0.93
PANCREATIC B-CELLS	expressed_in	entity	0.90
extracellular nucleotide signaling	involved_in	pathway	0.90
purinergic signaling	involved_in	pathway	0.90
GLUCOSE HOMEOSTASIS	regulates	entity	0.90
Brain Atrophy	contributes_to	phenotype	0.90
Neurodegeneration	contributes_to	process	0.90
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
IMMUNE CELLS	expressed_in	entity	0.90
pancreatic beta cells	expressed_in	cell_type	0.88
COVID-19	upregulates	disease	0.85
Glucose Homeostasis	associated_with	process	0.85
Diabetes	risk_factor_for	disease	0.85
Lung Tissue	expressed_in	cell_type	0.85
Glycemic Traits	associated_with	phenotype	0.80
neurons	expressed_in	cell_type	0.80
Glucose Metabolism	regulates	pathway	0.80
Type 2 Diabetes Mellitus	associated_with	disease	0.75
Type 2 Diabetes	associated_with	disease	0.75
STING	activates	gene	0.70
STING	causes	gene	0.70
VEGF	activates	gene	0.70
P2RY12	inhibits	gene	0.70
P2RY1	interacts_with	gene	0.66
neurodegeneration	associated_with	disease	0.66
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Anxiety	inhibits	disease	0.65
TAU	inhibits	gene	0.65
TAU	mediates	gene	0.65
TAU	impairs	gene	0.65
exosome_secretion	regulates	pathway	0.65
Covid	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Aging	activates	disease	0.65
Tauopathy	regulates	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Depression	associated_with	disease	0.65

Incoming (274)

Source	Relation	Type	Str
PMID_31187411	no_GWAS_AD_association	publication	0.00
H3	antagonizes	hypothesis	0.00
h-1333080b	targets_gene	hypothesis	0.90
h-0758b337	targets	hypothesis	0.80
NLRP3	expressed_in	gene	0.70
CCL2	expresses	gene	0.70
OLIGODENDROCYTE	expresses	cell_type	0.70
OLIGODENDROCYTES	expresses	cell_type	0.70
OLIGODENDROCYTES	inhibits	cell_type	0.70
OLIGODENDROCYTE	inhibits	cell_type	0.70
MICROGLIA	expressed_in	cell_type	0.70
ASTROCYTE	expresses	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
HSP90	activates	gene	0.70
HSP90	expresses	gene	0.70
ACHE	activates	gene	0.70
NEURONS	inhibits	cell_type	0.70
GPX4	activates	gene	0.70
P2RY1	interacts_with	gene	0.66
EPILEPSY	associated_with	disease	0.65
IL18	inhibits	gene	0.65
P2X7	inhibits	gene	0.65
ATP	inhibits	gene	0.65
ENTORHINAL CORTEX	inhibits	brain_region	0.65
ATP	transports	gene	0.60
EGFR	contributes_to	gene	0.60
IL-1	activates	gene	0.60
HMOX1	contributes_to	gene	0.60
APP	expressed_in	gene	0.60
TAUOPATHY	regulates	gene	0.60
SERPINE1	contributes_to	gene	0.60
HSP90AA1	expressed_in	gene	0.60
SLC17A9	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
SNCA	interacts_with	gene	0.60
SCN10A	associated_with	gene	0.60
INPP4A	associated_with	gene	0.60
EGFR	biomarker_for	gene	0.60
HMOX1	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
HSP90AA1	associated_with	gene	0.60
NT5E	associated_with	gene	0.60
IL18	regulates	gene	0.60
ASTROCYTE	inhibits	cell_type	0.60
CA1	inhibits	brain_region	0.60
CORTEX	inhibits	brain_region	0.60
ENTORHINAL	inhibits	brain_region	0.60
HIPPOCAMPUS	inhibits	brain_region	0.60
MICROGLIA	causes	cell_type	0.60
NEURON	expressed_in	cell_type	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
P2RX7-Mediated Exosome Secretion Blockade	0.552	neurodegeneration	Tau propagation mechanisms and therapeut
P2RX7-PANX1 Channel Blockade for Neuroinflammatory Cascade I	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
P2RX7 variant rs1718119 association with glucose homeostasis in Botnia	exploratory	type 2 diabetes	0.900	human patients	proposed	N/A
P2rx7 genetic deletion in PS19 tauopathy mice	validation	Alzheimer's disease/tauopathy	0.900	PS19 tauopathy mice	proposed	N/A
P2rx7 congenic mouse model insulin tolerance testing	validation	insulin resistance	0.900	congenic mice (C57BL6 P2rx7 al	proposed	N/A
P2rx7 congenic mouse model glucose tolerance testing	validation	glucose intolerance	0.900	congenic mice (C57BL6 P2rx7 al	proposed	N/A
Single-cell RNA sequencing of mouse brains	exploratory	Alzheimer's disease/tauopathy	0.900	PS19 mouse brain tissue	proposed	N/A
Cell type-specific P2rx7 deletion in microglia vs astrocytes	validation	Alzheimer's disease/tauopathy	0.850	PS19 mice with cell type-speci	proposed	N/A
Brain-derived extracellular vesicles proteome analysis	exploratory	Alzheimer's disease/tauopathy	0.850	Brain-derived extracellular ve	proposed	N/A
BDEV injection and recipient microglial transcriptome analysis	validation	Alzheimer's disease/tauopathy	0.800	Recipient mice injected with B	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P2RX7 in their description or question text

No additional research found