gene

CCL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CCL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 131 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CCL3
Aliases	MIP-1α, LD78β
Chromosome	17q12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various cell types including: - Activated macrophages and monocytes - T cells and B cells - Neurons and glial cells (in CNS) - En
Molecular Weight	10 kDa
Amino Acids	99 aa
Pathways	Akt, Amyloid, Autophagy, Chaperone, Exocytosis
UniProt ID	P10147
Ensembl ID	ENSG00000108175
OMIM	182283
GeneCards	CCL3
Human Protein Atlas	CCL3
Associated Diseases	Als, Alzheimer, Cancer, Dementia, Inflammation, Ms
Known Drugs/Compounds	GW201
Interactions	AGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	303 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CCL3 — AlphaFold P10147 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CCL3 Gene

gene · 583 words

→

CCL3 Protein

protein · 621 words

→

Pathway Diagram

graph TD
    CCL3["CCL3"]
    CCL3 -->|"activates"| CCR5["CCR5"]
    CCL3 -->|"upregulates"| IL1B["IL1B"]
    CCL3 -->|"upregulates"| TREM2["TREM2"]
    CCL3 -->|"activates"| Migraine["Migraine"]
    CCL3 -->|"activates"| Ms["Ms"]
    CCL3 -->|"activates"| Inflammation["Inflammation"]
    CCL3 -->|"activates"| Aging["Aging"]
    CCL3 -->|"activates"| Huntington["Huntington"]
    CCL3 -->|"activates"| Tauopathy["Tauopathy"]
    CCL3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PANX1["PANX1"] -->|"regulates"| CCL3
    S100B["S100B"] -->|"regulates"| CCL3
    RELB["RELB"] -->|"regulates"| CCL3
    P2RY1["P2RY1"] -->|"regulates"| CCL3
    CASP3["CASP3"] -->|"regulates"| CCL3
    SOCS3["SOCS3"] -->|"regulates"| CCL3
    TRPA1["TRPA1"] -->|"regulates"| CCL3
    GENES["GENES"] -->|"regulates"| CCL3
    CXCL2["CXCL2"] -->|"regulates"| CCL3
    SNAP25["SNAP25"] -->|"regulates"| CCL3

Outgoing (215)

Target	Relation	Type	Str
CCR5	activates	gene	0.90
IL1B	upregulates	gene	0.80
Inflammation	associated_with	disease	0.75
inflammatory response	promotes	process	0.75
TREM2	upregulates	gene	0.70
TNF-Α	activates	gene	0.70
Macrophage	associated_with	cell_type	0.70
Prostate Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Senescence	activates	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Melanoma	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Hepatitis	activates	disease	0.65
Depression	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Huntington	activates	disease	0.65
Tauopathy	activates	disease	0.65
Als	regulates	disease	0.65
Migraine	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Autoimmune	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
CXCL10	expressed_in	gene	0.60
CXCR3	expressed_in	gene	0.60
CCR2	expressed_in	gene	0.60

Incoming (88)

Source	Relation	Type	Str
GW201	modulates	compound	0.85
GW201	downregulates	compound	0.80
TLR2	associated_with	gene	0.60
CCL5	associated_with	gene	0.60
APP	associated_with	gene	0.60
GENES	regulates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60
JAK	activates	gene	0.60
TLR	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
CCL2	activates	gene	0.60
VEGF	associated_with	gene	0.60
TNF	associated_with	gene	0.60
OSMR	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CCL5	activates	gene	0.60
CCL4	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
CX3CR1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
C3	associated_with	gene	0.60
MTORC1	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ASTROCYTES	activates	gene	0.60
GENES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ERK1	activates	gene	0.60
P38	activates	gene	0.60
CGAS	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
CCL2	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
PRESENILIN	associated_with	gene	0.60
CCL2	expressed_in	gene	0.60
AKT	activates	gene	0.60
C1Q	activates	gene	0.60
CXCR3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCL3 in their description or question text

No additional research found