gene

APOA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

295Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

APOA1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with AD, ALS, AMI. Connected to 93 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	APOA1
Full Name	Apolipoprotein A1
Chromosome	Chr11q23.3
Function	The APOA1 gene encodes Apolipoprotein A1, the primary protein component of high-density lipoprotein (HDL) particles.
UniProt ID	P02647
NCBI Gene ID	335
Ensembl ID	ENSG00000118137
OMIM	107680
GeneCards	APOA1
Human Protein Atlas	APOA1
Associated Diseases	AD, Als, Alzheimer, AMI, ARM
Interactions	4E-BP1, ABCA1, abca2, ABCA2, ABCG1, ACTB
KG Connections	295 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APOA1 — AlphaFold P02647 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

APOA1 Gene

gene · 748 words

→

APOA1 Protein

protein · 605 words

→

Pathway Diagram

graph TD
    APOA1["APOA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    APOA1["APOA1"] -->|"interacts"| Als["Als"]
    APOA1["APOA1"] -->|"activates"| Ms["Ms"]
    APOA1["APOA1"] -->|"activates"| Atherosclerosis_1["Atherosclerosis"]
    APOA1["APOA1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    APOA1["APOA1"] -->|"therapeutic target"| Als_2["Als"]
    RPL17["RPL17"] -->|"regulates"| APOA1["APOA1"]
    ACTB["ACTB"] -->|"interacts"| APOA1["APOA1"]
    P2RY12["P2RY12"] -.->|"inhibits"| APOA1["APOA1"]
    SOAT1["SOAT1"] -->|"activates"| APOA1["APOA1"]
    style APOA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (208)

Target	Relation	Type	Str
Blastocyst Formation	involved_in	process	0.90
Cell Differentiation	involved_in	process	0.90
LIPID METABOLISM	involved_in	entity	0.85
ALS	interacts_with	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Tumor	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Atherosclerosis	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Als	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Atherosclerosis	degrades	disease	0.65
Ms	activates	disease	0.65
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60
TAU	degrades	gene	0.60
LIPA	degrades	gene	0.60
Cholesterol	expressed_in	pathway	0.60
Lipid Metabolism	expressed_in	pathway	0.60
PER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
MAPT	degrades	gene	0.60
TFCP2	degrades	gene	0.60
NR1H3	regulates	entity	0.60
PLIN2	regulates	entity	0.60
SOAT1	regulates	entity	0.60
AKT	inhibits	gene	0.60
ACTB	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60

Incoming (87)

Source	Relation	Type	Str
RPL17	regulates	gene	0.80
APOD	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
MTOR	inhibits	gene	0.60
AKT	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
APOE4	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
APOC2	associated_with	gene	0.60
MCC	associated_with	gene	0.60
CAT	associated_with	gene	0.60
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
LRP8	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
PER	therapeutic_target	gene	0.60
ACOX1	associated_with	gene	0.60
GENES	activates	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
MAO	inhibits	gene	0.60
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
CD36	activates	gene	0.60
PON1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
SERPINE1	therapeutic_target	gene	0.60
LC3	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
ULK1	interacts_with	gene	0.60
ABCG1	interacts_with	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
ABCA1	activates	entity	0.60
ABCG1	activates	entity	0.60
ACTB	activates	entity	0.60
TLR4	activates	gene	0.60
SREBF1	degrades	gene	0.60
CYP46A1	activates	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60
LRP1	activates	gene	0.60
NCSTN	degrades	gene	0.60
LDLR	activates	gene	0.60
LDL	interacts_with	gene	0.60
AND	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APOA1 in their description or question text

No additional research found