concept

APP/PS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APP/PS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1315Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

APP/PS1 is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, Aging, Als. Connected to 440 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	APP/PS1
Key Genes/Proteins	ABCA1, ABCA7, ACHE, ACSL4, Actin, ADAM10
Related Diseases	acetylcholine, Aging
Related Pathways	Akt

Wiki Pages (2)

Knowledge base pages for this entity

APP/PS1 Double Transgenic Mouse Model

mechanism · 1702 words

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APP/PS1 Dual Transgenic Mouse Model

model · 661 words

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Pathway Diagram

graph TD
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    APP_PS1 -->|"regulates"| Alzheimer["Alzheimer"]
    APP_PS1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    APP_PS1 -->|"regulates"| Ms["Ms"]
    APP_PS1 -->|"regulates"| Als["Als"]
    APP_PS1 -->|"inhibits"| Dementia["Dementia"]
    MICROGLIA["MICROGLIA"] -->|"regulates"| APP_PS1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| APP_PS1
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| APP_PS1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| APP_PS1
    P62["P62"] -->|"regulates"| APP_PS1
    LAMP1["LAMP1"] -->|"regulates"| APP_PS1
    RHOA["RHOA"] -->|"regulates"| APP_PS1
    PDE4B["PDE4B"] -->|"inhibits"| APP_PS1

Outgoing (781)

Target	Relation	Type	Str
APP/PS1	encodes	protein	0.00
Alzheimer	activates	disease	1.00
APP	inhibits	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Inflammation	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
MICROGLIA	activates	gene	1.00
APP	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
Als	activates	disease	1.00
AMYLOID	activates	gene	1.00
Aging	activates	disease	0.95
Alzheimer	treats	disease	0.95
Neurodegeneration	activates	disease	0.95
Alzheimer	protects_against	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.90
Amyloid plaque load	associated_with	biomarker	0.90
Cognitive Impairment	causes	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
NEURON	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
Autophagy	activates	pathway	0.90
Apoptosis	activates	pathway	0.90
AMYLOID	inhibits	gene	0.90
ALZHEIMER	treats	gene	0.90
ALZHEIMER'S DISEASE	treats	gene	0.90
ALZHEIMER	protects_against	gene	0.90
Neuroinflammation	treats	disease	0.85
Alzheimer	associated_with	disease	0.85
Inflammation	treats	disease	0.85
Amyloid Deposition	causes	phenotype	0.85
Neuroinflammation	inhibits	disease	0.85
Inflammation	inhibits	disease	0.85
NEUROINFLAMMATION	treats	gene	0.80
NEUROINFLAMMATION	inhibits	gene	0.80
ALZHEIMER'S DISEASE	protects_against	gene	0.80
Apoptosis	inhibits	pathway	0.80
SIRT3	activates	gene	0.80
ALZHEIMER	associated_with	gene	0.80
AGING	activates	gene	0.80
Nf-Κb	activates	pathway	0.80
LC3	activates	gene	0.80
NF-ΚB	activates	gene	0.80
APP	protects_against	gene	0.80
GENES	activates	gene	0.80
Inflammasome	activates	pathway	0.80
Mitophagy	activates	pathway	0.80
AMPK	activates	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80

Incoming (534)

Source	Relation	Type	Str
APP/PS1	encodes	gene	0.00
APOPTOSIS	activates	gene	1.00
NLRP3	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
APP	associated_with	gene	0.80
Chronic Cerebral Hypoperfusion	contributes_to	process	0.80
APOPTOSIS	inhibits	gene	0.80
AUTOPHAGY	activates	gene	0.80
MITOPHAGY	activates	gene	0.80
TAU	activates	gene	0.80
TLR4	activates	gene	0.80
AMYLOID	activates	gene	0.70
APP	activates	gene	0.70
TNF	inhibits	gene	0.70
BMAL1	expressed_in	gene	0.70
NEURODEGENERATION	protects_against	gene	0.70
ROS	activates	gene	0.70
SIRT3	activates	gene	0.60
GSK3A	activates	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
MICROGLIA	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	activates	gene	0.60
LC3	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
TAU	treats	gene	0.60
GFP	activates	gene	0.60
BAX	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
AMYLOID	interacts_with	gene	0.60
GAS6	activates	gene	0.60
DCX	activates	gene	0.60
LYSOSOME	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
HO-1	activates	gene	0.60
VDR	activates	gene	0.60
CREB	activates	gene	0.60
PSD95	activates	gene	0.60
TAU	regulates	gene	0.60
DEPRESSION	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
DJ-1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APP/PS1 in their description or question text

No additional research found