gene

PON1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PON1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections
0Hypotheses
0Analyses
31Outgoing
15Incoming
0Experiments
0Debates

Summary

PON1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Als, Atherosclerosis, Breast Cancer. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPON1
Chromosome7q21.3.
Protein TypeEnzyme
Functionis a calcium-dependent esterase enzyme encoded by the PON1 gene on chromosome 7q21.
Primary Expressionthe liver (hepatocytes) and secreted into plasma
Molecular Weight43 kDa
Amino Acids354 aa
UniProt IDP27169
NCBI Gene ID5444
Ensembl IDENSG00000005421
OMIM168000
GeneCardsPON1
Human Protein AtlasPON1
LDL protectionPrevents copper-catalyzed oxidation of low-density lipoprotein
HDL associationTightly bound to apoA-I on HDL particles
Associated DiseasesAls, Atherosclerosis, Breast Cancer, Cancer, Depression, Inflammation
InteractionsCLU
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PON1 — AlphaFold P27169 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PON1 — Paraoxonase 1

gene · 1782 words

Pathway Diagram

graph TD
    PON1["PON1"]
    Carcinoma{"Carcinoma"}
    PON1 -->|"therapeutic target"| Carcinoma
    Als{"Als"}
    PON1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    PON1 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    PON1 -->|"therapeutic target"| Tumor
    IGF1["IGF1"]
    PON1 -->|"therapeutic target"| IGF1
    PER["PER"]
    PON1 -->|"therapeutic target"| PER
    SERPINE1["SERPINE1"]
    PON1 -->|"therapeutic target"| SERPINE1
    APOA1["APOA1"]
    PON1 -->|"therapeutic target"| APOA1
    PPARGC1A["PPARGC1A"]
    PON1 -->|"therapeutic target"| PPARGC1A
    ESR1["ESR1"]
    PON1 -->|"therapeutic target"| ESR1
    neurodegeneration["neurodegeneration"]
    PON1 -->|"implicated in"| neurodegeneration
    style PON1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

TargetRelationTypeStr
Strokeassociated_withdisease0.75
GENESassociated_withgene0.70
APOEassociated_withgene0.70
STROKEassociated_withgene0.70
Lipid Metabolismassociated_withpathway0.70

Incoming (15)

SourceRelationTypeStr
OXIDATIVE STRESScausesgene0.60
CANCERcausesgene0.60
ALOX12associated_withgene0.60
CLUactivatesgene0.60
ANDtherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PON1 in their description or question text

No additional research found