gene

JAK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

0Experiments

0Debates

Summary

JAK3 (Janus Kinase 3) is a non-receptor tyrosine kinase essential for cytokine receptor signaling, primarily in lymphoid cells. It plays critical roles in immune function and neuroinflammation in the CNS.

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🧬 Gene Info

Gene Symbol	JAK3
Full Name	Janus Kinase 3
Protein Type	Receptor
Function	encodes a non-receptor tyrosine kinase that plays essential roles in cytokine receptor signaling, particularly in lymphoid cells.
Primary Expression	microglia and astrocytes, where it mediates cytokine-driven inflammatory response
Amino Acids	1124 aa
Pathways	JAK-STAT signaling
Ensembl ID	ENSG00000105639
GeneCards	JAK3
Human Protein Atlas	JAK3
Associated Diseases	Inflammation, Ms, Neuroinflammation
Interactions	APOPTOSIS, CYTOKINES, GBM, IRF1, JAK, JAK1
KG Connections	78 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

JAK3 Gene

gene · 1443 words

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Pathway Diagram

graph TD
    JAK3["JAK3"]
    Tumor{"Tumor"}
    JAK3 -->|"regulates"| Tumor
    Ms{"Ms"}
    JAK3 -->|"expressed in"| Ms
    Stroke{"Stroke"}
    JAK3 -->|"therapeutic target"| Stroke
    Ischemia{"Ischemia"}
    JAK3 -->|"inhibits"| Ischemia
    JAK3 -->|"therapeutic target"| Ms
    JAK3 -->|"associated with"| Ms
    Neuroinflammation{"Neuroinflammation"}
    JAK3 -->|"associated with"| Neuroinflammation
    Inflammation{"Inflammation"}
    JAK3 -->|"associated with"| Inflammation
    Cardiovascular{"Cardiovascular"}
    JAK3 -->|"biomarker for"| Cardiovascular
    Atherosclerosis{"Atherosclerosis"}
    JAK3 -->|"biomarker for"| Atherosclerosis
    Diabetes{"Diabetes"}
    JAK3 -->|"biomarker for"| Diabetes
    Als{"Als"}
    JAK3 -->|"biomarker for"| Als
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"inhibits"| JAK3
    STAT3["STAT3"]
    STAT3 -->|"inhibits"| JAK3
    CD4["CD4"]
    CD4 -->|"biomarker for"| JAK3
    ZAP70["ZAP70"]
    ZAP70 -->|"biomarker for"| JAK3
    MFN1["MFN1"]
    MFN1 -->|"interacts with"| JAK3
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"biomarker for"| JAK3
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"biomarker for"| JAK3
    style JAK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
STROKE	therapeutic_target	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
APOPTOSIS	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
Tgf-Β	biomarker_for	pathway	0.60
GENES	therapeutic_target	gene	0.60
STAT3	activates	gene	0.60
TYK2	activates	gene	0.60
JAK	inhibits	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
GAIN	expressed_in	gene	0.60
STAT1	expressed_in	gene	0.60
STAT6	expressed_in	gene	0.60
JAK1	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
STAT3	expressed_in	gene	0.60
HMOX1	therapeutic_target	gene	0.60
SERPINE1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
MMP3	therapeutic_target	gene	0.60
STAT3	regulates	gene	0.60
IRF1	inhibits	gene	0.60
GBM	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
STAT3	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
STAT5A	associated_with	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
IFN	contributes_to	gene	0.60
Jak-Stat	contributes_to	pathway	0.60

Incoming (27)

Source	Relation	Type	Str
PIK3C3	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
JAK1	activates	gene	0.60
JAK2	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
HIF	regulates	gene	0.60
CD4	biomarker_for	gene	0.60
ZAP70	biomarker_for	gene	0.60
MFN1	interacts_with	gene	0.60
MMP3	therapeutic_target	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
JAK1	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
STAT2	associated_with	gene	0.60
STAT4	associated_with	gene	0.60
JAK	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
GENES	contributes_to	gene	0.60
CYTOKINES	inhibits	gene	0.60
STAT3	therapeutic_target	gene	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
STAT3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAK3 in their description or question text

No additional research found