| Gene Symbol | Serpin Family E Member 1 (PAI-1) |
| Chromosome | 7q22.1 |
| Function | is a 46 kDa glycoprotein that exists in three conformational states: active, latent, and cleaved. |
| Primary Expression | neurons, astrocytes, microglia, and endothelial cells within the brain |
| Molecular Weight | 46 kDa |
| Amino Acids | 402 aa |
| Pathways | Angiogenesis, Autophagy, Blood-Brain Barrier, Chaperone, Complement |
| UniProt ID | P05121 |
| NCBI Gene ID | 5054 |
| Ensembl ID | ENSG00000105341 |
| OMIM | 173360 |
| Synaptic Plasticity | PAI-1 modulates NMDA receptor signaling and affects long-term potentiation (LTP), with implications for memory formation. [@brown2021] |
| Neuroinflammation | Astrocyte and microglial PAI-1 production influences cytokine expression and immune cell trafficking |
| BBB Integrity | PAI-1 regulates pericyte function and endothelial-pericyte communication at the BBB. [@chen2022] |
| Neural Stem Cell Biology | The protein affects neurogenesis and neural progenitor cell migration |
| Associated Diseases | ALS, Alzheimer, Coagulopathy, Ischemia, schizophrenia |
| Known Drugs/Compounds | tiplaxtinin |
| Interactions | AGING, AKT, AND, ARSA, AUTOPHAGY, CCL2 |
| KG Connections | 186 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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