gene

COL4A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COL4A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

46Outgoing

36Incoming

0Experiments

0Debates

Summary

COL4A1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, contributes to. Associated with Aging, Als, Alzheimer. Connected to 55 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	COL4A1
Full Name	Collagen Type IV Alpha 1 Chain
Chromosome	13q34
Protein Family	Type IV collagen alpha chain family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	basement membranes:
Molecular Weight	161 kDa
Amino Acids	664 aa
Exons	52
UniProt ID	P02462
NCBI Gene ID	1282
Ensembl ID	ENSG00000187498
OMIM	120130
GeneCards	COL4A1
Human Protein Atlas	COL4A1
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Dementia
Interactions	ABCB1, APOD, APOPTOSIS, CANCER, CD44, CREBBP
KG Connections	82 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: COL4A1 — AlphaFold P02462 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COL4A1 Gene

gene · 963 words

→

COL4A1 Protein

protein · 1216 words

→

Pathway Diagram

graph TD
    COL4A1["COL4A1"]
    Dementia{"Dementia"}
    COL4A1 -->|"associated with"| Dementia
    Aging{"Aging"}
    COL4A1 -->|"associated with"| Aging
    Alzheimer{"Alzheimer"}
    COL4A1 -->|"associated with"| Alzheimer
    Als{"Als"}
    COL4A1 -->|"associated with"| Als
    Ms{"Ms"}
    COL4A1 -->|"associated with"| Ms
    COL4A1 -->|"contributes to"| Dementia
    COL4A1 -->|"contributes to"| Aging
    COL4A1 -->|"contributes to"| Als
    Stroke{"Stroke"}
    COL4A1 -->|"contributes to"| Stroke
    Carcinoma{"Carcinoma"}
    COL4A1 -->|"inhibits"| Carcinoma
    COL4A1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    COL4A1 -->|"inhibits"| Cancer
    NOTCH3["NOTCH3"]
    NOTCH3 -->|"contributes to"| COL4A1
    GENES["GENES"]
    GENES -->|"contributes to"| COL4A1
    HTRA1["HTRA1"]
    HTRA1 -->|"contributes to"| COL4A1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| COL4A1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| COL4A1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| COL4A1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| COL4A1
    TNC["TNC"]
    TNC -->|"inhibits"| COL4A1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| COL4A1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| COL4A1
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| COL4A1
    LZTS1["LZTS1"]
    LZTS1 -->|"associated with"| COL4A1
    style COL4A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Aging	associated_with	disease	0.75
Ms	associated_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	contributes_to	disease	0.65
PDHX	associated_with	gene	0.60
SLC16A2	associated_with	gene	0.60
GNAO1	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
PDGFRB	activates	gene	0.60
SLC6A1	activates	gene	0.60
pericytes	expressed_in	cell_type	0.60
Notch	contributes_to	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
Complement	associated_with	pathway	0.60
AND	associated_with	gene	0.60
Epithelial	activates	cell_type	0.60
CREBBP	interacts_with	gene	0.60
Fibroblast	activates	cell_type	0.60
LZTS1	associated_with	gene	0.60
APOC2	associated_with	gene	0.60
SATB2	associated_with	gene	0.60
ATL1	associated_with	gene	0.60
OVERVIEW	contributes_to	gene	0.60
lipid metabolism	participates_in	pathway	0.60
Mapk	interacts_with	pathway	0.60
INSR	activates	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
SPAST	associated_with	gene	0.60
SERPINE1	interacts_with	gene	0.60
Transferrin	activates	protein	0.60
Rb	associated_with	protein	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	associated_with	pathway	0.60
POLR2A	associated_with	gene	0.60
SLC16A2	co_mentioned	gene	0.40

Incoming (36)

Source	Relation	Type	Str
STING	upregulates	protein	0.88
AGING	associated_with	gene	0.70
APOD	activates	gene	0.60
NOTCH3	contributes_to	gene	0.60
HTRA1	contributes_to	gene	0.60
TNF	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
RNA	interacts_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	associated_with	gene	0.60
LZTS1	associated_with	gene	0.60
DCC	associated_with	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	associated_with	gene	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60
RGS1	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
APOC2	associated_with	gene	0.60
SPAST	associated_with	gene	0.60
SMAD3	activates	gene	0.60
ATL1	associated_with	gene	0.60
ABCB1	activates	gene	0.60
IL-6	associated_with	gene	0.60
TNF-Α	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COL4A1 in their description or question text

No additional research found