gene

arsa

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arsa: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

20Outgoing

8Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARSA
Full Name	Arylsulfatase A
Chromosome	22q13.33
Protein Type	Enzyme
Function	ARSA is a lysosomal hydrolase (517 amino acids, 54 kDa) that catalyzes desulfation of cerebroside 3-sulfate (sulfatide) within myelin sheaths.
Primary Expression	white matter regions rich in myelin
Molecular Weight	54 kDa
Amino Acids	517 aa
Exons	8
UniProt ID	P15289
NCBI Gene ID	25
Ensembl ID	ENSG00000166295
OMIM	607574
GeneCards	ARSA
Human Protein Atlas	ARSA
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: arsa — AlphaFold P15289 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARSA Gene

gene · 1032 words

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Pathway Diagram

graph TD
    ARSA["ARSA"]
    ARSA -->|"activates"| Aging["Aging"]
    ARSA -->|"activates"| Melanoma["Melanoma"]
    ARSA -.biomarker for.-> Senescence["Senescence"]
    ARSA -->|"contributes to"| MYELIN["MYELIN"]
    ARSA -->|"contributes to"| PSAP["PSAP"]
    ARSA -->|"contributes to"| AUTOPHAGY["AUTOPHAGY"]
    ARSA -->|"contributes to"| Autophagy["Autophagy"]
    ARSA -->|"contributes to"| Sphingolipid["Sphingolipid"]
    CCL3["CCL3"] -->|"activates"| ARSA
    RAB27A["RAB27A"] -->|"activates"| ARSA
    AND["AND"] -.biomarker for.-> ARSA
    CYTOKINES["CYTOKINES"] -->|"activates"| ARSA
    SERPINE1["SERPINE1"] -->|"activates"| ARSA
    AGING["AGING"] -->|"activates"| ARSA
    LAMP1["LAMP1"] -->|"activates"| ARSA

Outgoing (20)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARSA	data_in	dataset_row	0.00
Senescence	biomarker_for	disease	0.65
Aging	activates	disease	0.65
Melanoma	activates	disease	0.65
Lipid Metabolism	contributes_to	pathway	0.60
CCL2	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Exocytosis	activates	pathway	0.60
Chaperone	activates	pathway	0.60
Autophagy	activates	pathway	0.60
GLA	associated_with	gene	0.60
GALC	associated_with	gene	0.60
PSAP	contributes_to	gene	0.60
LAMP2	activates	gene	0.60
CXCL12	activates	gene	0.60
MYELIN	contributes_to	gene	0.60
CTSD	activates	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
Autophagy	contributes_to	pathway	0.60
Sphingolipid	contributes_to	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARSA	data_in	dataset_row	0.00
RAB27A	activates	gene	0.60
SERPINE1	activates	gene	0.60
LAMP1	activates	gene	0.60
CCL3	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AGING	activates	gene	0.60
AND	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arsa in their description or question text

No additional research found