disease

BREAST CANCER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BREAST CANCER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1093Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Disease Info

Associated Genes	AKT, AKT1, ARID1A, MCOLN1, PIK3CA, PRMT5, PTEN, RHOT1
Therapeutic Agents	CISPLATIN
KG Connections	291 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| CELL_PROLIFERATION["CELL PROLIFERATION"]
    style CELL_PROLIFERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| CDK4["CDK4"]
    style CDK4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| LONG_NON_CODING_RNA["LONG NON-CODING RNA"]
    style LONG_NON_CODING_RNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    style ENDOTHELIAL_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CTDNA["CTDNA"] -->|"biomarker for"| BREAST_CANCER["BREAST CANCER"]
    style CTDNA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FERROPTOSIS_1["FERROPTOSIS"] -->|"associated"| BREAST_CANCER["BREAST CANCER"]
    style FERROPTOSIS_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    METASTASIS["METASTASIS"] -->|"regulates"| BREAST_CANCER["BREAST CANCER"]
    style METASTASIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT_2["AKT"] -->|"causes"| BREAST_CANCER["BREAST CANCER"]
    style AKT_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APP["APP"] -.->|"inhibits"| BREAST_CANCER["BREAST CANCER"]
    style APP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style BREAST_CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (382)

Target	Relation	Type	Str
Cancer	regulates	disease	1.00
Cancer	associated_with	disease	1.00
Metastasis	therapeutic_target	pathway	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
Als	inhibits	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Metastasis	activates	pathway	1.00
Cancer	activates	disease	1.00
Cancer	causes	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	treats	pathway	1.00
Apoptosis	activates	pathway	1.00
Als	treats	disease	1.00
Cancer	treats	disease	1.00
Als	activates	disease	1.00
Metastasis	treats	pathway	1.00
Invasion	inhibits	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Mtor	inhibits	pathway	1.00
Metastasis	associated_with	pathway	1.00
Immune Checkpoint	inhibits	pathway	1.00
White Population	associated_with	phenotype	0.95
Carcinoma	associated_with	disease	0.95
Cancer	expressed_in	disease	0.95
Epithelial-Mesenchymal Transition	inhibits	pathway	0.90
Nf-Κb	therapeutic_target	pathway	0.90
Pi3K/Akt	inhibits	pathway	0.90
Angiogenesis	therapeutic_target	pathway	0.90
Mtor	treats	pathway	0.90
Pi3K/Akt	treats	pathway	0.90
Apoptosis	associated_with	pathway	0.90
Mitophagy	activates	pathway	0.90
Stem Cell	inhibits	pathway	0.90
Metastasis	inhibits	pathway	0.90
Als	biomarker_for	disease	0.85
Metastasis	causes	pathway	0.80
Metastasis	expressed_in	pathway	0.80
Invasion	activates	pathway	0.80
Epigenetic	inhibits	pathway	0.80
Immune Checkpoint	therapeutic_target	pathway	0.80
Autophagy	inhibits	pathway	0.80
Checkpoint Inhibitor	inhibits	pathway	0.80
Invasion	expressed_in	pathway	0.80
Glycolysis	activates	pathway	0.80
Er Stress	activates	pathway	0.80

Incoming (711)

Source	Relation	Type	Str
Tumor	inhibits	disease	1.00
DNA	inhibits	gene	1.00
EGFR	therapeutic_target	gene	1.00
Cancer	activates	disease	1.00
AKT	activates	gene	1.00
AKT	treats	gene	1.00
PI3K	therapeutic_target	gene	1.00
CANCER	regulates	gene	1.00
CANCER	causes	gene	1.00
MTOR	therapeutic_target	gene	1.00
Tumor	regulates	disease	1.00
STAT3	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	inhibits	gene	1.00
MTOR	inhibits	gene	1.00
PI3K	inhibits	gene	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	inhibits	gene	1.00
CANCER	expressed_in	gene	1.00
AKT	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	treats	disease	1.00
CANCER	treats	gene	1.00
PTEN	therapeutic_target	gene	1.00
Tumor	activates	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
APOPTOSIS	treats	gene	1.00
PI3K	treats	gene	1.00
GENES	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
MIRNAS	associated_with	gene	1.00
Als	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
Tumor	associated_with	disease	1.00
MITOCHONDRIA	activates	gene	1.00
GENES	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
ERBB2	associated_with	gene	0.98
HER2	associated_with	protein	0.98
Obesity	risk_factor_for	phenotype	0.95
Pi3K/Akt/Mtor Pathway	involved_in	pathway	0.95
PI3K/AKT/mTOR	involved_in	pathway	0.95
Glutathione/Scarb2/Mtor Axis	contributes_to	pathway	0.95
MTOR	associated_with	protein	0.95
MYC	activates	gene	0.95
HER2 overexpression	risk_factor_for	phenotype	0.95
PI3K	associated_with	protein	0.95
Hu-Loaded Exosomes	inhibits	compound	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BREAST CANCER in their description or question text

No additional research found