RHOT1

RHOT1 Protein

Score: 0.337 Price: $0.34 Undruggable Druggability Status: active Wiki: RHOT1 - Mitochondrial Rho GTPase 1

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 RHOT1 — PDB 4I5R Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q8IXI2

🧬 3D Protein Structure

🧬 RHOT1 — PDB 4I5R Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for Q8IXI2

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Linked Hypotheses (1)

Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy0.549

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

interacts with (20)

CAT→RHOT1OPTN→RHOT1DNM1L→RHOT1CANX→RHOT1LGALS3→RHOT1

▸ Show 15 more

CALCOCO2→RHOT1G3BP1→RHOT1PEX3→RHOT1SQSTM1→RHOT1BCL2→RHOT1LMNA→RHOT1STING1→RHOT1TAX1BP1→RHOT1ATM→RHOT1SNCAIP→RHOT1RB1CC1→RHOT1MFN1→RHOT1ERN1→RHOT1PARKIN→RHOT1FMR1→RHOT1

Debate History (1)

Should RHOT1 (RHOT1 Protein) be prioritized as a therapeutic target for neurodeg2026-04-26