Contents

RHOT1 Protein - MIRO1 - Mitochondrial Rho GTPase 1

🔬 Protein Info

Gene Symbol	RHOT1
Aliases	Page for RHOT1, Page for RHOT1 Protein
Target Class	Protein
Function	Calcium-Dependent GTPase Activity: - MIRO1 hydrolyzes GTP to GDP, regulated by calcium binding to EF-hand domains - Calcium influx through NMDA receptors or voltage-gated calcium channels activates MI
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Subcellular Localization	</th><td>Outer mitochondrial membrane (OMM)</td></tr>
Druggability	Undruggable (0.23)
Molecular Weight	71.4 kDa
Amino Acids	618 aa
Pathways	mitochondrial homeostasis
Ensembl ID	ENSG00000153823
GeneCards	RHOT1
Human Protein Atlas	RHOT1
Associated Diseases	AD, ALI, Als, Alzheimer, BREAST CANCER
Known Drugs/Compounds	Electroacupuncture
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
SciDEX Target	View Target Profile
SciDEX Hypotheses	Miro1-Mediated Mitochondrial Trafficking Enhanceme
KG Connections	719 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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