protein

MBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

441Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MBP is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, inhibits. Associated with ALS, Aging, Als. Connected to 174 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	MBP
Full Name	Myelin Basic Protein
Chromosome	18q23
Function	Membrane compaction: MBP interacts with the cytoplasmic surface of the oligodendrocyte membrane, facilitating the tight apposition of myelin lamellae [6]
Primary Expression	a developmentally regulated manner, with different isoforms predominant at different stages of oligodendrocyte maturation and myelination
Subcellular Localization	and interaction with other myelin proteins. The 18.5 kDa isoform is the most abundant in adult human brain and is the pr
Molecular Weight	21.5 kDa
Amino Acids	197 aa
Exons	11
Pathways	MAPK
Ensembl ID	ENSG00000197971
GeneCards	MBP
Human Protein Atlas	MBP
Signal transduction	MBP can be phosphorylated, suggesting roles in cell signaling
Calcium homeostasis	MBP influences calcium signaling in oligodendrocytes
Associated Diseases	Als, Alzheimer, Alzheimer disease, dementia, Ms
Known Drugs/Compounds	metformin
Interactions	ACHE, ACSL4, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Myelin Breakdown-Amyloid Interaction Amplifies Cor
KG Connections	440 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MBP["MBP"]
    MBP -->|"activates"| Dementia["Dementia"]
    MBP -->|"activates"| Als["Als"]
    MBP -->|"activates"| Alzheimer["Alzheimer"]
    MBP -->|"activates"| Parkinson["Parkinson"]
    MBP -->|"activates"| Ms["Ms"]
    MBP -->|"activates"| Inflammation["Inflammation"]
    MBP -->|"regulates"| Stroke["Stroke"]
    MBP -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    MBP -->|"regulates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    HSPA1A["HSPA1A"] -->|"activates"| MBP
    GFAP["GFAP"] -->|"inhibits"| MBP
    GAP43["GAP43"] -->|"inhibits"| MBP
    ELAVL3["ELAVL3"] -->|"inhibits"| MBP
    MANF["MANF"] -->|"inhibits"| MBP
    P38["P38"] -->|"regulates"| MBP
    CD36["CD36"] -->|"activates"| MBP
    TNF["TNF"] -->|"regulates"| MBP
    ACHE["ACHE"] -->|"activates"| MBP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| MBP

Outgoing (275)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Myelin Degeneration	biomarker_for	phenotype	0.87
Als	expressed_in	disease	0.85
Microglia	upregulates	cell_type	0.85
Hypermyelination	involved_in	phenotype	0.85
Inflammation	activates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
oligodendrocytes	expressed_in	cell_type	0.80
Parkinson's Disease Dementia	upregulates	disease	0.80
MICROGLIA	inhibits	cell_type	0.70
PINK1	activates	gene	0.70
SQSTM1	activates	gene	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
MOG	stabilizes	gene	0.70
MICROGLIA	degrades	cell_type	0.70
SOD2	activates	gene	0.70
SYN1	stabilizes	gene	0.70
Apoptosis	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
MICROGLIA	activates	cell_type	0.70
Autophagy	expressed_in	pathway	0.70
AUTOPHAGY	expressed_in	gene	0.70
Tumor	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Stroke	regulates	disease	0.65
OLIGODENDROCYTE	associated_with	concept	0.65
MTOR	co_discussed	gene	0.65
Multiple Sclerosis	contributes_to	disease	0.65
MOG	associated_with	gene	0.65
OLIG2	co_discussed	gene	0.65
PLP1	associated_with	gene	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (166)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Bpmc	downregulates	compound	0.85
Transcranial near-infrared light	upregulates	compound	0.85
BPMC	downregulates	gene	0.85
OLEA	upregulates	compound	0.80
MYELIN	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
BIN1	biomarker_for	gene	0.70
LAMP1	associated_with	gene	0.70
BDNF	inhibits	gene	0.70
BECN1	activates	gene	0.70
CNP	activates	gene	0.70
ATG5	activates	gene	0.70
ATG7	activates	gene	0.70
CAT	activates	gene	0.70
TNF	activates	gene	0.70
GENES	activates	gene	0.70
OLIGODENDROCYTE	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
APOE	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
CLU	co_discussed	gene	0.65
BIN1	co_discussed	gene	0.65
DEMYELINATION	regulates	phenotype	0.65
P38	regulates	gene	0.60
CD36	activates	gene	0.60
TNF	regulates	gene	0.60
MMP9	associated_with	gene	0.60
RELA	expressed_in	gene	0.60
OPA1	associated_with	gene	0.60
P62	expressed_in	gene	0.60
MFN2	associated_with	gene	0.60
BAX	activates	gene	0.60
AND	inhibits	gene	0.60
AMPK	activates	gene	0.60
metformin	targets	drug	0.60
AUTOPHAGY	activates	pathway	0.60
BCL2	activates	gene	0.60
ROS	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
IL-6	expressed_in	gene	0.60
SYN2A	inhibits	gene	0.60
STROKE	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
TUBULIN	inhibits	gene	0.60
RAC1	activates	gene	0.60
GFAP	activates	gene	0.60
F3	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Myelin Breakdown-Amyloid Interaction Amplifies Cortical Agin	0.600	Alzheimer disease	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (1)

Scientific analyses that reference this entity

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does gene expression change across age groups (young/middle/old) in hippocam

active · Rounds: 4 · Score: 1.00 · 2026-04-24

Related Research

Hypotheses and analyses mentioning MBP in their description or question text

No additional research found

MBP