concept

METFORMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METFORMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

580Connections

1Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	METFORMIN
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	ACETYLCHOLINE, aging, AGING, ALS, ALZHEIMER
Related Pathways	AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Metformin for Parkinson's Disease - Phase 2/3 Trial (NCT07229651)

clinical · 1298 words

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Pathway Diagram

graph TD
    METFORMIN["METFORMIN"]
    style METFORMIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    METFORMIN -->|"upregulates"| SIRT1([SIRT1])
    METFORMIN -->|"treats"| Hepatic_Steatosis["Hepatic Steatosis"]
    METFORMIN -->|"activates"| SIRT1_Mediated_Autophagy["SIRT1-Mediated Autophagy"]
    METFORMIN -->|"treats"| Cognitive_Impairment(Cognitive Impairment)
    METFORMIN -->|"activates"| AMPK([AMPK])
    METFORMIN -.->|"inhibits"| astrocyte_senescence["astrocyte senescence"]
    METFORMIN -->|"modulates"| Mitochondrial_Biogenesis["Mitochondrial Biogenesis"]
    METFORMIN -->|"modulates"| Mitochondrial_Dynamics["Mitochondrial Dynamics"]
    METFORMIN -.->|"protects against"| Hippocampal_Neurodegeneration["Hippocampal Neurodegeneration"]

Outgoing (382)

Target	Relation	Type	Str
Necroptosis	suppresses	process	0.95
astrocyte senescence	inhibits	process	0.95
PRKAA1	activates	gene	0.95
Mitochondrial Respiratory Activity	associated_with	process	0.95
SIRT1	upregulates	gene	0.95
Hepatic Steatosis	treats	disease	0.95
Ribociclib-Induced Toxicity	treats	phenotype	0.95
SIRT1-Mediated Autophagy	activates	pathway	0.95
Mitochondrial Bioenergetics	associated_with	process	0.95
Redox Homeostasis	associated_with	process	0.95
Autophagy	associated_with	process	0.95
Cognitive Impairment	treats	phenotype	0.95
AMPK	activates	protein	0.95
Cadmium Neurotoxicity	treats	disease	0.93
Pro-Inflammatory Pathways	associated_with	pathway	0.92
pro-inflammatory pathways	associated_with	pathway	0.90
Immune-Inflammatory Responses	modulates	process	0.90
Type 2 Diabetes	treats	disease	0.90
Insulin Resistance	treats	disease	0.90
Cognitive Impairment	protects_against	phenotype	0.90
oxidative stress	associated_with	process	0.90
insulin sensitivity	treats	phenotype	0.90
mitochondrial function	regulates	process	0.90
Glucose Homeostasis	associated_with	phenotype	0.90
Glucose Homeostasis	regulates	process	0.90
therapeutic CNS concentrations	associated_with	phenotype	0.90
PRKAA1/2	activates	gene	0.90
Hyperglycemia	treats	disease	0.90
MCOLN1	downregulates	gene	0.90
Pruritus	treats	phenotype	0.90
Hippocampal Neurodegeneration	protects_against	process	0.90
Mitochondrial Dynamics	modulates	process	0.90
Type 2 Diabetes	treats	disease	0.90
Mitochondrial Biogenesis	modulates	process	0.90
MCOLN1	suppresses	gene	0.90
KRTAP	upregulates	gene	0.90
Insulin Resistance	associated_with	phenotype	0.90
KRTAPS	upregulates	gene	0.88
dopamine neuron injury	prevents	phenotype	0.88
Neuroinflammation	modulates	process	0.88
Mitochondrial Function	modulates	process	0.88
RIPK1	inhibits	gene	0.88
Oxidative Stress	associated_with	phenotype	0.87
ATP Levels	associated_with	biomarker	0.85
Membrane Potential	associated_with	phenotype	0.85
Parkinson's Disease	treats	disease	0.85
Neurodegeneration	protects_against	disease	0.85
PRKAA2	activates	gene	0.85
Central Centrifugal Cicatricial Alopecia	treats	disease	0.85
MMP7	downregulates	gene	0.85

Incoming (198)

Source	Relation	Type	Str
P_glycoprotein	associated_with	protein	0.90
PRKAA2	therapeutic_target	gene	0.90
PRKAA1	therapeutic_target	gene	0.90
AMPK	targets	gene	0.70
BDNF	associated_with	gene	0.65
SYK	regulates	gene	0.65
PARKINSON'S DISEASE	targets	disease	0.65
HEPATOCYTES	treats	cell_type	0.65
CCL2	inhibits	gene	0.65
AKT	regulates	gene	0.65
TREM2	protects_against	gene	0.65
AMPK	treats	gene	0.65
ENDOTHELIAL	causes	cell_type	0.65
CA1	protects_against	brain_region	0.65
GFAP	protects_against	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
NICOTINAMIDE	activates	drug	0.65
NICOTINAMIDE	treats	drug	0.65
MLKL	inhibits	gene	0.65
MLKL	activates	gene	0.65
NEURONS	treats	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
TNF	inhibits	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
CGAS	mediates	gene	0.65
TH	causes	gene	0.65
AMYLOID PLAQUES	protects_against	phenotype	0.65
DIABETES	associated_with	disease	0.65
DIABETES	targets	disease	0.65
AMPK	associated_with	gene	0.55
AMPK	participates_in	gene	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
Autophagy	decreases_risk	process	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
NEUROBLASTOMA	associated_with	disease	0.50
LUNG CANCER	associated_with	disease	0.50
NEURODEGENERATIVE DISORDERS	decreases_risk	concept	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
ENDOTHELIAL	decreases_risk	concept	0.50
SIRT1	decreases_risk	gene	0.50
AMPK	activates	gene	0.50
aging	associated_with	phenotype	0.50
aging	protects_against	phenotype	0.50
aging	inhibits	phenotype	0.50
CLOCK	associated_with	gene	0.50
T CELL	inhibits	cell_type	0.50
CHOLESTEROL	associated_with	phenotype	0.50