concept

OLIGODENDROCYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1820Connections

22Hypotheses

1Analyses

50Outgoing

50Incoming

8Experiments

1Debates

Summary

OLIGODENDROCYTE is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 369 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTE
Key Genes/Proteins	AB, ABCA1, ACHE, ACTB, AD, ADAM10
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oligodendrocyte Lineage in Multiple System Atrophy

cell · 675 words

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Pathway Diagram

graph TD
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
    OLIGODENDROCYTE -->|"regulates"| Myelin["Myelin"]
    OLIGODENDROCYTE -->|"regulates"| Aging["Aging"]
    OLIGODENDROCYTE -->|"activates"| Inflammation["Inflammation"]
    OLIGODENDROCYTE -->|"inhibits"| ALS["ALS"]
    OLIGODENDROCYTE -->|"inhibits"| Autoimmune["Autoimmune"]
    OLIGODENDROCYTE -->|"inhibits"| GPR37["GPR37"]
    OLIGODENDROCYTE -->|"inhibits"| Myelination["Myelination"]
    OLIGODENDROCYTE -->|"activates"| INFLAMMATION["INFLAMMATION"]
    MLKL["MLKL"] -->|"activates"| OLIGODENDROCYTE
    OPTN["OPTN"] -.protects against.-> OLIGODENDROCYTE
    AQUAPORIN_4["AQUAPORIN-4"] -.biomarker for.-> OLIGODENDROCYTE
    MYELIN["MYELIN"] -.biomarker for.-> OLIGODENDROCYTE
    MOG["MOG"] -.biomarker for.-> OLIGODENDROCYTE
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| OLIGODENDROCYTE
    BANG["BANG"] -->|"activates"| OLIGODENDROCYTE
    COMPLEMENT["COMPLEMENT"] -->|"causes"| OLIGODENDROCYTE
    AQP4["AQP4"] -->|"causes"| OLIGODENDROCYTE

Outgoing (692)

Target	Relation	Type	Str
Myelin Degeneration	contributes_to	phenotype	0.95
Alzheimer'S Disease	involved_in	disease	0.95
Myelin	associated_with	structure	0.95
Active Lesion Rim	involved_in	phenotype	0.90
Remyelination	involved_in	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
neurodegeneration	drives	process	0.90
Neuroinflammation	associated_with	process	0.90
Neurodegeneration	associated_with	process	0.90
neuroinflammation	drives	process	0.90
Neuroinflammation	mediates	process	0.90
Excitotoxicity	mediates	process	0.90
MICROGLIA	activates	gene	0.90
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Als	activates	disease	0.85
Axonal Myelination	involved_in	process	0.85
Multiple Sclerosis	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Multiple Sclerosis	associated_with	disease	0.85
Inflammatory Genes	upregulates	process	0.80
MYELIN	associated_with	gene	0.80
ASTROCYTE	activates	gene	0.80
Autoimmune	inhibits	disease	0.75
Autoimmune	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Alzheimer's disease	implicated_in	disease	0.75
Alzheimer	inhibits	disease	0.75
Dementia	inhibits	disease	0.75
Stroke	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
P2RX7	expresses	gene	0.70
PERICYTE	disrupts	cell_type	0.70
PERICYTES	disrupts	cell_type	0.70
TAU	causes	gene	0.70
PERICYTES	inhibits	cell_type	0.70
TREM2	regulates	gene	0.70
STING	disrupts	gene	0.70
STING	associated_with	gene	0.70
RAGE	markers	gene	0.70
OLIGODENDROCYTES	enhances	cell_type	0.70
STING	expresses	gene	0.70
OLIGODENDROCYTES	degrades	cell_type	0.70
TAU	expresses	gene	0.70
P2RX7	inhibits	gene	0.70
PERICYTE	inhibits	cell_type	0.70
OLIGODENDROCYTES	expresses	cell_type	0.70
ULK1	activates	gene	0.70
TFEB	targets	gene	0.70

Incoming (1128)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	1.00
MICROGLIA	associated_with	gene	0.98
ASTROCYTES	associated_with	gene	0.98
ALZHEIMER'S DISEASE	associated_with	gene	0.90
Ferroptosis	expressed_in	process	0.90
Multiple Sclerosis	downregulates	disease	0.90
Multiple Sclerosis	causes	disease	0.90
COMPLEMENT CASCADE	causes	entity	0.90
MYELIN	activates	gene	0.90
IGF1	promotes	protein	0.88
APOE4	expressed_in	gene	0.88
Microglia	interacts_with	cell_type	0.85
Cholesterol Metabolism	expressed_in	pathway	0.85
Α-SYNUCLEIN	expressed_in	protein	0.80
MYELIN	associated_with	gene	0.75
OPC	associated_with	cell_type	0.75
SERPINA3N	expressed_in	gene	0.75
NEUROINFLAMMATION	associated_with	gene	0.74
TAU	associated_with	protein	0.74
BIN1	regulates	gene	0.70
BACE1	expresses	gene	0.70
BACE1	inhibits	gene	0.70
BACE1	disrupts	gene	0.70
MICROGLIA	targets	cell_type	0.70
BACE1	causes	gene	0.70
NEURONS	targets	cell_type	0.70
GABAERGIC	causes	cell_type	0.70
ABCA1	associated_with	gene	0.70
GLUTAMATERGIC	regulates	cell_type	0.70
MULTIPLE SCLEROSIS	transports	disease	0.70
NEURONS	causes	cell_type	0.70
MULTIPLE SCLEROSIS	expresses	disease	0.70
GABAERGIC	regulates	cell_type	0.70
ABCA1	expresses	gene	0.70
MOTOR NEURON	expresses	cell_type	0.70
BECN1	activates	gene	0.70
GRN	markers	gene	0.70
MOTOR NEURON	associated_with	cell_type	0.70
MAPT	associated_with	gene	0.70
NEURONS	markers	cell_type	0.70
MACROPHAGE	expresses	cell_type	0.70
BECN1	interacts_with	gene	0.70
GFAP	activates	gene	0.70
CNP	regulates	gene	0.70
APOE	inhibits	gene	0.70
MOTOR NEURON	causes	cell_type	0.70
FOXP3	activates	gene	0.70
BECN1	expresses	gene	0.70
MICROGLIA	transports	cell_type	0.70
AIF1	expresses	gene	0.70

Targeting Hypotheses (22)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.806	neuroinflammation	How do oligodendrocytes initiate neuroin
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Oligodendrocyte Precursor Cell Senescence in White Matter Di	0.769	-	Senescent cell clearance as neurodegener

PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.734	neuroinflammation	How do oligodendrocytes initiate neuroin
TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy	0.691	neuroscience	Circuit-level neural dynamics in neurode
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution	0.680	neurodegeneration	Neuroinflammation resolution mechanisms
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.667	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte DNA Repair Enhancement Therapy	0.665	neurodegeneration	Cell type vulnerability in Alzheimer's D
Oligodendrocyte White Matter Vulnerability	0.651	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling	0.649	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte Remyelination Enhancement	0.644	neurodegeneration	Gene expression changes in aging mouse b
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.620	neurodegeneration	Cell type vulnerability in Alzheimer's D
TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White	0.600	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therap	0.599	neurodegeneration	Which cell types show the most significa
TREM2-Mediated Oligodendrocyte-Microglia Signaling in White	0.587	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte Progenitor Cell Metabolic Reprogramming	0.575	neurodegeneration	Which cell types show the most significa
AQP4 Autoantibodies in NMOSD Cause Bystander Oligodendrocyte	0.560	neurodegeneration	What are the specific molecular mechanis
Oligodendrocyte DNA Repair Enhancement	0.550	neurodegeneration	Cell type vulnerability in Alzheimers Di
Oligodendrocyte Lineage Vulnerability: Early Myelination Dis	0.530	neurodegeneration	Cell type vulnerability debate in Alzhei

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	0.00	human patients undergoing thor	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
Molecular docking analysis of aminophylline binding targets	exploratory	depression	0.800	0.00	in silico molecular docking	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	0.00	endocycling mammalian cells	proposed	N/A
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Role and regulatory mechanism of GPR37 in neurological diseases. [PMID:40822851]	Liu S, Bai T, Liu X, Zhao W, Li X, Sui Y	Front Cell Neurosci	2025	1
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287]	Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J	Cell Rep	2025	1
Inflammation and Infection in Pain and the Role of GPR37. [PMID:36430912]	Zhang Q, Bang S, Chandra S, Ji RR	Int J Mol Sci	2022	1
Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 [PMID:34678058]	Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang	Sci Adv	2021	1
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. [PMID:30010619]	Bang S, Xie YK, Zhang ZJ, Wang Z, Xu ZZ,	J Clin Invest	2018	1
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026	0
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026	0
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026	0
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026	0
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026	0
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026	0
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026	0
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026	0
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026	0
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026	0
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026	0
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026	0
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026	0
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03