gene

BIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

998Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Bridging Integrator 1 (BIN1) is the second strongest genetic risk factor for late-onset Alzheimer's disease after APOE4. BIN1 encodes a BAR domain protein involved in membrane dynamics, endocytosis, and cytoskeletal regulation. In neurons, BIN1 modulates tau propagation by regulating endosomal trafficking and tau release via extracellular vesicles. BIN1 also interacts with clathrin and AP-2 to control synaptic vesicle recycling. AD-associated BIN1 variants increase tau pathology spreading and reduce synaptic function. BIN1 is expressed in both neurons and oligodendrocytes, with cell-type-specific roles in disease. BIN1 represents a promising therapeutic target for slowing tau propagation.

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🧬 Gene Info

Gene Symbol	BIN1
Full Name	Bridging Integrator 1
Chromosome	2q14.3
Function	is a gene located on chromosome 2q14.
Primary Expression	Cerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight	70 kDa
Exons	20
Pathways	Autophagy, Complement, Endocytosis, proinflammatory activation
UniProt ID	O00499
NCBI Gene ID	274
Ensembl ID	ENSG00000136717
OMIM	601248
GeneCards	BIN1
Human Protein Atlas	BIN1
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Interactions	ABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
KG Connections	998 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BIN1 — AlphaFold O00499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BIN1["BIN1"]
    BIN1 -->|"regulates"| phosphorylated_tau["phosphorylated tau"]
    BIN1 -->|"expressed in"| Cancer["Cancer"]
    BIN1 -->|"expressed in"| Tumor["Tumor"]
    BIN1 -->|"expressed in"| Alzheimer["Alzheimer"]
    BIN1 -->|"activates"| Als["Als"]
    BIN1 -->|"expressed in"| Senescence["Senescence"]
    BIN1 -->|"expressed in"| Ms["Ms"]
    BIN1 -->|"activates"| Inflammation["Inflammation"]
    BIN1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CD8["CD8"] -->|"expressed in"| BIN1
    STAT1["STAT1"] -->|"activates"| BIN1

Outgoing (732)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
extracellular_vesicle_trafficking	controls	pathway	0.00
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Late-Onset Alzheimer'S Disease	risk_factor_for	disease	0.95
Proinflammatory Activation	regulates	process	0.95
Alzheimer's disease	associated_with	disease	0.95
Sporadic Alzheimer's Disease	downregulates	disease	0.95
Neurodegeneration-Related Activation	regulates	process	0.95
Late-Onset Alzheimer's Disease	risk_factor_for	disease	0.95
cellular clearance	mediates	process	0.90
Endolysosomal Dysfunction	associated_with	mechanism	0.90
Cellular Clearance Mechanisms	regulates	process	0.90
tau tangles	associated_with	biomarker	0.90
Tau Pathology Propagation	inhibits	process	0.90
Amyloid-Beta Processing	regulates	mechanism	0.90
Alternate Splicing	involved_in	process	0.90
AUTOPHAGY	mediates	process	0.90
endolysosomal trafficking	mediates	pathway	0.90
trafficking	regulates	process	0.90
Tau Tangles	associated_with	biomarker	0.88
Amyloid-Beta Plaques	associated_with	biomarker	0.88
tau pathology	associated_with	phenotype	0.88
autophagy	regulates	process	0.85
cellular clearance	modulates	process	0.85
Endocytosis	associated_with	process	0.85
Synaptic Transmission	modulates	process	0.85
Endocytic Flux	inhibits	process	0.85
cytoskeletal dynamics	regulates	process	0.85
Tau Pathology	modulates	process	0.85
synaptic function	regulates	process	0.85
TAU	associated_with	protein	0.85
Ptau	associated_with	biomarker	0.85
Membrane Dynamics	regulates	process	0.85
amyloid-beta plaques	involved_in	biomarker	0.85
CR1	associated_with	gene	0.82
Frontal Cortex	expressed_in	cell_type	0.80
cellular homeostasis	associated_with	process	0.80
oxidative stress response	participates_in	pathway	0.80
Extracellular Tau Seed Uptake	inhibits	process	0.80
amyloid-beta processing	modulates	process	0.80
Neurons	expressed_in	cell_type	0.80
Oligodendrocytes	expressed_in	cell_type	0.80
BDNF/TrkB signaling	inhibits	pathway	0.80
oligodendrocytes	expressed_in	cell_type	0.80
neuroinflammation	associated_with	process	0.75

Incoming (266)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BIN1	data_in	dataset_row	0.00
ad_genetic_risk_loci:BIN1	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
APOE	associated_with	gene	0.98
AMYLOID	associated_with	gene	0.90
Tau fragment N368	interacts_with	protein	0.80
AMPH1	interacts_with	protein	0.80
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
APP	expressed_in	gene	0.70
BACE1	expressed_in	gene	0.70
APOE	expresses	gene	0.70
APOE	protects_against	gene	0.70
AMPK	activates	gene	0.70
APOE	biomarker_for	gene	0.70
ACHE	markers	gene	0.70
ARRB2	causes	gene	0.70
NEUROINFLAMMATION	associated_with	phenotype	0.65
NEURODEGENERATION	inhibits	disease	0.65
HIF1A	degrades	gene	0.65
HIF1A	regulates	gene	0.65
OLIGODENDROCYTE	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
EPILEPSY	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
AD RISK GENES	regulates	gene	0.60
GENETIC LOCI	associated_with	gene	0.60
EXOSOMES	transports	gene	0.60
MIRNAS	associated_with	gene	0.60
ALZHEIMER'S	associated_with	disease	0.60
BDNF	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
ENDOSOME	regulates	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
GENES	activates	gene	0.60
AGING	activates	gene	0.60
ABCA1	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
APP	associated_with	gene	0.60
ADAM10	interacts_with	gene	0.60
ADAMTS4	interacts_with	gene	0.60
APOC1	associated_with	gene	0.60
ALZHEIMER	co_discussed	gene	0.60
GMNC	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BIN1-dependent trafficking defects determine whether post-Aβ	0.460	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning BIN1 in their description or question text

No additional research found

BIN1

Understanding Entity Pages

Summary

Wiki Pages (5)

BIN1 — Bridging Integrator 1

ABIN1 (TNIP1) Gene

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

ABIN1 Protein

BIN1 Protein

Pathway Diagram

Outgoing (732)

Incoming (266)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (2)

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research