concept

OLIGODENDROCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1079Connections

4Hypotheses

3Analyses

50Outgoing

50Incoming

4Experiments

9Debates

Summary

OLIGODENDROCYTES is a concept in neurodegeneration research. Key relationships include: co discussed, expressed in, activates. Associated with CANCER, DEMENTIA, NEURODEGENERATION. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTES
Key Genes/Proteins	ABCA1, ACHE, AD, ADAM10, ALS, ALZHEIMER
Related Diseases	Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Oligodendrocytes

cell · 4838 words

Pathway Diagram

graph TD
    OLIGODENDROCYTES["OLIGODENDROCYTES"]
    OLIGODENDROCYTES -->|"produces"| myelin["myelin"]
    OLIGODENDROCYTES -->|"expressed in"| Prosaposin["Prosaposin"]
    OLIGODENDROCYTES -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    OLIGODENDROCYTES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    OLIGODENDROCYTES -->|"activates"| neuroinflammation["neuroinflammation"]
    OLIGODENDROCYTES -->|"activates"| neurodegeneration["neurodegeneration"]
    OLIGODENDROCYTES -->|"secretes"| IL6["IL6"]
    OLIGODENDROCYTES -->|"causes"| PARKIN["PARKIN"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON["PARKINSON"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON_S["PARKINSON'S"]
    HSPA1A["HSPA1A"] -->|"expressed in"| OLIGODENDROCYTES
    Microglia["Microglia"] -->|"interacts"| OLIGODENDROCYTES
    OxPC["OxPC"] -->|"causes"| OLIGODENDROCYTES
    BIN1["BIN1"] -->|"expressed in"| OLIGODENDROCYTES
    GPR37["GPR37"] -->|"expressed in"| OLIGODENDROCYTES
    DOPAMINERGIC_NEURONS["DOPAMINERGIC_NEURONS"] -->|"interacts"| OLIGODENDROCYTES
    OXPCS["OXPCS"] -->|"inhibits"| OLIGODENDROCYTES
    OxPCs["OxPCs"] -->|"causes"| OLIGODENDROCYTES
    AQP4["AQP4"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTE["ASTROCYTE"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTES["ASTROCYTES"] -->|"activates"| OLIGODENDROCYTES
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OLIGODENDROCYTES

Outgoing (282)

Target	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Alzheimer's Disease	involved_in	disease	0.95
Neurodegeneration	associated_with	process	0.95
Metabolic Reallocation	involved_in	process	0.95
Myelin	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.95
Neuroinflammation	causes	process	0.95
myelin	produces	protein	0.90
TAU	interacts_with	protein	0.90
Alzheimer's Disease Pathogenesis	contributes_to	process	0.90
Amyloid Pathology	interacts_with	process	0.90
Tau Pathology	interacts_with	process	0.90
Myelin Degeneration	contributes_to	process	0.90
multiple sclerosis	associated_with	disease	0.90
Parkinson's Disease	contributes_to	disease	0.90
Neurodegeneration	mediates	process	0.90
Neuroinflammation	mediates	process	0.90
Stress Response	associated_with	process	0.85
Disease Progression	contributes_to	process	0.85
Immune Modulation	mediates	process	0.85
Alzheimer'S Disease	contributes_to	disease	0.85
Inflammation	modulates	process	0.85
sphingolipid metabolism	active_in	pathway	0.85
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.85
Brain Ageing	associated_with	process	0.85
Dna Damage Response	expressed_in	pathway	0.85
Vascular Dementia	involved_in	disease	0.85
neurodegeneration	associated_with	process	0.80
multiple sclerosis	inhibits	disease	0.80
Synaptic Dysfunction	contributes_to	process	0.80
multiple sclerosis	activates	disease	0.80
MS lesions	expressed_in	process	0.80
Prosaposin	expressed_in	protein	0.80
Cellular Survival	mediates	process	0.80
NEUROINFLAMMATION	drives	process	0.80
demyelination	implicated_in	process	0.80
Oxidative Stress	involved_in	process	0.80
neurons	interacts_with	cell_type	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Apoptosis	protects_against	process	0.75
unfolded protein response	active_in	pathway	0.75
COHESIN COMPLEX	expressed_in	protein	0.75
Defense Mechanisms	mediates	process	0.75
neurodegeneration	activates	phenotype	0.72
NEUROINFLAMMATION	activates	phenotype	0.72
NEURODEGENERATION	causes	phenotype	0.72
neuroinflammation	activates	phenotype	0.72
NEURODEGENERATION	activates	phenotype	0.72
TREM2	activates	gene	0.70

Incoming (797)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
NEURON	activates	cell_type	0.95
MICROGLIA	regulates	cell_type	0.95
NEURON	regulates	cell_type	0.95
FERROPTOSIS	affects	process	0.90
MOG	expressed_in	gene	0.90
Oxidized Phosphatidylcholines	mediates	compound	0.90
OxPC	mediates	compound	0.90
33440165	shuttle	paper	0.90
neuroinflammation	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
SMS2	expressed_in	gene	0.90
36385529	aberrantly deposited in	paper	0.90
aging	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
Oligodendrocyte Precursor Cells	involved_in	cell_type	0.90
lipid metabolism	active_in	pathway	0.90
multiple sclerosis	affects	disease	0.90
BDNF	promotes	gene	0.90
Oxidized Phosphatidylcholines	targets	compound	0.90
38503282	accumulate sSNVs faster than	paper	0.90
38503282	accumulate indels slower than	paper	0.90
38503282	accumulated indels slower than	paper	0.90
axon	found_in	organelle	0.90
HSPA1A	expressed_in	gene	0.90
38503282	accumulated sSNVs faster than	paper	0.90
neurodegeneration	affects	disease	0.90
34225562	show vulnerability and myelin alterations	paper	0.90
GPR37	expressed_in	gene	0.88
GBA1	expressed_in	gene	0.85
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
Microglia	interacts_with	cell_type	0.85
PIEZO1	regulates	protein	0.85
Astrocytes	interacts_with	cell_type	0.85
AQP4	expressed_in	gene	0.80
RNA	expressed_in	gene	0.80
SGMS1	regulates	gene	0.80
BIN1	expressed_in	protein	0.80
NLRP3	regulates	gene	0.80
complement cascade	active_in	pathway	0.80
pyroptosis	active_in	pathway	0.80
NLRP3	activates	gene	0.80
OxPC	causes	chemical	0.80
BIN1	expressed_in	gene	0.80
MBP	expressed_in	gene	0.80
Parkinson's disease	affects	disease	0.80
Remyelinating Agents	targets	drug	0.80
Piezo1	regulates	gene	0.80
NLRP3	expressed_in	gene	0.80
SMPD1	expressed_in	gene	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.772	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.749	neuroinflammation	How do oligodendrocytes initiate neuroin

Mentioning Analyses (3)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.606

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.869

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
Molecular docking analysis of aminophylline binding targets	exploratory	depression	0.800	0.00	in silico molecular docking	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023	0
Pathogenesis of Alzheimer's Disease. [PMID:36613544]	Unknown	Int J Mol Sci	2022	0
Alzheimer's disease. [PMID:31753135]	["Soria Lopez, Jose A", "Gonz\u00e1lez,	Handbook of clinical neurology	2019	0
Alzheimer's disease. [PMID:28872215]	["Lane, C A", "Hardy, J", "Schott, J M"]	European journal of neurology	2018	0
Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715]	["Weller, Jason", "Budson, Andrew"]	F1000Research	2018	0

Debates (9)

Multi-agent debates referencing this entity

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

closed · Rounds: 4 · Score: 0.12 · 2026-04-27

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

closed · Rounds: 4 · Score: 0.42 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

closed · Rounds: 4 · Score: 0.47 · 2026-04-27

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

closed · Rounds: 4 · Score: 0.52 · 2026-04-27

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

closed · Rounds: 4 · Score: 0.72 · 2026-04-27

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.92 · 2026-04-03

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

Related Research

Hypotheses and analyses mentioning OLIGODENDROCYTES in their description or question text

No additional research found