gene

CLU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1150Connections

13Hypotheses

3Analyses

50Outgoing

50Incoming

5Experiments

3Debates

Summary

Clusterin (CLU/ApoJ) is an extracellular chaperone and the third most significant genetic risk factor for late-onset Alzheimer's disease. CLU binds amyloid-beta with high affinity, modulating its aggregation, clearance across the blood-brain barrier, and uptake by astrocytes and microglia. CLU also inhibits complement-mediated cell lysis and regulates apoptosis. AD risk variants in CLU alter its expression and splicing, reducing amyloid clearance efficiency. CLU levels are elevated in AD brain and CSF, serving as a potential biomarker. CLU cooperates with APOE in lipid transport and amyloid metabolism; the CLU-APOE interaction is a key node in AD pathogenesis.

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🧬 Gene Info

Gene Symbol	CLU
Full Name	Clusterin (Apolipoprotein J)
Aliases	Page for CLU Gene
Chromosome	8p21.1
Function	is a gene located on chromosome 8p21.
Primary Expression	Hippocampus, Cortex, Basal ganglia, Cerebellum
Exons	9
Pathways	Astrocyte Reactivity, Blood-Brain Barrier, Camp Signaling, Complement, Dysbiosis
UniProt ID	P10909
NCBI Gene ID	1115
Ensembl ID	ENSG00000120885
OMIM	185551
GeneCards	CLU
Human Protein Atlas	CLU
Associated Diseases	aging, Als, Alzheimer, Alzheimer disease
Interactions	ABCA7, ACE2, Actin, AD, AKT, ALZHEIMER
SciDEX Hypotheses	Hippocampus ages transcriptionally faster than cer
KG Connections	1149 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLU — AlphaFold P10909 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CLU["CLU"]
    CLU -->|"activates"| mitophagy["mitophagy"]
    CLU -->|"encodes"| clusterin["clusterin"]
    CLU -->|"activates"| neuronal_excitability["neuronal excitability"]
    CLU -->|"activates"| lipid_droplet_formation["lipid droplet formation"]
    CLU -->|"activates"| neuron_glia_lipid_transfer["neuron-glia lipid transfer"]
    CLU -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    CLU -->|"regulates"| Cancer["Cancer"]
    CLU -->|"interacts"| Alzheimer["Alzheimer"]
    CLU -->|"activates"| Als["Als"]
    BAX["BAX"] -->|"interacts"| CLU
    PPARG["PPARG"] -->|"activates"| CLU
    PPARGC1A["PPARGC1A"] -->|"activates"| CLU
    C1Q["C1Q"] -->|"activates"| CLU
    BIN1["BIN1"] -->|"activates"| CLU
    CDKN2A["CDKN2A"] -->|"expressed in"| CLU
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"expressed in"| CLU
    PRKCB["PRKCB"] -->|"expressed in"| CLU
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| CLU
    CANCER["CANCER"] -->|"expressed in"| CLU

Outgoing (790)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CLU	data_in	dataset_row	0.00
ad_genetic_risk_loci:CLU	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Clu	encodes	entity	0.95
Alzheimer's Disease	risk_factor_for	disease	0.95
Mitophagy	associated_with	process	0.95
MITOPHAGY	controls	process	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Amyloid Beta Aggregation	regulates	process	0.90
Mitochondrial Damage	modulates	process	0.90
Amyloid Accumulation	inhibits	process	0.90
Oral Cancer Cell Survival	contributes_to	phenotype	0.90
AMYLOID-Β	interacts_with	protein	0.90
Fibrillar Amyloid	downregulates	compound	0.90
Astrocyte Reactivity	modulates	process	0.90
Cognitive Resilience	associated_with	phenotype	0.88
Neuronal Cell Death	inhibits	process	0.85
Complement System	inhibits	pathway	0.85
Complement pathway	component_of	pathway	0.85
PPARGC1A	associated_with	gene	0.85
NF-κB Signaling	inhibits	pathway	0.85
Mitochondrial Damage	inhibits	phenotype	0.85
Amyloid Metabolism	regulates	process	0.85
Autophagic Machinery	associated_with	mechanism	0.85
Alzheimer Disease	risk_factor_for	disease	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
Alzheimer'S Disease	associated_with	disease	0.80
lipid metabolism	involved_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80
Cognitive Aging	risk_factor_for	phenotype	0.80
Aβ	clears	protein	0.80
Neuronal Apoptosis	modulates	process	0.80
Lipid Transport	mediates	process	0.80
Neuroinflammation	contributes_to	process	0.80
Memory	modulates	phenotype	0.80
Cognitive Function	protects_against	phenotype	0.80
Brain Inflammation	inhibits	process	0.80
C3	inhibits	protein	0.80
unfolded protein response	participates_in	pathway	0.80
Wnt Signaling	modulates	pathway	0.75
Copper Homeostasis	regulates	process	0.75
Aging	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Als	associated_with	disease	0.75
LC3	interacts_with	protein	0.74
CR1	associated_with	gene	0.74
mitophagy	activates	pathway	0.72

Incoming (360)

Source	Relation	Type	Str
ad_genetic_risk_loci:CLU	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CLU	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
APOE	associated_with	gene	0.98
CLU	encodes	protein	0.95
SORL1	regulates	gene	0.90
Astrocyte	expressed_in	cell_type	0.85
ALZHEIMER DISEASE	associated_with	gene	0.80
CD63	upregulates	gene	0.80
rs9331888	associated_with	biomarker	0.75
rs11136000	associated_with	biomarker	0.75
AMYLOID	associated_with	gene	0.74
APOE	expresses	gene	0.70
APP	expresses	gene	0.70
APOE	modulates	gene	0.70
CD33	regulates	gene	0.70
Exercise	upregulates	process	0.70
ALZHEIMER'S DISEASE	regulates	disease	0.66
ASTROCYTES	associated_with	cell_type	0.66
BIN1	associated_with	gene	0.66
CORTEX	regulates	brain_region	0.65
ASTROCYTES	increases	cell_type	0.65
NEUROINFLAMMATION	targets	phenotype	0.65
MICROGLIA	interacts_with	cell_type	0.65
ASTROCYTE	increases	cell_type	0.65
CD33	inhibits	gene	0.65
AKT	co_discussed	gene	0.65
LRRK2	regulates	gene	0.65
AKT	treats	gene	0.65
CD2AP	associated_with	gene	0.65
CD33	increases_risk	gene	0.65
ABCA1	associated_with	gene	0.65
BDNF	co_discussed	gene	0.65
MONOCYTES	interacts_with	cell_type	0.65
ATP8B1	interacts_with	gene	0.60
CD33	expressed_in	gene	0.60
APPBP2	activates	gene	0.60
PPARGC1A	activates	gene	0.60
ABCA7	expressed_in	gene	0.60
CRYAB	interacts_with	gene	0.60
PPARG	activates	gene	0.60
CD2AP	expressed_in	gene	0.60
CFH	implicated_in	gene	0.60
APOE	activates	gene	0.60
CR1	regulates	gene	0.60
CFH	associated_with	gene	0.60
EGFR	regulates	gene	0.60

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S	0.811	neurodegeneration	What are the cell-type-specific transcri
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
H6: miR-132/212 Cluster Silencing Disables Neuronal Chromati	0.660	neurodegeneration	Investigate mechanisms of epigenetic rep
Clusterin (APOJ) Secretion Deficit	0.660	neurodegeneration	Which specific factors in conditioned me
CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T	0.648	neurodegeneration	Does clusterin exacerbate or protect aga

G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclu	0.633	neurodegeneration	What determines the spatial organization
Steric Occlusion of G3BP1 Oligomerization Interface	0.630	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
CSF ApoE- and clusterin-rich lipoprotein particles stabilize	0.606	neurodegeneration	Which specific CSF molecular components
miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcr	0.520	neurodegeneration	What determines P2RY12 receptor expressi
Hippocampus ages transcriptionally faster than cerebellum, d	0.516	Alzheimer's disease	Allen Mouse Brain Aging Atlas: cross-age
Shift AQP4 Isoform/OAP Assembly Toward Clearance-Competent A	0.500	neurodegeneration	How can AQP4 be effectively targeted the
Kinesin-Dependent Peripheral Microtubule Transport Maintains	0.486	neurodegeneration	What determines the spatial organization
Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin	0.461	neurodegeneration	What determines the spatial organization

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived endothelial cell iron uptake with RLS CSF exposure	exploratory	restless legs syndrome	0.900	0.00	iPSC-derived human endothelial	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555]	Mishra AK, Jain S	ACS Chem Neurosci	2026	0
The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232]	Xie Z, Tu W, Ye XF, Hua L, Zhang X et al	Sci Rep	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452]	Akkaoui J, Devadoss D, Rodriguez MD, Ari	Neural Regen Res	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Genetic Burden and <i>APOE</i> Methylation in a Korean Multi-Generational Alzhei [PMID:41745359]	Eom Je-Hyun; Cho Mu-Yeol; Kim Ji-Won; Ki	Journal of personalized medici	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	Burdman Gabriel; Akkaoui Juliet; Colon N	Neurology international	2026	0
Posttraumatic stress disorder is associated with Alzheimer's disease-relevant mo [PMID:41960318]	Seijo MA, Yohannes PA, Rogers AL, Gonzal	Res Sq	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452]	Akkaoui J, Devadoss D, Rodriguez MD, Ari	Neural regeneration research	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0

Debates (3)

Multi-agent debates referencing this entity

CLU

Understanding Entity Pages

Summary

Wiki Pages (4)

CLU — Clusterin (Apolipoprotein J)

CLU-Clusterin Amyloid Clearance Dysfunction AD Causal Chain

Clusterin (CLU / Apolipoprotein J)

CLU Gene - Clusterin

Pathway Diagram

Outgoing (790)

Incoming (360)

Targeting Hypotheses (13)

Mentioning Analyses (3)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Senolytic therapy for age-related neurodegeneration

Experiments (5)

Related Papers (20)

Debates (3)

The abstract reveals contradictory evidence where clusterin is proposed as a pro

Despite the debate focusing on SEA-AD transcriptomic data, no actual gene expres

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP