Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MOG is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with AD, Aging, Als. Connected to 93 entities in the SciDEX knowledge graph.
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| Gene Symbol | MOG |
| Full Name | Myelin Oligodendrocyte Glycoprotein |
| Chromosome | 6p22.2 |
| Function | MOG is a type I transmembrane glycoprotein with an immunoglobulin-like domain. |
| Molecular Weight | 28 kDa |
| Pathways | Complement, Oxidative Phosphorylation |
| NCBI Gene ID | 4340 |
| Ensembl ID | ENSG00000137355 |
| GeneCards | MOG |
| Human Protein Atlas | MOG |
| Myelin surface localization | MOG is located on the outer surface of the myelin sheath, making it accessible to immune cells |
| Cell adhesion | MOG participates in oligodendrocyte process extension and myelin compaction |
| Complement activation | The extracellular domain can activate the complement cascade |
| Immunomodulation | Interacts with immune cells and may regulate T cell responses |
| Axon-oligodendrocyte signaling | May participate in bidirectional communication |
| Associated Diseases | AD, Aging, Als, Autoimmune, MOGAD |
| Known Drugs/Compounds | metformin |
| Interactions | AMPK, AND, APOPTOSIS, AQP4, ATG5, ATP |
| SciDEX Hypotheses | Oligodendrocyte White Matter Vulnerability |
| KG Connections | 277 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
MOG["MOG"]
MOGAD{"MOGAD"}
MOG -->|"biomarker for"| MOGAD
Aging{"Aging"}
MOG -->|"regulates"| Aging
Autoimmune{"Autoimmune"}
MOG -->|"associated with"| Autoimmune
Multiple_Sclerosis{"Multiple Sclerosis"}
MOG -->|"associated with"| Multiple_Sclerosis
Ms{"Ms"}
MOG -->|"therapeutic target"| Ms
MOG -->|"associated with"| Aging
MYELIN["MYELIN"]
MOG -->|"associated with"| MYELIN
OLIGODENDROCYTE["OLIGODENDROCYTE"]
MOG -->|"associated with"| OLIGODENDROCYTE
PLP1["PLP1"]
MOG -->|"associated with"| PLP1
MOG -->|"activates"| Autoimmune
Als{"Als"}
MOG -->|"biomarker for"| Als
MOG -->|"expressed in"| Multiple_Sclerosis
MBP["MBP"]
MBP -->|"associated with"| MOG
AQP4["AQP4"]
AQP4 -->|"associated with"| MOG
C1Q["C1Q"]
C1Q -->|"activates"| MOG
CD4["CD4"]
CD4 -->|"activates"| MOG
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"expressed in"| MOG
ATG5["ATG5"]
ATG5 -->|"activates"| MOG
AQUAPORIN_4["AQUAPORIN-4"]
AQUAPORIN_4 -->|"biomarker for"| MOG
MYELIN -->|"biomarker for"| MOG
AND["AND"]
AND -->|"biomarker for"| MOG
OLIGODENDROCYTE -->|"biomarker for"| MOG
style MOG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-f2c28aed24a7 | provides_data_for | dataset | 1.00 |
| MOGAD | associated_with | disease | 0.95 |
| MOGAD | biomarker_for | disease | 0.95 |
| MOG-Antibody Associated Disease | biomarker_for | disease | 0.95 |
| Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease | biomarker_for | disease | 0.95 |
| Myelin Oligodendrocyte Glycoprotein-Associated Disease | biomarker_for | disease | 0.95 |
| demyelination | implicated_in | process | 0.90 |
| oligodendrocytes | expressed_in | cell_type | 0.90 |
| MOG-IgG | interacts_with | protein | 0.85 |
| Hypermyelination | involved_in | phenotype | 0.85 |
| Autoimmune | activates | disease | 0.75 |
| OLIGODENDROCYTES | activates | cell_type | 0.70 |
| B CELLS | exacerbates | cell_type | 0.70 |
| OLIGODENDROCYTE | activates | gene | 0.70 |
| oligodendrocytes | causes | cell_type | 0.70 |
| oligodendrocytes | biomarker_for | cell_type | 0.70 |
| oligodendrocytes | associated_with | cell_type | 0.70 |
| ALS | activates | disease | 0.65 |
| OLIGODENDROCYTE | causes | cell_type | 0.65 |
| ROS | inhibits | phenotype | 0.65 |
| Als | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| PLP1 | associated_with | gene | 0.65 |
| Aging | regulates | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Multiple Sclerosis | expressed_in | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| MYELIN | associated_with | gene | 0.65 |
| Als | activates | disease | 0.65 |
| Multiple Sclerosis | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Autoimmune | inhibits | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| OLIGODENDROCYTE | associated_with | concept | 0.65 |
| Stroke | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| OLIGODENDROCYTE | interacts_with | cell_type | 0.65 |
| RELN | associated_with | gene | 0.60 |
| NEURON | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-f2c28aed24a7 | data_in | dataset | 1.00 |
| h-06cb8e75 | targets_gene | hypothesis | 0.90 |
| MYELIN | activates | gene | 0.80 |
| MBP | stabilizes | gene | 0.70 |
| AQP4 | interacts_with | gene | 0.70 |
| AQP4 | disrupts | gene | 0.70 |
| AQP4 | treats | gene | 0.70 |
| OLIG2 | causes | gene | 0.70 |
| MBP | associated_with | gene | 0.65 |
| OLIGODENDROCYTE | regulates | cell_type | 0.65 |
| MBP | regulates | gene | 0.65 |
| ASTROCYTE | regulates | cell_type | 0.65 |
| AQP4 | associated_with | gene | 0.65 |
| AXON | activates | gene | 0.60 |
| MYELIN | associated_with | gene | 0.60 |
| AQUAPORIN-4 | therapeutic_target | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| AQP4 | therapeutic_target | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| CNTF | activates | gene | 0.60 |
| MBP | causes | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| MAG | associated_with | gene | 0.60 |
| MAG | expresses | gene | 0.60 |
| CNP | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| AB | associated_with | gene | 0.60 |
| APOPTOSIS | treats | gene | 0.60 |
| EXOSOMES | treats | gene | 0.60 |
| OLIGODENDROCYTE | biomarker_for | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| metformin | targets | drug | 0.60 |
| CD4 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| SYN1 | activates | gene | 0.60 |
| MBP | activates | gene | 0.60 |
| RAC1 | activates | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| GFAP | regulates | gene | 0.60 |
| MBP | interacts_with | gene | 0.60 |
| OLIG2 | targets | gene | 0.60 |
| AQP4 | regulates | gene | 0.60 |
| AQP4 | biomarker_for | gene | 0.60 |
| CD9 | biomarker_for | gene | 0.60 |
| L1CAM | biomarker_for | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting EC-II parvalbumin interneurons to | 0.831 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Oligodendrocyte White Matter Vulnerability | 0.651 | neurodegeneration | Gene expression changes in aging mouse b |
| MOG-IgG induces spinal cord demyelination through Fcγ recept | 0.560 | neuroinflammation | What are the specific pathophysiological |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144] | Daood R, Naffaa ME, Azrilin O, Hassan F, | Clin Rheumatol | 2026 | 0 |
| Pathogenic mechanisms of action of autoantibody-mediated central nervous system [PMID:41831629] | Lerch M, Irani SR, Ramanathan S | Autoimmun Rev | 2026 | 0 |
| TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-Ig [PMID:41921125] | Vilaseca A, Filippatou AG, Said Y, Sechi | Neurol Neuroimmunol Neuroinfla | 2026 | 0 |
| Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PMID:41925507] | Flanagan EP, Hemingway C | Continuum (Minneap Minn) | 2026 | 0 |
| Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387] | Elosua-Bayés I, Cobo-Calvo A | Rev Neurol (Paris) | 2026 | 0 |
| Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Lear [PMID:39496109] | ["Pontillo G", "Prados F", "Colman J", " | Neurology | 2024 | 0 |
| NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early [PMID:39609868] | Tu H, Yeo XY, Zhang ZW, Zhou W, Tan JY, | Molecular neurodegeneration | 2024 | 0 |
| Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Diso [PMID:37429715] | ["Remlinger J", "Bagnoud M", "Meli I", " | Neurology(R) neuroimmunology & | 2023 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Longitudinal Retinal Changes in MOGAD. [PMID:35703428] | ["Oertel F", "Sotirchos E", "Zimmermann | Annals of neurology | 2022 | 0 |
| Re-identification of individuals in genomic datasets using public face images. [PMID:34788101] | Venkatesaramani R, Malin BA, Vorobeychik | Science advances | 2021 | 0 |
| Oligodendrocyte-Specific Deletion of [PMID:34502405] | ["Rajendran R", "Rajendran V", "Giraldo- | International journal of molec | 2021 | 0 |
| Cryo-EM structures of Toll-like receptors in complex with UNC93B1. [PMID:33432245] | Ishida H, Asami J, Zhang Z, Nishizawa T, | Nature structural & molecular | 2021 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning MOG in their description or question text
No additional research found