protein

MOG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

277Connections
3Hypotheses
1Analyses
50Outgoing
50Incoming
0Experiments
1Debates

Summary

MOG is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with AD, Aging, Als. Connected to 93 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolMOG
Full NameMyelin Oligodendrocyte Glycoprotein
Chromosome6p22.2
FunctionMOG is a type I transmembrane glycoprotein with an immunoglobulin-like domain.
Molecular Weight28 kDa
PathwaysComplement, Oxidative Phosphorylation
NCBI Gene ID4340
Ensembl IDENSG00000137355
GeneCardsMOG
Human Protein AtlasMOG
Myelin surface localizationMOG is located on the outer surface of the myelin sheath, making it accessible to immune cells
Cell adhesionMOG participates in oligodendrocyte process extension and myelin compaction
Complement activationThe extracellular domain can activate the complement cascade
ImmunomodulationInteracts with immune cells and may regulate T cell responses
Axon-oligodendrocyte signalingMay participate in bidirectional communication
Associated DiseasesAD, Aging, Als, Autoimmune, MOGAD
Known Drugs/Compoundsmetformin
InteractionsAMPK, AND, APOPTOSIS, AQP4, ATG5, ATP
SciDEX HypothesesOligodendrocyte White Matter Vulnerability
KG Connections277 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

MOG Gene

gene · 704 words

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

disease · 1759 words

MOG Protein

protein · 792 words

Pathway Diagram

graph TD
    MOG["MOG"]
    MOGAD{"MOGAD"}
    MOG -->|"biomarker for"| MOGAD
    Aging{"Aging"}
    MOG -->|"regulates"| Aging
    Autoimmune{"Autoimmune"}
    MOG -->|"associated with"| Autoimmune
    Multiple_Sclerosis{"Multiple Sclerosis"}
    MOG -->|"associated with"| Multiple_Sclerosis
    Ms{"Ms"}
    MOG -->|"therapeutic target"| Ms
    MOG -->|"associated with"| Aging
    MYELIN["MYELIN"]
    MOG -->|"associated with"| MYELIN
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    MOG -->|"associated with"| OLIGODENDROCYTE
    PLP1["PLP1"]
    MOG -->|"associated with"| PLP1
    MOG -->|"activates"| Autoimmune
    Als{"Als"}
    MOG -->|"biomarker for"| Als
    MOG -->|"expressed in"| Multiple_Sclerosis
    MBP["MBP"]
    MBP -->|"associated with"| MOG
    AQP4["AQP4"]
    AQP4 -->|"associated with"| MOG
    C1Q["C1Q"]
    C1Q -->|"activates"| MOG
    CD4["CD4"]
    CD4 -->|"activates"| MOG
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| MOG
    ATG5["ATG5"]
    ATG5 -->|"activates"| MOG
    AQUAPORIN_4["AQUAPORIN-4"]
    AQUAPORIN_4 -->|"biomarker for"| MOG
    MYELIN -->|"biomarker for"| MOG
    AND["AND"]
    AND -->|"biomarker for"| MOG
    OLIGODENDROCYTE -->|"biomarker for"| MOG
    style MOG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (172)

TargetRelationTypeStr
ds-f2c28aed24a7provides_data_fordataset1.00
MOGADassociated_withdisease0.95
MOGADbiomarker_fordisease0.95
MOG-Antibody Associated Diseasebiomarker_fordisease0.95
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Diseasebiomarker_fordisease0.95

Incoming (105)

SourceRelationTypeStr
ds-f2c28aed24a7data_indataset1.00
h-06cb8e75targets_genehypothesis0.90
MYELINactivatesgene0.80
MBPstabilizesgene0.70
AQP4interacts_withgene0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop tACS targeting EC-II parvalbumin interneurons to 0.831 Alzheimer's disease Circuit-level neural dynamics in neurode
Oligodendrocyte White Matter Vulnerability 0.651 neurodegeneration Gene expression changes in aging mouse b
MOG-IgG induces spinal cord demyelination through Fcγ recept 0.560 neuroinflammation What are the specific pathophysiological

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (13)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144] Daood R, Naffaa ME, Azrilin O, Hassan F, Clin Rheumatol 2026 0
Pathogenic mechanisms of action of autoantibody-mediated central nervous system [PMID:41831629] Lerch M, Irani SR, Ramanathan S Autoimmun Rev 2026 0
TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-Ig [PMID:41921125] Vilaseca A, Filippatou AG, Said Y, Sechi Neurol Neuroimmunol Neuroinfla 2026 0
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PMID:41925507] Flanagan EP, Hemingway C Continuum (Minneap Minn) 2026 0
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387] Elosua-Bayés I, Cobo-Calvo A Rev Neurol (Paris) 2026 0
Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Lear [PMID:39496109] ["Pontillo G", "Prados F", "Colman J", " Neurology 2024 0
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early [PMID:39609868] Tu H, Yeo XY, Zhang ZW, Zhou W, Tan JY, Molecular neurodegeneration 2024 0
Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Diso [PMID:37429715] ["Remlinger J", "Bagnoud M", "Meli I", " Neurology(R) neuroimmunology & 2023 0
Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] Torrini C, Nguyen TTT, Shu C, Mela A, Hu Molecular cell 2022 0
Longitudinal Retinal Changes in MOGAD. [PMID:35703428] ["Oertel F", "Sotirchos E", "Zimmermann Annals of neurology 2022 0
Re-identification of individuals in genomic datasets using public face images. [PMID:34788101] Venkatesaramani R, Malin BA, Vorobeychik Science advances 2021 0
Oligodendrocyte-Specific Deletion of [PMID:34502405] ["Rajendran R", "Rajendran V", "Giraldo- International journal of molec 2021 0
Cryo-EM structures of Toll-like receptors in complex with UNC93B1. [PMID:33432245] Ishida H, Asami J, Zhang Z, Nishizawa T, Nature structural & molecular 2021 0

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning MOG in their description or question text

No additional research found