cell_type

MICROGLIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10464Connections

30Hypotheses

5Analyses

50Outgoing

50Incoming

7Experiments

5Debates

Summary

Resident immune cells of the central nervous system. Microglia survey the brain parenchyma, clear debris, prune synapses, and respond to injury. In neurodegenerative diseases, chronic microglial activation drives neuroinflammation through complement cascade and cytokine release.

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🧫 Cell Type Info

Cell Type	MICROGLIA
Also Known As	Microglial cells, Brain-resident macrophages
Definition	Resident immune cells of the central nervous system derived from yolk sac progenitors
Functions	Immune surveillance, Synaptic pruning, Phagocytosis, Cytokine production, Debris clearance
Key Markers	IBA1, CD11b, CX3CR1, P2RY12, TMEM119, TREM2
States	Homeostatic, Disease-associated (DAM), Activated, Phagocytic, Senescent
Key Pathways	TREM2-DAP12 signaling, TLR4-NF-kB, CSF1R signaling, Complement cascade, cGAS-STING
Associated Diseases	Alzheimer's disease, Parkinson's disease, Multiple sclerosis, ALS, Nasu-Hakola disease
Discovery	First described by Pío del Río Hortega in 1919
Linked Hypotheses	368 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Microglia Activation Mechanism

mechanism · 3164 words

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Pathway Diagram

graph TD
    subgraph Therapeutic["Therapeutic"]
        MICROGLIA["MICROGLIA"] -->|"expressed in"| TREM2["TREM2"]
        TREM2_3["TREM2"] -->|"expressed in"| MICROGLIA["MICROGLIA"]
    end
    subgraph Pathology["Pathology"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| NEURON["NEURON"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| TNF["TNF"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| SNCA["SNCA"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| TAU["TAU"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| TREM2_1["TREM2"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
        AMYLOID["AMYLOID"] -->|"associated with"| MICROGLIA["MICROGLIA"]
        APOE["APOE"] -->|"associated with"| MICROGLIA["MICROGLIA"]
    end
    subgraph Signaling["Signaling"]
        MICROGLIA["MICROGLIA"] -->|"activates"| TREM2_2["TREM2"]
        INFLAMMATION["INFLAMMATION"] -->|"activates"| MICROGLIA["MICROGLIA"]
        C1Q["C1Q"] -->|"activates"| MICROGLIA["MICROGLIA"]
        TREM2_4["TREM2"] -->|"regulates"| MICROGLIA["MICROGLIA"]
    end
    style MICROGLIA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style TREM2 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SNCA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TREM2_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TREM2_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TREM2_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style C1Q fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TREM2_4 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (4663)

Target	Relation	Type	Str
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Als	expressed_in	disease	1.00
Immune Response	activates	pathway	1.00
Neurodegeneration	inhibits	disease	1.00
Blood-Brain Barrier	activates	pathway	1.00
Ischemia	regulates	disease	1.00
Phagocytosis	activates	pathway	1.00
Dementia	therapeutic_target	disease	1.00
Alzheimer	inhibits	disease	1.00
C1Q	associated_with	gene	1.00
Stroke	activates	disease	1.00
Toll-Like Receptor	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Neuroinflammation	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Aging	activates	disease	1.00
TAU	activates	gene	1.00
Inflammation	regulates	disease	1.00
Amyotrophic Lateral Sclerosis	activates	disease	1.00
Neuroinflammation	regulates	disease	1.00
Aging	therapeutic_target	disease	1.00
TNF	activates	gene	1.00
Inflammation	inhibits	disease	1.00
Neuroinflammation	activates	disease	1.00
Parkinson	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Autophagy	activates	pathway	1.00
C3	associated_with	gene	1.00
SYNUCLEIN	associated_with	protein	1.00
Parkinson	associated_with	disease	1.00
TNF	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Dementia	activates	disease	1.00
NEURON	associated_with	gene	1.00
Mitophagy	activates	pathway	1.00
Alzheimer	activates	disease	1.00
NEUROINFLAMMATION	inhibits	gene	1.00
Als	associated_with	disease	1.00
TREM2	expressed_in	protein	1.00
SNCA	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Alzheimer	associated_with	disease	1.00
Als	activates	disease	1.00
TREM2	associated_with	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Inflammation	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Alzheimer	interacts_with	disease	1.00

Incoming (5801)

Source	Relation	Type	Str
AMYLOID	inhibits	gene	1.00
INFLAMMATION	inhibits	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
STROKE	activates	gene	1.00
AMYLOID	activates	gene	1.00
NLRP3	activates	gene	1.00
STROKE	regulates	gene	1.00
NEURON	activates	gene	1.00
ASTROCYTES	activates	gene	1.00
TREM2	activates	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
PHAGOCYTOSIS	activates	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NF-ΚB	activates	gene	1.00
ALS	associated_with	gene	1.00
ASTROCYTES	regulates	gene	1.00
C1Q	activates	protein	1.00
TREM2	expressed_in	gene	1.00
APOE	associated_with	gene	1.00
COMPLEMENT	activates	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	1.00
ASTROCYTES	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-f2c28aed24a7	data_in	dataset	1.00
ALZHEIMER'S DISEASE	causes	gene	1.00
ALZHEIMER'S DISEASE	targets	gene	1.00
AMYLOID	associated_with	gene	1.00
AKT	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
ent-gene-28e2cb01	expressed_in	gene	1.00
AGING	associated_with	gene	1.00
TREM2	regulates	protein	1.00
MITOPHAGY	activates	gene	1.00
IL-6	associated_with	gene	1.00
NEUROINFLAMMATION	causes	gene	1.00
APP	associated_with	gene	1.00
INFLAMMATION	activates	phenotype	1.00
TREM2	associated_with	gene	1.00
AMYLOID	targets	gene	1.00
APOPTOSIS	associated_with	gene	1.00
PARKINSON'S DISEASE	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
MICROGLIA ACTIVATION	activates	gene	1.00
TNF-Α	activates	gene	1.00
APP/PS1	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
NEURODEGENERATION	inhibits	gene	1.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SCFA Deficiency Disrupts Microglial Homeostasis and Promotes	5.500	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.990	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Dependent Microglial Senescence Transition	0.950	neurodegeneration	Gene expression changes in aging mouse b
PLCG2 Allosteric Modulation as a Precision Therapeutic for T	0.941	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.921	neurodegeneration	Lipid raft composition changes in synapt

TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.910	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.907	neurodegeneration	Gene expression changes in aging mouse b
CSF1R Inhibition-Mediated Microglial Replacement as a State	0.898	neurodegeneration	How do different microglial subtypes (DA
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.895	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from	0.887	neurodegeneration	How does APOE4's beneficial immune funct
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.880	neurodegeneration	Gene expression changes in aging mouse b
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.879	neurodegeneration	How do different microglial subtypes (DA
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.875	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.869	neurodegeneration	Gene expression changes in aging mouse b
Microglial Senescence Prevention via TREM2/SASP Axis	0.847	neurodegeneration	View
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.847	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.812	neuroscience	Circuit-level neural dynamics in neurode
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion	0.808	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.806	neuroinflammation	How do oligodendrocytes initiate neuroin
Prime Editing Precision Correction of APOE4 to APOE3 in Micr	0.803	neurodegeneration	CRISPR-based therapeutic approaches for
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
TREM2 Deficiency Drives Microglial Senescence via Lipid Meta	0.800	neurodegeneration	What molecular mechanisms drive microgli
Microglial TREM2-SYK Pathway Enhancement	0.798	neurodegeneration	Cell type vulnerability in Alzheimers Di
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.796	neurodegeneration	Senolytic therapy for age-related neurod
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.792	neuroscience	Circuit-level neural dynamics in neurode
Senescent Microglia Resolution via Maresins-Senolytics Combi	0.784	neurodegeneration	Neuroinflammation resolution mechanisms
TREM2-mediated microglial tau clearance enhancement	0.780	neurodegeneration	Tau propagation mechanisms and therapeut

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.682

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639

Experiments (7)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.800	Mouse (5xFAD/TREM2-/-)	completed	N/A
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.800	Mouse (5xFAD/TREM2-/-)	completed	N/A
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.800	Mouse (5xFAD/TREM2-/-)	in_progress	N/A
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.800	Mouse (5xFAD/TREM2-/-)	completed	N/A
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.800	Mouse (5xFAD/TREM2-/-)	completed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	endocycling mammalian cells	proposed	N/A
TREM2 KO amyloid pathology study	validation	Alzheimers Disease	0.200	Mouse (5xFAD/TREM2-/-)	in_progress	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Mol Neurodegener	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312]	["Mehrabadi S"]	Current aging science	2026	0
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026	0
Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384]	["Siew J", "Lee C", "Chen H", "Lin H", "	Brain : a journal of neurology	2026	0
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026	0
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026	0
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962]	Baek S, Jang J, Yeo S, Jung HJ, Choe Y	Signal transduction and target	2026	0
Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935]	["Konstantoulea K", "Ramakers M", "Borri	Proceedings of the National Ac	2026	0
Microglia, Trem2, and Neurodegeneration. [PMID:38769824]	Shi Q, Gutierrez RA, Bhat MA	Neuroscientist	2025	0
Microglia, Trem2, and Neurodegeneration. [PMID:38769824]	Shi Q, Gutierrez RA, Bhat MA	The Neuroscientist : a review	2025	0

Debates (5)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

The authors identify SPI1 as a potential transcription factor regulating the hub

closed · Rounds: 4 · Score: 0.93 · 2026-04-09

The debate mentioned gene expression profiling but did not specify which neural

closed · Rounds: 4 · Score: 0.93 · 2026-04-03

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning MICROGLIA in their description or question text

TREM2-ASM Crosstalk in Microglial Lysosomal Senescence

Score: 0.910 · neurodegeneration · 2026-04-12

## Mechanistic Overview TREM2-ASM Crosstalk in Microglial Lysosomal Senescence starts from the claim that modulating SMP

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration

Score: 0.907 · neurodegeneration · 2026-04-12

## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration starts from the claim that mo

CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset

Score: 0.898 · neurodegeneration · 2026-04-16

## Mechanistic Overview CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset starts from the cla

SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence

Score: 0.895 · neurodegeneration · 2026-04-12

## Mechanistic Overview SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence starts from the claim that modu

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Score: 0.892 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration starts from the claim that mod

H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to A

Score: 0.887 · neurodegeneration · 2026-04-14

## Mechanistic Overview H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration

Score: 0.880 · neurodegeneration · 2026-04-07

## **Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) serves as a criti

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.879 · neurodegeneration · 2026-04-16

## Mechanistic Overview Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration

Score: 0.875 · neurodegeneration · 2026-04-07

**Molecular Mechanism and Rationale** The TREM2-mediated astrocyte-microglia cross-talk mechanism represents a complex

TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence

Score: 0.869 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence starts from the claim that mod

Microglial Senescence Prevention via TREM2/SASP Axis

Score: 0.847 · neurodegeneration · 2026-04-17

## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y

ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

Score: 0.847 · Alzheimer's Disease · 2026-04-02

## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia starts from the claim that modu

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot

Score: 0.843 · neurodegeneration · 2026-04-16

## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuro

Score: 0.824 · neurodegeneration · 2026-04-05

## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in

TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

Score: 0.812 · neuroscience · 2026-04-12

## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance starts from the claim