concept

OLIGODENDROCYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1646Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

OLIGODENDROCYTE is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 369 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	OLIGODENDROCYTE
Key Genes/Proteins	ABCA1, ACHE, ACTB, ADAM10, AGING, AKT
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER'S
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oligodendrocyte Lineage in Multiple System Atrophy

cell · 675 words

→

Pathway Diagram

graph TD
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
    OLIGODENDROCYTE -->|"regulates"| Myelin["Myelin"]
    OLIGODENDROCYTE -->|"regulates"| Aging["Aging"]
    OLIGODENDROCYTE -->|"activates"| Inflammation["Inflammation"]
    OLIGODENDROCYTE -->|"inhibits"| ALS["ALS"]
    OLIGODENDROCYTE -->|"inhibits"| Autoimmune["Autoimmune"]
    OLIGODENDROCYTE -->|"inhibits"| GPR37["GPR37"]
    OLIGODENDROCYTE -->|"inhibits"| Myelination["Myelination"]
    OLIGODENDROCYTE -->|"activates"| INFLAMMATION["INFLAMMATION"]
    MLKL["MLKL"] -->|"activates"| OLIGODENDROCYTE
    OPTN["OPTN"] -.protects against.-> OLIGODENDROCYTE
    AQUAPORIN_4["AQUAPORIN-4"] -.biomarker for.-> OLIGODENDROCYTE
    MYELIN["MYELIN"] -.biomarker for.-> OLIGODENDROCYTE
    MOG["MOG"] -.biomarker for.-> OLIGODENDROCYTE
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| OLIGODENDROCYTE
    BANG["BANG"] -->|"activates"| OLIGODENDROCYTE
    COMPLEMENT["COMPLEMENT"] -->|"causes"| OLIGODENDROCYTE
    AQP4["AQP4"] -->|"causes"| OLIGODENDROCYTE

Outgoing (647)

Target	Relation	Type	Str
Myelin Degeneration	contributes_to	phenotype	0.95
Alzheimer'S Disease	involved_in	disease	0.95
Myelin	associated_with	structure	0.95
Remyelination	involved_in	process	0.90
Neuroinflammation	associated_with	process	0.90
Excitotoxicity	mediates	process	0.90
Neuroinflammation	mediates	process	0.90
Neurodegeneration	associated_with	process	0.90
Active Lesion Rim	involved_in	phenotype	0.90
Parkinson'S Disease	involved_in	disease	0.90
neurodegeneration	drives	process	0.90
neuroinflammation	drives	process	0.90
MICROGLIA	activates	gene	0.90
Als	activates	disease	0.85
Axonal Myelination	involved_in	process	0.85
Multiple Sclerosis	associated_with	disease	0.85
Multiple Sclerosis	therapeutic_target	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Inflammatory Genes	upregulates	process	0.80
MYELIN	associated_with	gene	0.80
ASTROCYTE	activates	gene	0.80
Als	therapeutic_target	disease	0.75
Neurodegeneration	activates	disease	0.75
Autoimmune	activates	disease	0.75
Alzheimer's disease	implicated_in	disease	0.75
Stroke	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
Alzheimer	inhibits	disease	0.75
Dementia	inhibits	disease	0.75
Autoimmune	inhibits	disease	0.75
NEURON	inhibits	gene	0.70
AMYLOID-Β PLAQUES	inhibits	gene	0.70
MICROGLIA	inhibits	gene	0.70
DEMENTIA	inhibits	gene	0.70
ALZHEIMER	inhibits	gene	0.70
Wnt	inhibits	pathway	0.70
AKT	inhibits	gene	0.70
AMYLOID	inhibits	gene	0.70
Mtor	inhibits	pathway	0.70
ASTROCYTES	inhibits	gene	0.70
Pi3K/Akt	inhibits	pathway	0.70
P53	inhibits	gene	0.70
MTOR	inhibits	gene	0.70
GENES	inhibits	gene	0.70
Differentiation	activates	pathway	0.70
SENESCENCE	treats	phenotype	0.70
Apoptosis	activates	pathway	0.70
Myelin	regulates	entity	0.70

Incoming (999)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	1.00
ASTROCYTES	associated_with	gene	0.98
MICROGLIA	associated_with	gene	0.98
COMPLEMENT CASCADE	causes	entity	0.90
ALZHEIMER'S DISEASE	associated_with	gene	0.90
Multiple Sclerosis	causes	disease	0.90
Multiple Sclerosis	downregulates	disease	0.90
Ferroptosis	expressed_in	process	0.90
MYELIN	activates	gene	0.90
APOE4	expressed_in	gene	0.88
IGF1	promotes	protein	0.88
Cholesterol Metabolism	expressed_in	pathway	0.85
Microglia	interacts_with	cell_type	0.85
Α-SYNUCLEIN	expressed_in	protein	0.80
SERPINA3N	expressed_in	gene	0.75
OPC	associated_with	cell_type	0.75
MYELIN	associated_with	gene	0.75
TAU	associated_with	protein	0.74
NEUROINFLAMMATION	associated_with	gene	0.74
ASTROCYTE	associated_with	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
MLKL	activates	protein	0.70
ASTROCYTES	regulates	cell_type	0.70
MYELIN	inhibits	gene	0.70
HDAC3	regulates	gene	0.70
HDAC3	treats	gene	0.70
OPTN	protects_against	protein	0.70
HDAC3	inhibits	gene	0.70
HK2	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
BMP4	produces	gene	0.70
INFLAMMATION	activates	gene	0.70
HK2	inhibits	gene	0.70
NEURODEGENERATION	causes	disease	0.70
MICROGLIAL ACTIVATION	stabilizes	phenotype	0.70
NEURODEGENERATION	activates	gene	0.70
MICROGLIAL ACTIVATION	activates	phenotype	0.70
MOG	activates	gene	0.70
AMYLOID	associated_with	gene	0.66
JUN	associated_with	gene	0.66
APP	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
HDAC3	associated_with	gene	0.65
OLIG2	associated_with	gene	0.65
FUS	co_discussed	gene	0.65
MOG	associated_with	gene	0.65
MBP	associated_with	gene	0.65
BACE1	co_discussed	gene	0.65
OLIG2	co_discussed	gene	0.65
NRF2	inhibits	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03