gene

ALZHEIMER DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1763Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ALZHEIMER DISEASE is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with ALS, Aging, Als. Connected to 753 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ALZHEIMER DISEASE
Primary Expression	Ca1, Cortex, Hippocampus
Pathways	Autophagy, Oxidative Stress, Stem Cell, Complement, Immune Response
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Atherosclerosis
Known Drugs/Compounds	ANTI-AΒ ANTIBODIES, ds-cRNA
Interactions	ABCA1, ABCD3, ABI3, ACE, ACHE, ADAM10
KG Connections	1343 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Ms["Ms"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Cancer["Cancer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Diabetes["Diabetes"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Alzheimer_1["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Anxiety["Anxiety"]
    TREM2["TREM2"] -->|"associated"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    AKT1["AKT1"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    EGFR["EGFR"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    style ALZHEIMER_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (948)

Target	Relation	Type	Str
Alzheimer	activates	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Dementia	biomarker_for	disease	1.00
Als	therapeutic_target	disease	1.00
Alzheimer	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Aging	associated_with	disease	1.00
Als	associated_with	disease	1.00
Als	activates	disease	1.00
Neurodegeneration	biomarker_for	disease	0.95
Neurodegeneration	therapeutic_target	disease	0.95
Molecular Heterogeneity	associated_with	process	0.95
Alzheimer	biomarker_for	disease	0.95
Parkinson	associated_with	disease	0.95
Inflammation	associated_with	disease	0.95
Amyloid Beta 42/40	markers	protein	0.90
TREM2	associated_with	gene	0.90
APOE4	markers	protein	0.90
ANTI-AΒ ANTIBODIES	targets	drug	0.90
P-Tau	markers	protein	0.90
PSEN1	associated_with	gene	0.90
Premature Senescence	causes	phenotype	0.90
Autophagy	activates	pathway	0.90
DEMENTIA	biomarker_for	gene	0.90
ALZHEIMER	associated_with	gene	0.90
APOE	activates	gene	0.90
ALZHEIMER	activates	gene	0.90
Inflammation	therapeutic_target	disease	0.85
Alzheimer	causes	disease	0.85
Neurodegeneration	inhibits	disease	0.85
Cancer	associated_with	disease	0.85
Dementia	associated_with	disease	0.85
Aging	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Neuroinflammation	associated_with	disease	0.85
Obesity	associated_with	disease	0.85
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
Aging	biomarker_for	disease	0.85
Als	biomarker_for	disease	0.85
CD33	associated_with	gene	0.80
SORL1	associated_with	gene	0.80
CD2AP	associated_with	gene	0.80
SIGLEC11	associated_with	gene	0.80
PTK2B	associated_with	gene	0.80
BLNK	associated_with	gene	0.80
PLCG2	associated_with	gene	0.80
SPI1	associated_with	gene	0.80
TMEM106B	associated_with	gene	0.80
LRP1	associated_with	gene	0.80
ADAM17	associated_with	gene	0.80

Incoming (815)

Source	Relation	Type	Str
ALZHEIMER	therapeutic_target	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
TAU	associated_with	gene	1.00
ALZHEIMER	activates	gene	1.00
AMYLOID	activates	gene	1.00
AGING	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
Blood Test	biomarker_for	biomarker	0.98
Amyloid Probability Score 2	biomarker_for	biomarker	0.98
APOE	associated_with	gene	0.95
ISG15	implicated_in	gene	0.95
MAPT	biomarker_for	protein	0.95
Amyloid-Beta 40	biomarker_for	protein	0.95
P-Tau217	biomarker_for	biomarker	0.95
TAU	associated_with	protein	0.95
Amyloid-Beta 42	biomarker_for	protein	0.95
Macrophages	contributes_to	cell_type	0.95
Immune Activation	contributes_to	process	0.95
Phosphorylated Tau 217	biomarker_for	biomarker	0.95
MAPT	causes	gene	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
Amyloid-beta	biomarker_for	biomarker	0.95
Γ-SECRETASE	involved_in	enzyme	0.95
APOE ε4	risk_factor_for	protein	0.95
AMYLOID-Β	associated_with	protein	0.95
Aβ42:Aβ40 Ratio	biomarker_for	biomarker	0.95
Anti-Aβ Antibodies	treats	drug	0.95
APOE	protects_against	gene	0.95
AMYLOID BETA	involved_in	protein	0.95
Microglial Phagocytosis	causes	process	0.95
APOE ε4 Allele	risk_factor_for	biomarker	0.95
Microglia	contributes_to	cell_type	0.95
Phosphorylated Tau at Threonine 181	biomarker_for	biomarker	0.95
Amyloid-Beta Plaque Deposition	biomarker_for	biomarker	0.95
Oxidative Stress	contributes_to	process	0.95
AMYLOID-BETA	associated_with	protein	0.95
Neuroinflammation	associated_with	process	0.95
Donanemab	treats	drug	0.95
Cellular Senescence	contributes_to	process	0.95
Neurofibrillary Tangles	associated_with	phenotype	0.95
Amyloid Reduction	therapeutic_target	mechanism	0.95
Neuritic Plaques	associated_with	phenotype	0.95
BETA-AMYLOID	biomarker_for	protein	0.95
TAU	biomarker_for	protein	0.95
Amyloid-β	biomarker_for	biomarker	0.95
Amyloid-Beta Accumulation	contributes_to	phenotype	0.95
Amyloid-β Accumulation	contributes_to	phenotype	0.95
APOE*ε4	risk_factor_for	biomarker	0.95
Ageing	risk_factor_for	process	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.583

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does gene expression change across age groups (young/middle/old) in hippocam

active · Rounds: 4 · Score: 1.00 · 2026-04-24

Related Research

Hypotheses and analyses mentioning ALZHEIMER DISEASE in their description or question text

No additional research found