gene

MAG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

16Hypotheses

0Analyses

50Outgoing

47Incoming

8Experiments

0Debates

Summary

MAG is a gene implicated in neurodegeneration research. Key relationships include: activates, contributes to, inhibits. Associated with Als, Inflammation, Multiple Sclerosis. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAG
Full Name	Myelin-Associated Glycoprotein
Chromosome	19q13.12
Protein Type	Type I membrane protein, Siglec family
Function	is a critical component of the myelin sheath in the central and peripheral nervous systems.
Pathways	Apoptosis, Oxidative Stress
UniProt ID	P20916
NCBI Gene ID	4099
Ensembl ID	ENSG00000141670
OMIM	159460
GeneCards	MAG
Human Protein Atlas	MAG
Extracellular domain	Contains immunoglobulin-like domains that mediate sialic acid binding
Transmembrane domain	Single pass membrane spanning region
Cytoplasmic domain	Contains motifs for intracellular signaling and protein interactions
Associated Diseases	Als, Alzheimer
Known Drugs/Compounds	aducanumab
Interactions	AND, APOPTOSIS, App, ASTROCYTE, AXONAL MITOCHONDRIAL TRANSPORT, CD33
KG Connections	116 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAG — AlphaFold P20916 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAG["MAG"]
    MIRO1["MIRO1"]
    MAG -->|"inhibits"| MIRO1
    AXONAL_MITOCHONDRIAL_TRANSPORT["AXONAL MITOCHONDRIAL TRANSPORT"]
    MAG -->|"inhibits"| AXONAL_MITOCHONDRIAL_TRANSPORT
    neurodegeneration["neurodegeneration"]
    MAG -->|"implicated in"| neurodegeneration
    CNTN6["CNTN6"]
    CNTN6 -->|"upregulates"| MAG
    HDAC6["HDAC6"]
    HDAC6 -->|"inhibits"| MAG
    RHOA["RHOA"]
    RHOA -->|"activates"| MAG
    style MAG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
oligodendrocytes	expressed_in	cell_type	0.70
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	inhibits	disease	0.65
Inflammation	contributes_to	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
MBP	biomarker_for	gene	0.60
SIGLEC11	interacts_with	gene	0.60
schizophrenia	interacts_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
PLP1	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
ATP	contributes_to	gene	0.60
MBP	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	inhibits	cell_type	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Myelination	inhibits	pathway	0.60
Ras	inhibits	protein	0.60
Neural Progenitor	inhibits	cell_type	0.60
Hemoglobin	expressed_in	protein	0.60
Oligodendrocyte	inhibits	cell_type	0.60
MBP	expresses	gene	0.60
MOG	expresses	gene	0.60
OLIGODENDROCYTE	expresses	cell_type	0.60
OLIGODENDROCYTES	expresses	cell_type	0.60
PD	expresses	gene	0.60
PLP1	expresses	gene	0.60
Aβ	regulates	protein	0.60
OLIG1	inhibits	gene	0.60
App	inhibits	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
autism spectrum disorder	interacts_with	disease	0.60
OLIGODENDROCYTE	markers	cell_type	0.60
PLP1	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
PDGF	markers	gene	0.60
PERICYTE	markers	cell_type	0.60
MOG	associated_with	gene	0.60
RELN	associated_with	gene	0.60
MIRO1	inhibits	gene	0.60
HK1	regulates	gene	0.60
PLCB1	regulates	gene	0.60

Incoming (47)

Source	Relation	Type	Str
BIN1	biomarker_for	gene	0.70
CNTN6	upregulates	gene	0.70
INFLAMMATION	activates	phenotype	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.60
PLP1	inhibits	gene	0.60
AD	markers	gene	0.60
MYELIN	inhibits	gene	0.60
MOG	activates	gene	0.60
MBP	activates	gene	0.60
CD81	regulates	gene	0.60
GDI2	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MYELIN	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
GENES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
AND	inhibits	gene	0.60
OLIG1	inhibits	gene	0.60
GPR37	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	regulates	gene	0.60
aducanumab	targets	drug	0.60
APOE4	associated_with	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
IBA1	regulates	gene	0.60
BIN1	associated_with	gene	0.60
CNP	associated_with	gene	0.60
HDAC6	inhibits	gene	0.60
RHOA	activates	gene	0.60
HK1	regulates	gene	0.60
CAPZB	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
MBP	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
PLCB1	regulates	gene	0.60
HK1	co_expressed_with	gene	0.50
GDI2	co_expressed_with	gene	0.50
ADUCANUMAB	associated_with	drug	0.45
APOE	co_discussed	gene	0.40
GFAP	co_discussed	gene	0.40
ASTROCYTE	co_discussed	cell_type	0.40

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.887	-	Do β-amyloid plaques and neurofibrillary
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act
Mitochondrial ROS from complex I and cardiolipin instability	0.640	neurodegeneration	What mechanisms drive the self-amplifyin
HBOT at 1.5 ATA for 60 min induces hormetic response via Nrf	0.640	neurodegeneration	What are the optimal oxygen pressure, du

Microglial TREM2 downregulation impairs damage-associated re	0.628	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Neurovascular Permeability Score (NVPS): Composite Plasma +	0.600	-	Blood-brain barrier permeability changes
P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming	0.560	biomarkers	What biomarkers can reliably detect micr
P2Y6R activation by UDP from damaged neurons drives microgli	0.540	neurodegeneration	Which tau propagation mechanism predomin
PI3P Generation at Damaged Lysosomes Promotes Membrane Repai	0.530	neurodegeneration	How does controlled lysosomal membrane p
Telomere Attrition and DNA Damage Response Activation Induce	0.520	neurodegeneration	What molecular mechanisms drive microgli
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu
Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling	0.453	neuroinflammation	What molecular mechanisms mediate SPP1-i
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase
GrimAge Acceleration as a Cell-Type-Resolved CSF Biomarker P	0.351	-	Epigenetic clocks as biomarkers for Alzh

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived endothelial cell iron uptake with RLS CSF exposure	exploratory	restless legs syndrome	0.900	0.00	iPSC-derived human endothelial	proposed	N/A
PH-PS treatment in 5×FAD Alzheimer's disease mice	validation	Alzheimer's disease	0.900	0.00	5×FAD transgenic mice	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026	0
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026	0
A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal [PMID:41365298]	Xu Y, Chen X, Fang R, Wang X, Zhang Y et	Immunity	2026	0
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026	0
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026	0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026	0
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086]	Zhao Q, Huang R, Wang C, Hu J, Nie R et	Cancer Cell	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAG in their description or question text

MAG

Understanding Entity Pages

Summary

Wiki Pages (3)

MAG Gene

LY-3372689 MAGNOLIA Trial - Phase 2 in Alzheimer's Disease

DLG1 — Discs Large Homolog 1 Protein (MAGUK Scaffold)

Pathway Diagram

Outgoing (69)

Incoming (47)

Targeting Hypotheses (16)

Mentioning Analyses (0)

Experiments (8)

Related Papers (20)

Debates (0)

Related Research

Microglial TREM2 downregulation impairs damage-associated response in late-stage

Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa

P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming

P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and

PI3P Generation at Damaged Lysosomes Promotes Membrane Repair

Telomere Attrition and DNA Damage Response Activation Induces Microglial Senesce

Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-

Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling

DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop

GrimAge Acceleration as a Cell-Type-Resolved CSF Biomarker Panel for Early AD St