concept

OLIGODENDROCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1007Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

OLIGODENDROCYTES is a concept in neurodegeneration research. Key relationships include: co discussed, expressed in, activates. Associated with CANCER, DEMENTIA, NEURODEGENERATION. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTES
Key Genes/Proteins	ACHE, ADAM10, AMPK, AMYLOID, amyotrophic lateral sclerosis, APOE
Related Diseases	ALS, ALZHEIMER, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oligodendrocytes in Multiple System Atrophy

cell · 593 words

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Pathway Diagram

graph TD
    OLIGODENDROCYTES["OLIGODENDROCYTES"]
    OLIGODENDROCYTES -->|"produces"| myelin["myelin"]
    OLIGODENDROCYTES -->|"expressed in"| Prosaposin["Prosaposin"]
    OLIGODENDROCYTES -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    OLIGODENDROCYTES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    OLIGODENDROCYTES -->|"activates"| neuroinflammation["neuroinflammation"]
    OLIGODENDROCYTES -->|"activates"| neurodegeneration["neurodegeneration"]
    OLIGODENDROCYTES -->|"secretes"| IL6["IL6"]
    OLIGODENDROCYTES -->|"causes"| PARKIN["PARKIN"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON["PARKINSON"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON_S["PARKINSON'S"]
    HSPA1A["HSPA1A"] -->|"expressed in"| OLIGODENDROCYTES
    Microglia["Microglia"] -->|"interacts"| OLIGODENDROCYTES
    OxPC["OxPC"] -->|"causes"| OLIGODENDROCYTES
    BIN1["BIN1"] -->|"expressed in"| OLIGODENDROCYTES
    GPR37["GPR37"] -->|"expressed in"| OLIGODENDROCYTES
    DOPAMINERGIC_NEURONS["DOPAMINERGIC_NEURONS"] -->|"interacts"| OLIGODENDROCYTES
    OXPCS["OXPCS"] -->|"inhibits"| OLIGODENDROCYTES
    OxPCs["OxPCs"] -->|"causes"| OLIGODENDROCYTES
    AQP4["AQP4"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTE["ASTROCYTE"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTES["ASTROCYTES"] -->|"activates"| OLIGODENDROCYTES
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OLIGODENDROCYTES

Outgoing (264)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Neuroinflammation	associated_with	process	0.95
Neuroinflammation	causes	process	0.95
Metabolic Reallocation	involved_in	process	0.95
Neurodegeneration	associated_with	process	0.95
Alzheimer's Disease	involved_in	disease	0.95
Myelin	associated_with	process	0.95
Neurodegeneration	contributes_to	process	0.92
myelin	produces	protein	0.90
Parkinson's Disease	contributes_to	disease	0.90
TAU	interacts_with	protein	0.90
Tau Pathology	interacts_with	process	0.90
Alzheimer's Disease Pathogenesis	contributes_to	process	0.90
Amyloid Pathology	interacts_with	process	0.90
multiple sclerosis	associated_with	disease	0.90
Neuroinflammation	mediates	process	0.90
Neurodegeneration	mediates	process	0.90
Myelin Degeneration	contributes_to	process	0.90
Alzheimer'S Disease	contributes_to	disease	0.85
Immune Modulation	mediates	process	0.85
Dna Damage Response	expressed_in	pathway	0.85
Stress Response	associated_with	process	0.85
Disease Progression	contributes_to	process	0.85
Inflammation	modulates	process	0.85
Brain Ageing	associated_with	process	0.85
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.85
sphingolipid metabolism	active_in	pathway	0.85
Vascular Dementia	involved_in	disease	0.85
neurodegeneration	associated_with	disease	0.80
multiple sclerosis	activates	disease	0.80
MS lesions	expressed_in	process	0.80
multiple sclerosis	inhibits	disease	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Cellular Survival	mediates	process	0.80
NEUROINFLAMMATION	drives	process	0.80
neurodegeneration	drives	process	0.80
Prosaposin	expressed_in	protein	0.80
Oxidative Stress	involved_in	process	0.80
Synaptic Dysfunction	contributes_to	process	0.80
demyelination	implicated_in	process	0.80
neurons	interacts_with	cell_type	0.80
COHESIN COMPLEX	expressed_in	protein	0.75
unfolded protein response	active_in	pathway	0.75
Defense Mechanisms	mediates	process	0.75
Apoptosis	protects_against	process	0.75
neuroinflammation	activates	phenotype	0.72
neurodegeneration	activates	phenotype	0.72
NEURODEGENERATION	activates	phenotype	0.72
NEUROINFLAMMATION	activates	phenotype	0.72
NEURODEGENERATION	causes	phenotype	0.72

Incoming (743)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
NEURON	regulates	cell_type	0.95
NEURON	activates	cell_type	0.95
MICROGLIA	regulates	cell_type	0.95
lipid metabolism	active_in	pathway	0.90
Alzheimer's disease	affects	disease	0.90
SMS2	expressed_in	gene	0.90
FERROPTOSIS	affects	process	0.90
MOG	expressed_in	gene	0.90
neuroinflammation	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
aging	affects	disease	0.90
neurodegeneration	affects	disease	0.90
axon	found_in	organelle	0.90
multiple sclerosis	affects	disease	0.90
OxPC	mediates	compound	0.90
BDNF	promotes	gene	0.90
Oxidized Phosphatidylcholines	targets	compound	0.90
Oxidized Phosphatidylcholines	mediates	compound	0.90
Oligodendrocyte Precursor Cells	involved_in	cell_type	0.90
HSPA1A	expressed_in	gene	0.90
GPR37	expressed_in	gene	0.88
PIEZO1	regulates	protein	0.85
Microglia	interacts_with	cell_type	0.85
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
GBA1	expressed_in	gene	0.85
Astrocytes	interacts_with	cell_type	0.85
BIN1	expressed_in	gene	0.80
AQP4	expressed_in	gene	0.80
Parkinson's disease	affects	disease	0.80
Remyelinating Agents	targets	drug	0.80
OxPC	causes	chemical	0.80
BIN1	expressed_in	protein	0.80
SGMS1	implicated_in	gene	0.80
SGMS1	regulates	gene	0.80
SGMS1	associated_with	gene	0.80
complement cascade	active_in	pathway	0.80
NLRP3	activates	gene	0.80
NLRP3	expressed_in	gene	0.80
SMPD1	expressed_in	gene	0.80
Piezo1	regulates	gene	0.80
NLRP3	regulates	gene	0.80
MBP	expressed_in	gene	0.80
pyroptosis	active_in	pathway	0.80
RNA	expressed_in	gene	0.80
DNA Damage Response	upregulates	pathway	0.75
APOE4	associated_with	protein	0.75
AUTOPHAGY	expressed_in	process	0.75
frontotemporal dementia	affects	disease	0.70
C3	expressed_in	gene	0.70