concept

LYSOSOMAL ACIDIFICATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL ACIDIFICATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

1Hypotheses

2Analyses

5Outgoing

11Incoming

0Experiments

2Debates

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💡 Concept Info

Name	LYSOSOMAL ACIDIFICATION
Key Genes/Proteins	APP-ΒCTF

Pathway Diagram

graph TD
    LYSOSOMAL_ACIDIFICATION[LYSOSOMAL ACIDIFICATION]
    LYSOSOMAL_ACIDIFICATION -->|promotes| Hydrolase_Activity[Hydrolase Activity]
    LYSOSOMAL_ACIDIFICATION -->|involved_in| AUTOPHAGY[AUTOPHAGY]
    LYSOSOMAL_ACIDIFICATION -->|regulates| alpha_synuclein[alpha-synuclein]
    Palmitate[Palmitate] -->|inhibits| LYSOSOMAL_ACIDIFICATION
    AMPK[AMPK] -.protects against.-> LYSOSOMAL_ACIDIFICATION
    LAMP1[LAMP1] -->|promotes| LYSOSOMAL_ACIDIFICATION
    LAMP2[LAMP2] -->|promotes| LYSOSOMAL_ACIDIFICATION
    C19ORF12[C19ORF12] -->|regulates| LYSOSOMAL_ACIDIFICATION
    APP__CTF[APP-ΒCTF] -->|inhibits| LYSOSOMAL_ACIDIFICATION
    ATP6AP2[ATP6AP2] -->|participates in| LYSOSOMAL_ACIDIFICATION
    ATP6V1G1[ATP6V1G1] -->|regulates| LYSOSOMAL_ACIDIFICATION

Outgoing (5)

Target	Relation	Type	Str
lysosomal hydrolytic function	associated_with	process	0.90
Hydrolase Activity	promotes	process	0.85
AUTOPHAGY	involved_in	process	0.85
protein degradation	enables	process	0.70
alpha-synuclein	regulates	protein	0.70

Incoming (11)

Source	Relation	Type	Str
Palmitate	inhibits	compound	0.95
AMPK	protects_against	protein	0.95
LAMP1	associated_with	protein	0.90
LAMP2	associated_with	protein	0.90
ATP6V1A	encodes_subunit_of	gene	0.90
C19ORF12	regulates	gene	0.80
APP-ΒCTF	inhibits	protein	0.80
ATP6AP2	participates_in	gene	0.80
ATP6V1G1	regulates	gene	0.70
LAMP1	regulates	protein	0.70
TFEB	regulates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Restoration of V-ATPase function reverses lysosomal acidific	0.630	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do host cell factors influence the conformation and propagation properties o

neurodegeneration | 2026-04-08 | 0 hypotheses

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

How do host cell factors influence the conformation and propagation properties o

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning LYSOSOMAL ACIDIFICATION in their description or question text

No additional research found