protein 1,516 words KG: LAMP2PROTEIN
Contents

LAMP2 Protein

🔬 Protein Info
Gene SymbolLAMP2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight45 kDa
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
Ensembl IDENSG00000143106
GeneCardsLAMP2
Human Protein AtlasLAMP2
Associated DiseasesAls, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compoundsquercetin, rapamycin, RAPAMYCIN, statins
InteractionsACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
SciDEX HypothesesLAMP2A Liquid-Liquid Phase Separation Defects in D
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Pre
KG Connections1100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (10)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.59
Lysosomal Membrane Repair Enhancement
Score: 0.54
APOE-Dependent Autophagy Restoration
Score: 0.88
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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