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protein 2,292 words KG: LAMP2A
Contents

LAMP2A Protein — Lysosomal-Associated Membrane Protein 2A

🔬 Protein Info
Gene SymbolLAMP2A
Protein TypeProtein
Molecular Weight45 kDa
Amino Acids12 aa
Exons9
PathwaysAutophagy, Chaperone, Oxidative Stress, Proteostasis
UniProt IDSearch UniProt
GeneCardsLAMP2A
Human Protein AtlasLAMP2A
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compoundsrapamycin
InteractionsACAT1, AMPK, amyotrophic lateral sclerosis, AND, AR, ATG
KG Connections434 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.88Autophagosome Maturation Checkpoint Control
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64Quantum Coherence Disruption in Cellular Communication
Score: 0.63TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (8)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (4)

Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40Gene expression analysis of autophagy targets following treh
exploratory · proposed · Score: 0.85Trehalose-induced autophagy gene expression analysis
exploratory · proposed · Score: 0.85

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: associated_withACTB Gene
gene · KG edge: regulatesar
gene · KG edge: activates

Knowledge Graph (12 edges)

STIP1 associated_with LAMP2A
LGALS3 associated_with LAMP2A
HSPA8 associated_with LAMP2A
MCOLN1 associated_with LAMP2A
SQSTM1 associated_with LAMP2A
SOD1 associated_with LAMP2A
BCL2 associated_with LAMP2A
CTSB associated_with LAMP2A
TPP1 associated_with LAMP2A
GLA associated_with LAMP2A

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