gene 989 words KG: LAMP2
Contents

LAMP2 Gene

🧬 Gene Info
Gene SymbolLAMP2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight45 kDa
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
Ensembl IDENSG00000143106
GeneCardsLAMP2
Human Protein AtlasLAMP2
Associated DiseasesAls, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compoundsquercetin, rapamycin, RAPAMYCIN, statins
InteractionsACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
KG Connections1105 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.57
Lysosomal Membrane Repair Enhancement
Score: 0.54
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
CYP46A1 Overexpression Gene Therapy
Score: 0.92

Related Analyses (14)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (1)

Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACTB Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

VAMP8 associated_with LAMP2
LAMP2 associated_with GBM
LAMP2 associated_with LC3
LAMP2 associated_with EPG5
LAMP2 associated_with STX17
LAMP2 associated_with SQSTM1
LAMP2 associated_with SNAP29
LAMP2 associated_with SDC1
LAMP2 associated_with TGM2
GABARAP associated_with LAMP2

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