protein 833 words KG: LAMP2
Contents

LAMP2 Protein

🔬 Protein Info
Gene SymbolLAMP2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight45 kDa
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
Ensembl IDENSG00000143106
GeneCardsLAMP2
Human Protein AtlasLAMP2
Associated DiseasesAls, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compoundsquercetin, rapamycin, RAPAMYCIN, statins
InteractionsACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
SciDEX HypothesesLAMP2A Liquid-Liquid Phase Separation Defects in D
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Pre
KG Connections1100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (42)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.59
Lysosomal Membrane Repair Enhancement
Score: 0.54
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
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Related Analyses (18)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACTB Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

VAMP8 associated_with LAMP2
LAMP2 associated_with GBM
LAMP2 associated_with LC3
LAMP2 associated_with EPG5
LAMP2 associated_with STX17
LAMP2 associated_with SQSTM1
LAMP2 associated_with SNAP29
LAMP2 associated_with SDC1
LAMP2 associated_with TGM2
GABARAP associated_with LAMP2

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