gene

EPG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

0Debates

Summary

Page for EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

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🧬 Gene Info

Gene Symbol	EPG5
Full Name	Ectopic P-Granules 5 Autophagy Tutor
Aliases	Page for EPG5 Gene
Chromosome	18q12.3
Function	Autophagosome maturation: EPG5 promotes the maturation of autophagosomes by facilitating their fusion with lysosomes
Primary Expression	Cerebral cortex, Brain stem, Spinal cord, Testis, Heart
Molecular Weight	282 kDa
Amino Acids	2573 aa
Exons	36
Pathways	Autophagy
UniProt ID	Q9H7D3
NCBI Gene ID	2058
Ensembl ID	ENSG00000151692
OMIM	614921
GeneCards	EPG5
Human Protein Atlas	EPG5
Associated Diseases	Glioblastoma, Tumor
Interactions	GLIOBLASTOMA, LAMP2, MAP1LC3, SNARE, SQSTM1, TGM2
KG Connections	78 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPG5 — AlphaFold Q9H7D3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

gene · 3160 words

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EPG5 Protein

protein · 652 words

→

Pathway Diagram

graph TD
    EPG5["EPG5"]
    Autophagosome_Lysosome_Fusion(["Autophagosome-Lysosome Fusion"])
    EPG5 -->|"mediates"| Autophagosome_Lysosome_Fusion
    Glioblastoma{"Glioblastoma"}
    EPG5 -->|"associated with"| Glioblastoma
    Tumor{"Tumor"}
    EPG5 -->|"associated with"| Tumor
    EPG5 -->|"regulates"| Tumor
    STX17["STX17"]
    EPG5 -->|"associated with"| STX17
    SQSTM1["SQSTM1"]
    EPG5 -->|"associated with"| SQSTM1
    SNAP29["SNAP29"]
    EPG5 -->|"associated with"| SNAP29
    SDC1["SDC1"]
    EPG5 -->|"associated with"| SDC1
    TGM2["TGM2"]
    EPG5 -->|"associated with"| TGM2
    Autophagy(["Autophagy"])
    EPG5 -->|"associated with"| Autophagy
    LC3["LC3"]
    EPG5 -->|"associated with"| LC3
    GBM["GBM"]
    EPG5 -->|"associated with"| GBM
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| EPG5
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| EPG5
    GBM -->|"associated with"| EPG5
    LC3 -->|"associated with"| EPG5
    SQSTM1 -->|"associated with"| EPG5
    SDC1 -->|"associated with"| EPG5
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| EPG5
    P62["P62"]
    P62 -->|"associated with"| EPG5
    SNAP29 -->|"associated with"| EPG5
    STX17 -->|"associated with"| EPG5
    TGM2 -->|"associated with"| EPG5
    GFP["GFP"]
    GFP -->|"associated with"| EPG5
    style EPG5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.90
Glioblastoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Tumor	regulates	disease	0.65
GFP	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
SDC1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
Fus	regulates	protein	0.60
AUTOPHAGY	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
glioblastoma	regulates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
SQSTM1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
GBM	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
P62	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
SDC1	mediates	entity	0.60
TGM2	mediates	entity	0.60
LC3	interacts_with	entity	0.60
SDC1	interacts_with	entity	0.60
SNAP29	interacts_with	entity	0.60
STX17	interacts_with	entity	0.60
TGM2	interacts_with	entity	0.60
VAMP8	interacts_with	entity	0.60
GBM	therapeutic_target	entity	0.60
SDC1	therapeutic_target	entity	0.60
TGM2	therapeutic_target	entity	0.60
GBM	regulates	entity	0.60
LAMP2	regulates	entity	0.60
LC3	regulates	entity	0.60
P62	regulates	entity	0.60
SDC1	regulates	entity	0.60
SNAP29	regulates	entity	0.60
SQSTM1	regulates	entity	0.60
STX17	regulates	entity	0.60
TGM2	regulates	entity	0.60
VAMP8	regulates	entity	0.60
AND	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Actin	associated_with	protein	0.60
Autophagy	associated_with	pathway	0.60

Incoming (21)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SDC1	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
STX17	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
GBM	regulates	gene	0.60
TGM2	regulates	gene	0.60
SDC1	regulates	gene	0.60
TGM2	interacts_with	protein	0.60
MAP1LC3	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
LC3	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AND	regulates	gene	0.60
Autophagy	interacts_with	process	0.50
autophagy	co_mentioned	pathway	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPG5 in their description or question text

No additional research found