gene

IL4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

205Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IL4 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, therapeutic target, activates. Associated with ALS, Als, Alzheimer. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL4
Full Name	Interleukin 4
Chromosome	5q31.3
Function	The IL4 gene encodes a protein involved in cellular signaling that is critical for development, tissue homeostasis, and immune regulation.
Primary Expression	various brain regions including cortex, hippocampus, and basal ganglia
Molecular Weight	15 kDa
Amino Acids	129 aa
Pathways	Autophagy
UniProt ID	[P05112](https://www.uniprot.org/uniprot/P05112)
Ensembl ID	ENSG00000100994
GeneCards	IL4
Human Protein Atlas	IL4
Associated Diseases	Ischemia
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, Aβ, BMAL1, CCL2
KG Connections	205 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL4 Gene

gene · 801 words

→

IL4 Protein

protein · 876 words

→

Pathway Diagram

flowchart TD
    IL4["IL4"] -.->|"inhibits"| CLDN1["CLDN1"]
    IL4["IL4"] -.->|"inhibits"| CLDN4["CLDN4"]
    IL4["IL4"] -.->|"inhibits"| OCLN["OCLN"]
    IL4["IL4"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    IL4["IL4"] -->|"biomarker for"| Als["Als"]
    IL4["IL4"] -->|"biomarker for"| Inflammation["Inflammation"]
    IL4["IL4"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    IL4["IL4"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    IL4["IL4"] -->|"associated with"| Ischemia["Ischemia"]
    IL4["IL4"] -.->|"inhibits"| Ms["Ms"]
    IL4["IL4"] -->|"biomarker for"| ALS["ALS"]
    IL4["IL4"] -->|"activates"| FGF2["FGF2"]
    style IL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CLDN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CLDN4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style OCLN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style FGF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (114)

Target	Relation	Type	Str
Microglia	activates	cell_type	0.95
Anti-Inflammatory Reactivity	promotes	process	0.90
ARRB2	regulates	gene	0.85
HMGB1	inhibits	protein	0.85
ARRB1	regulates	gene	0.85
Amyloid Pathology	biomarker_for	process	0.80
motor recovery	promotes	phenotype	0.80
Amyloid Pathology	upregulates	process	0.80
OCLN	inhibits	gene	0.72
CLDN4	inhibits	gene	0.72
CLDN1	inhibits	gene	0.72
ALS	biomarker_for	disease	0.65
Als	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	biomarker_for	disease	0.65
Ischemia	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Sepsis	activates	disease	0.65
Infection	activates	disease	0.65
Ms	inhibits	disease	0.65
Cardiac	activates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
GUT-BRAIN AXIS	regulates	gene	0.60
AND	associated_with	gene	0.60
Cerebrovascular	biomarker_for	pathway	0.60
CYTOKINES	therapeutic_target	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
Circadian Rhythm	activates	pathway	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
oxidative stress response	participates_in	pathway	0.60
MAP1LC3	regulates	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
Alzheimer's disease	regulates	disease	0.60
TLR	regulates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
autophagy pathway	participates_in	pathway	0.60
Ras	therapeutic_target	protein	0.60
App	biomarker_for	protein	0.60
Fgf	activates	protein	0.60
Immune Response	activates	pathway	0.60

Incoming (91)

Source	Relation	Type	Str
Mbdnf@Αitgev	upregulates	compound	0.90
CYTOKINES	regulates	gene	0.60
IL-4	associated_with	gene	0.60
APOE	biomarker_for	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
GSTP1	therapeutic_target	gene	0.60
SREBF1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CAT	therapeutic_target	gene	0.60
GFAP	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
FGF2	upregulates	entity	0.60
C5	associated_with	gene	0.60
IL18	associated_with	gene	0.60
IL10	regulates	gene	0.60
IL13	regulates	gene	0.60
AKT1	regulates	gene	0.60
CXCL8	regulates	gene	0.60
BDNF	causes	gene	0.60
BDNF	protects_against	gene	0.60
TAU	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
IL12	associated_with	gene	0.60
CCL2	regulates	gene	0.60
IL9	activates	gene	0.60
VEGFA	biomarker_for	gene	0.60
SQSTM1	biomarker_for	gene	0.60
CHIT1	biomarker_for	gene	0.60
FGF2	activates	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
MDH1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
PDGFRB	biomarker_for	gene	0.60
FOS	contributes_to	gene	0.60
IL6	associated_with	gene	0.60
MAPK14	contributes_to	gene	0.60
REST	activates	gene	0.60
CD68	activates	gene	0.60
TNF	activates	gene	0.60
NR1D1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL4 in their description or question text

No additional research found