concept

QUERCETIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about QUERCETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

373Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	QUERCETIN
Key Genes/Proteins	ABCA1, ACHE, AKT, AKT1, AMPK, AMYLOID
Related Diseases	AGING, ALZHEIMER, Alzheimer Disease, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    QUERCETIN["QUERCETIN"]
    QUERCETIN -.protects against.-> Diabetic_Nephropathy["Diabetic Nephropathy"]
    QUERCETIN -->|"inhibits"| Renal_Tubular_Epithelial_Cell_["Renal Tubular Epithelial Cell Apoptosis"]
    QUERCETIN -->|"inhibits"| Neuronal_Pyroptosis["Neuronal Pyroptosis"]
    QUERCETIN -->|"inhibits"| PI3K_AKT["PI3K/AKT"]
    QUERCETIN -->|"treats"| Cerebral_Ischemia_Reperfusion_["Cerebral Ischemia/Reperfusion Injury"]
    QUERCETIN -->|"regulates"| PI3K_Akt_NF__B_Signaling_Pathw["PI3K/Akt/NF-kappaB Signaling Pathway"]
    QUERCETIN -.protects against.-> HK_2_Cells["HK-2 Cells"]
    QUERCETIN -->|"modulates"| Microglial_M1_M2_Polarization["Microglial M1/M2 Polarization"]
    MICROGLIA["MICROGLIA"] -->|"inhibits"| QUERCETIN
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] -->|"target for"| QUERCETIN
    DASATINIB["DASATINIB"] -->|"target for"| QUERCETIN
    CANCER["CANCER"] -->|"regulates"| QUERCETIN
    MACROPHAGES["MACROPHAGES"] -->|"activates"| QUERCETIN
    ISCHEMIA["ISCHEMIA"] -->|"activates"| QUERCETIN

Outgoing (234)

Target	Relation	Type	Str
TNF-α Induced Apoptosis	inhibits	process	0.95
Renal Tubular Epithelial Cell Apoptosis	inhibits	process	0.95
Diabetic Nephropathy	protects_against	disease	0.95
Neuronal Pyroptosis	inhibits	process	0.95
Nrf2/Ho1 Pathway	activates	pathway	0.95
Microglia/Macrophages M2 Polarization	associated_with	process	0.95
Cellular Senescence	inhibits	process	0.95
Senescent Human Endothelial Cells	treats	cell_type	0.95
ROS	modulates	process	0.95
Microglia M1/M2 Polarization	modulates	process	0.95
Inflammation	inhibits	process	0.95
PI3K/AKT	inhibits	pathway	0.93
Cognitive Deficits	treats	phenotype	0.92
NF-κB	downregulates	pathway	0.92
AP-1	downregulates	pathway	0.92
ferroptosis	inhibits	process	0.90
ALZHEIMER'S DISEASE	treats	disease	0.90
NF-κB	inhibits	protein	0.90
NFE2L2	activates	gene	0.90
ANTIOXIDANT DEFENSE	activates	mechanism	0.90
Cerebral Ischemia/Reperfusion Injury	treats	disease	0.90
PI3K/Akt/NF-κB Signaling Pathway	regulates	pathway	0.90
HK-2 Cells	protects_against	cell_type	0.90
Microglial M1/M2 Polarization	modulates	process	0.90
Senescent Cells	targets	cell_type	0.90
Alzheimer'S Disease	treats	disease	0.90
Neuroinflammation	inhibits	process	0.90
Neurodegeneration	protects_against	process	0.85
Type 2 Diabetes Mellitus	contributes_to	disease	0.85
Infarct Volume	associated_with	biomarker	0.85
AMPK	activates	protein	0.85
Neuroinflammation	protects_against	process	0.85
Neurological Deficits	associated_with	disease	0.85
INFLAMMATION	inhibits	process	0.85
iron homeostasis	regulates	process	0.85
DEMENTIA	treats	disease	0.85
Senescent cell survival	suppresses	process	0.80
JNK	binds_to	protein	0.80
Anti-inflammatory Activity	involved_in	mechanism	0.80
Anti-apoptotic Activity	involved_in	mechanism	0.80
Antioxidant Activity	involved_in	mechanism	0.80
Cancer Signaling Pathways	modulates	pathway	0.80
PI3K/Akt/NF-κB	inhibits	pathway	0.80
senescent cells	associated_with	cell_type	0.80
IL-6	inhibits	protein	0.78
AMPK/SIRT1 Signaling Pathway	activates	pathway	0.75
MYC	binds_to	gene	0.75
senolytic_therapy	associated_with	drug	0.75
senescence	modulates	pathway	0.75
kidney disease	treats	disease	0.75

Incoming (139)

Source	Relation	Type	Str
32093448	is	paper	0.90
32093448	decreases	paper	0.90
APP	activates	gene	0.70
DIABETES	causes	disease	0.65
MICROGLIA	protects_against	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
MAPK	targets	gene	0.65
MACROPHAGE	protects_against	cell_type	0.65
ALZHEIMER	treats	disease	0.65
DIABETES	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
32093448	may be beneficial in	paper	0.60
32093448	prevents	paper	0.60
SYNAPTIC LOSS	associated_with	phenotype	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
COGNITIVE DECLINE	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
SENESCENCE	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
CGAS-STING PATHWAY	associated_with	pathway	0.50
STING PATHWAY	associated_with	pathway	0.50
LIPID PEROXIDATION	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
Pi3K/Akt	activates	pathway	0.50
NF-κB	activates	concept	0.50
Pi3K	activates	pathway	0.50
microglia	activates	cell_type	0.50
mTOR	inhibits	entity	0.50
microglia	inhibits	cell_type	0.50
DIABETES MELLITUS	associated_with	concept	0.50
Type 2 Diabetes	associated_with	disease	0.50
Alzheimer'S Disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
EGFR	associated_with	gene	0.50
AKT1	associated_with	gene	0.50
VEGFA	associated_with	protein	0.50
MAPK	associated_with	gene	0.50
Neuroprotection	interacts_with	process	0.50
ALZHEIMER	associated_with	gene	0.50
DIABETES	associated_with	disease	0.50
Alzheimer Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
cancer	regulates	disease	0.50
cancer	associated_with	disease	0.50
Neuroinflammation	inhibits	process	0.50
AMYLOID	inhibits	gene	0.50
EPILEPSY	targets	gene	0.50
FLAVONOIDS	decreases_risk	concept	0.50
MICROGLIA	inhibits	cell_type	0.50