gene

CTSS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

44Outgoing

16Incoming

0Experiments

0Debates

Summary

CTSS is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Alzheimer, Inflammation. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSS
Full Name	Cathepsin S
Chromosome	1q21.3
Protein Type	Protease
Function	encodes a lysosomal cysteine protease that has emerged as a critical player in both immune function and neurodegenerative disease pathogenesis.
Primary Expression	Microglia, Macrophages, Dendritic cells
Molecular Weight	37 kDa
Amino Acids	331 aa
UniProt ID	P07237
NCBI Gene ID	1520
Ensembl ID	ENSG00000163131
OMIM	600565
GeneCards	CTSS
Human Protein Atlas	CTSS
Associated Diseases	Aging
Interactions	AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, APP/PS1
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSS — AlphaFold P07237 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CTSS — Cathepsin S

gene · 1679 words

→

Cathepsin S - CTSS Protein

protein · 772 words

→

Pathway Diagram

graph TD
    CTSS["CTSS"]
    Inflammation{"Inflammation"}
    CTSS -->|"activates"| Inflammation
    Ms{"Ms"}
    CTSS -->|"inhibits"| Ms
    Alzheimer{"Alzheimer"}
    CTSS -->|"activates"| Alzheimer
    Aging{"Aging"}
    CTSS -->|"regulates"| Aging
    Neuroinflammation{"Neuroinflammation"}
    CTSS -->|"regulates"| Neuroinflammation
    CTSS -->|"regulates"| Inflammation
    AHR["AHR"]
    CTSS -->|"inhibits"| AHR
    CTSD["CTSD"]
    CTSS -->|"inhibits"| CTSD
    LAMP2["LAMP2"]
    CTSS -->|"inhibits"| LAMP2
    Autophagy(["Autophagy"])
    CTSS -->|"inhibits"| Autophagy
    CYTOKINES["CYTOKINES"]
    CTSS -->|"inhibits"| CYTOKINES
    INFLAMMATION["INFLAMMATION"]
    CTSS -->|"activates"| INFLAMMATION
    AGING["AGING"]
    AGING -->|"regulates"| CTSS
    CTSB["CTSB"]
    CTSB -->|"activates"| CTSS
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    MICROGLIA_ACTIVATION -->|"activates"| CTSS
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| CTSS
    CTSL["CTSL"]
    CTSL -->|"activates"| CTSS
    style CTSS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	implicated_in	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Alzheimer	activates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
CTSB	activates	gene	0.60
AKT	biomarker_for	gene	0.60
MTOR	biomarker_for	gene	0.60
CX3CL1	regulates	protein	0.60
JAK2	upstream_of	protein	0.60
NPTX1	inhibits	gene	0.60
SERPINA3	inhibits	gene	0.60
NRXN2	inhibits	gene	0.60
VGF	inhibits	gene	0.60
CTSD	activates	gene	0.60
Autophagy	inhibits	pathway	0.60
CYTOKINES	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
APP/PS1	inhibits	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AGING	implicated_in	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Tgf-Β	biomarker_for	pathway	0.60
Mtor	biomarker_for	pathway	0.60
Akt	biomarker_for	pathway	0.60
SYNAPSE	inhibits	gene	0.60
Pi3K	biomarker_for	pathway	0.60
AHR	inhibits	gene	0.60
CTSD	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
JAK2	activates	gene	0.60
STAT3	activates	gene	0.60
APP	inhibits	gene	0.60
CX3CL1	activates	gene	0.60
CX3CR1	activates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
STAT3	activates	gene	0.60
JAK2	activates	gene	0.60
PI3K	biomarker_for	gene	0.60
HSPA1A	regulates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
AGING	regulates	gene	0.60
AND	regulates	gene	0.60
SLC3A2	regulates	gene	0.60
CANCER	biomarker_for	gene	0.60
AMYLOID	inhibits	gene	0.60
CTSB	activates	gene	0.60
CTSL	activates	gene	0.60
CST3	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTSS in their description or question text

No additional research found