concept

CHAPERONE-MEDIATED AUTOPHAGY

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CHAPERONE-MEDIATED AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CHAPERONE-MEDIATED AUTOPHAGY
Key Genes/Proteins	AMPK, BECN1, CALCOCO2, CREB, CREBBP
Related Diseases	disease
Related Pathways	Chaperone

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Chaperone-Mediated Autophagy in Neurodegeneration

mechanism · 3671 words

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Pathway Diagram

graph TD
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"inhibits"| GPX4["GPX4"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"interacts"| Macroautophagy["Macroautophagy"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"regulates"| __synuclein_clearance["alpha-synuclein clearance"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| UBIQUITIN["UBIQUITIN"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| LYSOSOME["LYSOSOME"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| SQSTM1["SQSTM1"]
    LAMP2A["LAMP2A"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    LAMP2["LAMP2"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    BECN1["BECN1"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY

Outgoing (37)

Target	Relation	Type	Str
PLIN2	degrades	protein	0.95
SNCA	mediates	protein	0.90
Aggregated/Misfolded Proteins	degrades	phenotype	0.89
Substrate Recognition	associated_with	mechanism	0.85
α-synuclein	targets	protein	0.85
protein aggregation	suppresses	phenotype	0.85
ferroptosis	associated_with	pathway	0.80
GPX4	inhibits	gene	0.80
Macroautophagy	interacts_with	process	0.75
α-synuclein clearance	regulates	process	0.70
RAPAMYCIN	activates	drug	0.35
SQSTM1	activates	gene	0.35
SIRT1	activates	gene	0.35
GAPDH	activates	gene	0.35
MTOR	activates	gene	0.35
TP53	activates	gene	0.35
TFEB	activates	gene	0.35
ULK1	activates	gene	0.35
OPTN	activates	gene	0.35
CREB	activates	gene	0.35
P62	activates	gene	0.35
LC3	activates	gene	0.35
P53	activates	gene	0.35
MITOPHAGY	regulates	process	0.35
P62	regulates	gene	0.35
ROS	regulates	protein	0.35
FERROPTOSIS	activates	process	0.35
NEURON	activates	cell_type	0.35
GPX4	activates	gene	0.35
UBIQUITIN-PROTEASOME	regulates	process	0.35
DOPAMINERGIC NEURONS	interacts_with	cell_type	0.35
NEURON	interacts_with	cell_type	0.35
LAMP2	interacts_with	gene	0.35
DOPAMINERGIC NEURONS	regulates	cell_type	0.35
UBIQUITIN	activates	gene	0.35
PARKINSON'S DISEASE	activates	disease	0.35
RB1	activates	gene	0.35

Incoming (82)

Source	Relation	Type	Str
LAMP2A	involved_in	protein	0.95
African Swine Fever Virus	associated_with	disease	0.95
LRRK2	modulates	gene	0.90
LRRK2	regulates	protein	0.85
HSPA8	involved_in	protein	0.85
GBA1	involved_in	gene	0.85
LAMP2A	regulates	protein	0.70
LAMP2	regulates	protein	0.70
LAMP2A	activates	protein	0.70
GBA1	inhibits	gene	0.70
AUTOPHAGY	regulates	process	0.65
PGC-1Α	activates	protein	0.50
FBXW7	activates	concept	0.50
PGC-1Α	regulates	protein	0.50
UBIQUITIN	regulates	protein	0.50
Ubiquitin-Proteasome	regulates	pathway	0.50
FBXW7	regulates	concept	0.50
Proteostasis	regulates	process	0.50
ULK1	activates	gene	0.50
OPTN	activates	gene	0.50
NDP52	activates	gene	0.50
FIP200	activates	gene	0.50
SQSTM1	activates	gene	0.50
SNAP29	activates	gene	0.50
mTOR	activates	entity	0.50
WIPI2	activates	gene	0.50
PIK3C3	activates	gene	0.50
KAT8	activates	gene	0.50
GAPDH	activates	gene	0.50
TP53	activates	gene	0.50
SIRT1	activates	gene	0.50
RUBCN	activates	gene	0.50
HDAC6	activates	gene	0.50
CREBBP	activates	gene	0.50
EP300	activates	gene	0.50
LAMP2A	activates	gene	0.50
RB1CC1	activates	gene	0.50
KAT2A	activates	gene	0.50
KAT5	activates	gene	0.50
STX17	activates	gene	0.50
VAMP8	activates	gene	0.50
HSPA8	activates	gene	0.50
CALCOCO2	activates	gene	0.50
NBR1	activates	gene	0.50
CREB	activates	protein	0.50
SNARE	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
RUBICON	activates	protein	0.50
HSP70	activates	protein	0.50
UBIQUITIN	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHAPERONE-MEDIATED AUTOPHAGY in their description or question text

No additional research found