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gene 1,229 words KG: HSPA8
Contents

HSPA8 Gene

🧬 Gene Info
Gene SymbolHSPA8
Full NameHeat Shock Protein Family A (Hsp70) Member 8
Chromosome9q33.3
FunctionHsc70 participates in multiple cellular processes:
Molecular Weight71 kDa
Amino Acids646 aa
PathwaysAutophagy
UniProt ID[P11142](https://www.uniprot.org/uniprot/P11142)
Ensembl IDENSG00000143371
GeneCardsHSPA8
Human Protein AtlasHSPA8
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Atherosclerosis, Cancer
Known Drugs/Compoundsrapamycin
InteractionsACAT1, ALPHA-SYNUCLEIN, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections495 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Autophagosome Maturation Checkpoint Control
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Glycine-Rich Domain Competitive Inhibition
Score: 0.64Quantum Coherence Disruption in Cellular Communication
Score: 0.63VCP-Mediated Autophagy Enhancement
Score: 0.59HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (9)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activatesAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: associated_withAKT1 Gene
gene · KG edge: therapeutic_targetar
gene · KG edge: activates

Knowledge Graph (12 edges)

STIP1 associated_with HSPA8
LGALS3 associated_with HSPA8
HSPA8 associated_with MCOLN1
HSPA8 associated_with SQSTM1
HSPA8 associated_with SOD1
HSPA8 associated_with BCL2
HSPA8 associated_with CTSB
HSPA8 associated_with TPP1
HSPA8 associated_with GLA
HSPA8 activates CALCINEURIN

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